Caveolin-1 mediates tissue plasminogen activator-induced MMP-9 up-regulation in cultured brain microvascular endothelial cells

Journal of Neurochemistry

Volumn 132, Issue 6, 2015, Pages 724-730

  Jin, Xinchun ^a   Sun, Yanyun ^a   Xu, Ji ^b   Liu, Wenlan ^b  

^a THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SHENZHEN UNIVERSITY   (China)

Author keywords

caveolin 1; matrix metalloproteinase; stroke; tight junction proteins; tissue plasminogen activator

Indexed keywords

ALTEPLASE; CAVEOLIN 1; GELATINASE B; MESSENGER RNA; SMALL INTERFERING RNA; MMP9 PROTEIN, MOUSE; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL CELL; ARTICLE; BRAIN CAPILLARY ENDOTHELIAL CELL; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME INDUCTION; ENZYME RELEASE; GENE SILENCING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; UPREGULATION; ANIMAL; BIOSYNTHESIS; BRAIN; DRUG EFFECTS; ENDOTHELIUM CELL; METABOLISM; MICROVASCULATURE; PHYSIOLOGY; VASCULARIZATION;

ANIMALS; BRAIN; CAVEOLIN 1; CELLS, CULTURED; ENDOTHELIAL CELLS; MATRIX METALLOPROTEINASE 9; MICE; MICROVESSELS; TISSUE PLASMINOGEN ACTIVATOR; UP-REGULATION;

EID: 84924532548     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.13065     Document Type: Article

References (36)

1. Alberts M. J., (1998) tPA in acute ischemic stroke: United States experience and issues for the future. Neurology 51, S53-S55.
2. Arai K., Lee S. R., and, Lo E. H., (2003) Essential role for ERK mitogen-activated protein kinase in matrix metalloproteinase-9 regulation in rat cortical astrocytes. Glia 43, 254-264.
3. Castellanos M., Leira R., Serena J., Pumar J. M., Lizasoain I., Castillo J., and, Davalos A., (2003) Plasma metalloproteinase-9 concentration predicts hemorrhagic transformation in acute ischemic stroke. Stroke 34, 40-46.
4. Castellanos M., Leira R., Serena J., Blanco M., Pedraza S., Castillo J., and, Davalos A., (2004) Plasma cellular-fibronectin concentration predicts hemorrhagic transformation after thrombolytic therapy in acute ischemic stroke. Stroke 35, 1671-1676.
5. Cheng T., Petraglia A. L., Li Z., et al,. (2006) Activated protein C inhibits tissue plasminogen activator-induced brain hemorrhage. Nat. Med. 12, 1278-1285.
6. Chow A. K., Cena J., El-Yazbi A. F., Crawford B. D., Holt A., Cho W. J., Daniel E. E., and, Schulz R., (2007) Caveolin-1 inhibits matrix metalloproteinase-2 activity in the heart. J. Mol. Cell. Cardiol. 42, 896-901.
7. Foley L. M., Hitchens T. K., Barbe B., Zhang F., Ho C., Rao G. R., and, Nemoto E. M., (2010) Quantitative temporal profiles of penumbra and infarction during permanent middle cerebral artery occlusion in rats. Transl. Stroke Res. 1, 220-229.
8. Gonzalez M. I., Krizman-Genda E., and, Robinson M. B., (2007) Caveolin-1 regulates the delivery and endocytosis of the glutamate transporter, excitatory amino acid carrier 1. J. Biol. Chem. 282, 29855-29865.
9. Gu Y., Zheng G., Xu M., et al,. (2011) Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury. J. Neurochem. 120, 147-156.
10. Hamann G. F., Okada Y., and, del Zoppo G. J., (1996) Hemorrhagic transformation and microvascular integrity during focal cerebral ischemia/reperfusion. J. Cereb. Blood Flow Metab. 16, 1373-1378.
11. Huang W., Andras I. E., Rha G. B., Hennig B., and, Toborek M., (2011) PPARalpha and PPARgamma protect against HIV-1-induced MMP-9 overexpression via caveolae-associated ERK and Akt signaling. FASEB J. 25, 3979-3988.
12. Jasmin J. F., Malhotra S., Singh Dhallu M., Mercier I., Rosenbaum D. M., and, Lisanti M. P., (2007) Caveolin-1 deficiency increases cerebral ischemic injury. Circ. Res. 100, 721-729.
13. Lapchak P. A., Chapman D. F., and, Zivin J. A., (2000) Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke. Stroke 31, 3034-3040.
14. Lisanti M. P., Scherer P. E., Tang Z., and, Sargiacomo M., (1994) Caveolae, caveolin and caveolin-rich membrane domains: a signalling hypothesis. Trends Cell Biol. 4, 231-235.
15. Liu W., Furuichi T., Miyake M., Rosenberg G. A., and, Liu K. J., (2007) Differential expression of tissue inhibitor of metalloproteinases-3 in cultured astrocytes and neurons regulates the activation of matrix metalloproteinase-2. J. Neurosci. Res. 85, 829-836.
16. Liu W., Hendren J., Qin X. J., and, Liu K. J., (2009) Normobaric hyperoxia reduces the neurovascular complications associated with delayed tissue plasminogen activator treatment in a rat model of focal cerebral ischemia. Stroke 40, 2526-2531.
17. Liu J., Jin X., Liu K. J., and, Liu W., (2012) Matrix metalloproteinase-2-mediated occludin degradation and caveolin-1-mediated claudin-5 redistribution contribute to blood-brain barrier damage in early ischemic stroke stage. J. Neurosci. 32, 3044-3057.
18. Madaro L., Antonangeli F., Favia A., et al,. (2013) Knock down of caveolin-1 affects morphological and functional hallmarks of human endothelial cells. J. Cell. Biochem. 114, 1843-1851.
19. Montaner J., Molina C. A., Monasterio J., Abilleira S., Arenillas J. F., Ribo M., Quintana M., and, Alvarez-Sabin J., (2003) Matrix metalloproteinase-9 pretreatment level predicts intracranial hemorrhagic complications after thrombolysis in human stroke. Circulation 107, 598-603.
20. Nag S., Venugopalan R., and, Stewart D. J., (2007) Increased caveolin-1 expression precedes decreased expression of occludin and claudin-5 during blood-brain barrier breakdown. Acta Neuropathol. 114, 459-469.
21. Okamoto T., Schlegel A., Scherer P. E., and, Lisanti M. P., (1998) Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J. Biol. Chem. 273, 5419-5422.
22. Park H., Go Y. M., Darji R., Choi J. W., Lisanti M. P., Maland M. C., and, Jo H., (2000) Caveolin-1 regulates shear stress-dependent activation of extracellular signal-regulated kinase. Am. J. Physiol. Heart Circ. Physiol. 278, H1285-H1293.
23. Pfefferkorn T., and, Rosenberg G. A., (2003) Closure of the blood-brain barrier by matrix metalloproteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfusion. Stroke 34, 2025-2030.
24. Rosell A., and, Lo E. H., (2008) Multiphasic roles for matrix metalloproteinases after stroke. Curr. Opin. Pharmacol. 8, 82-89.
25. Rosenberg G. A., and, Mun-Bryce S., (2004) Matrix metalloproteinases in neuroinflammation and cerebral ischemia. Ernst Schering Res. Found. Workshop, 47, 1-16.
26. Shen J., Ma S., Chan P., Lee W., Fung P. C., Cheung R. T., Tong Y., and, Liu K. J., (2006) Nitric oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion injury. J. Neurochem. 96, 1078-1089.
27. Simard J. M., Kent T. A., Chen M., Tarasov K. V., and, Gerzanich V., (2007) Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications. Lancet Neurol. 6, 258-268.
28. Smart E. J., Graf G. A., McNiven M. A., Sessa W. C., Engelman J. A., Scherer P. E., Okamoto T., and, Lisanti M. P., (1999) Caveolins, liquid-ordered domains, and signal transduction. Mol. Cell. Biol. 19, 7289-7304.
29. Tsuji K., Aoki T., Tejima E., et al,. (2005) Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Stroke 36, 1954-1959.
30. Wang X., Lee S. R., Arai K., Lee S. R., Tsuji K., Rebeck G. W., and, Lo E. H., (2003) Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat. Med. 9, 1313-1317.
31. Wang S., Lee S. R., Guo S. Z., Kim W. J., Montaner J., Wang X., and, Lo E. H., (2006) Reduction of tissue plasminogen activator-induced matrix metalloproteinase-9 by simvastatin in astrocytes. Stroke 37, 1910-1912.
32. Wang H., Wang A. X., Liu Z., Chai W., and, Barrett E. J., (2009) The trafficking/interaction of eNOS and caveolin-1 induced by insulin modulates endothelial nitric oxide production. Mol. Endocrinol. 23, 1613-1623.
33. Williams T. M., and, Lisanti M. P., (2004) The Caveolin genes: from cell biology to medicine. Ann. Med. 36, 584-595.
34. Williams T. M., Medina F., Badano I., et al,. (2004) Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. J. Biol. Chem. 279, 51630-51646.
35. Yepes M., Sandkvist M., Moore E. G., Bugge T. H., Strickland D. K., and, Lawrence D. A., (2003) Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J. Clin. Invest. 112, 1533-1540.
36. del Zoppo G. J., von Kummer R., and, Hamann G. F., (1998) Ischaemic damage of brain microvessels: inherent risks for thrombolytic treatment in stroke. J. Neurol. Neurosurg. Psychiatry 65, 1-9.