Composite scaffolds of nano-hydroxyapatite and silk fibroin enhance mesenchymal stem cell-based bone regeneration via the interleukin 1 alpha autocrine/paracrine signaling loop

Biomaterials

Volumn 49, Issue , 2015, Pages 103-112

  Liu, Hua ^b,c   Xu, Guo Wei ^b,c   Wang, Ya Fei ^b,c   Zhao, Hong Shi ^b,c   Xiong, Si ^b,c   Wu, Yan ^b,c   Heng, Boon Chin ^d   An, Cheng Rui ^b,c   Zhu, Gang Hua ^a   Xie, Ding Hua ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine   (China)

^d ETH ZURICH   (Switzerland)

Author keywords

Bone regeneration; Hydroxyapatite; Interleukin; Osteogenesis; Silk; Stem cell

Indexed keywords

BIOCOMPATIBILITY; BONE; CELL CULTURE; CELL SIGNALING; GENE EXPRESSION; HYDROXYAPATITE; NANOCOMPOSITES; POLYMERASE CHAIN REACTION; SILK; STEM CELLS; TISSUE REGENERATION;

BONE MARROW MESENCHYMAL STEM CELLS; BONE REGENERATION; CELL-BIOMATERIAL INTERACTIONS; DIFFERENTIALLY EXPRESSED GENE; GENE EXPRESSION LEVELS; INTERLEUKIN; OSTEOGENESIS; OSTEOINDUCTIVE EFFECTS;

SCAFFOLDS (BIOLOGY);

ALKALINE PHOSPHATASE BONE ISOENZYME; BONE MORPHOGENETIC PROTEIN 2; COMPLEMENTARY DNA; HYDROXYAPATITE; INTERLEUKIN 1 RECEPTOR TYPE II; INTERLEUKIN 1ALPHA; NANOCOMPOSITE; SILK FIBROIN; BIOMATERIAL; FIBROIN; NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; BIOCOMPATIBILITY; BONE DEVELOPMENT; BONE MARROW DERIVED MESENCHYMAL STEM CELL; BONE REGENERATION; CELL INTERACTION; CELL STRUCTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DNA MICROARRAY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; SCANNING ELECTRON MICROSCOPY; SKULL DEFECT; TISSUE SCAFFOLD; X RAY POWDER DIFFRACTION; ANIMAL; BONE MARROW CELL; CELL DIFFERENTIATION; CELL SHAPE; CHEMISTRY; CLUSTER ANALYSIS; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; SKULL; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALS; AUTOCRINE COMMUNICATION; BIOCOMPATIBLE MATERIALS; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEIN 2; BONE REGENERATION; CELL DIFFERENTIATION; CELL SHAPE; CLUSTER ANALYSIS; DISEASE MODELS, ANIMAL; DURAPATITE; FEMALE; FIBROINS; INTERLEUKIN-1ALPHA; MALE; MESENCHYMAL STROMAL CELLS; NANOPARTICLES; OSTEOGENESIS; PARACRINE COMMUNICATION; RATS, SPRAGUE-DAWLEY; RECEPTORS, INTERLEUKIN-1 TYPE II; SIGNAL TRANSDUCTION; SKULL; TISSUE SCAFFOLDS;

EID: 84924522534     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2015.01.017     Document Type: Article

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