Dose-response relationship between serum 2,3,7,8-tetrachlorodibenzo-p-dioxin and diabetes mellitus: A meta-analysis

American Journal of Epidemiology

Volumn 181, Issue 6, 2015, Pages 374-384

  Goodman, Michael ^a   Narayan, K M Venkat ^a   Flanders, Dana ^a   Chang, Ellen T ^b,c   Adami, Hans Olov ^d,e   Boffetta, Paolo ^f   Mandel, Jack S ^b  

^a EMORY UNIVERSITY   (United States)

^b EXPONENT INC   (United States)

^c STANFORD UNIVERSITY   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e KAROLINSKA INSTITUTE   (Sweden)

^f MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Agent Orange; diabetes mellitus; dioxin; dose response; heterogeneity; meta analysis; TCDD

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; POLLUTANT;

DIABETES; DOSE-RESPONSE RELATIONSHIP; HETEROGENEITY; META-ANALYSIS; REGRESSION ANALYSIS; SENSITIVITY ANALYSIS; SERUM; TCDD;

ARTICLE; BLOOD LEVEL; DIABETES MELLITUS; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; HUMAN; INCIDENCE; META ANALYSIS; RISK ASSESSMENT; BLOOD; POLLUTANT; PREVALENCE;

DIABETES MELLITUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL POLLUTANTS; HUMANS; INCIDENCE; PREVALENCE; TETRACHLORODIBENZODIOXIN;

EID: 84924425476     PISSN: 00029262     EISSN: 14766256     Source Type: Journal    
DOI: 10.1093/aje/kwu307     Document Type: Article

References (60)

1. Aylward LL, Brunet RC, Carrier G, et al. Concentrationdependent TCDD elimination kinetics in humans: toxicokinetic modeling for moderately to highly exposed adults from Seveso, Italy, and Vienna, Austria, and impact on dose estimates for the NIOSH cohort. J Expo Anal Environ Epidemiol. 2005;15(1): 51-65
2. Chen Q, Garabrant DH, Hedgeman E, et al. Estimation of background serum 2, 3, 7, 8-TCDD concentrations by using quantile regression in the UMDES and NHANES populations. Epidemiology. 2010;21(Suppl 4): S51-S57
3. Lorber M, Patterson D, Huwe J, et al. Evaluation of background exposures of Americans to dioxin-like compounds in the 1990s and the 2000s. Chemosphere. 2009;77(5):640-651
4. Garabrant DH, Franzblau A, Lepkowski J, et al. The University of Michigan Dioxin Exposure Study: predictors of human serum dioxin concentrations in Midland and Saginaw, Michigan. Environ Health Perspect. 2009;117(5):818-824
5. Akhtar FZ, Garabrant DH, Ketchum NS, et al. Cancer in US Air Force veterans of the Vietnam War. J Occup Environ Med. 2004;46(2):123-136
6. Michalek JE, Akhtar FZ, Arezzo JC, et al. Serum dioxin and peripheral neuropathy in veterans of Operation Ranch Hand. Neurotoxicology. 2001;22(4):479-490
7. Michalek JE, Akhtar FZ, Kiel JL. Serum dioxin, insulin, fasting glucose, and sex hormone-binding globulin in veterans of Operation Ranch Hand. J Clin Endocrinol Metab. 1999;84(5): 1540-1543
8. Michalek JE, Ketchum NS, Longnecker MP. Serum dioxin and hepatic abnormalities in veterans of Operation Ranch Hand. Ann Epidemiol. 2001;11(5):304-311
9. Michalek JE, Tripathi RC. Pharmacokinetics of TCDD in veterans of Operation Ranch Hand: 15-year follow-up. J Toxicol Environ Health A. 1999;57(6):369-378
10. Wolfe WH, Michalek JE, Miner JC, et al. Health status of Air Force veterans occupationally exposed to herbicides in Vietnam. I. Physical health. JAMA. 1990;264(14):1824-1831
11. Robinson J, Fox K, Elequin V, et al. Air Force Health Study Comprehensive Report: An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. Brooks AFB, TX: United States Air Force; Science Applications International Corporation; 2005
12. Henriksen GL, Ketchum NS, Michalek JE, et al. Serum dioxin and diabetes mellitus in veterans of Operation Ranch Hand. Epidemiology. 1997;8(3):252-258
13. Ketchum NS, Michalek JE. A Matched Analysis of Diabetes Mellitus and Herbicide Exposure in Veterans of Operation Ranch Hand. Brooks City-Base, TX: United States Air Force; 2006
14. Michalek JE, Ketchum NS, Tripathi RC. Diabetes mellitus and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin elimination in veterans of Operation Ranch Hand. J Toxicol Environ Health A. 2003; 66(3):211-221
15. Michalek JE, Pavuk M. Diabetes and cancer in veterans of Operation Ranch Hand after adjustment for calendar period, days of spraying, and time spent in Southeast Asia. J Occup Environ Med. 2008;50(3):330-340
16. Institute of Medicine. Veterans and Agent Orange: Herbicide/Dioxin Exposure and Type 2 Diabetes. Washington, DC: National Academies Press; 2000
17. Institute of Medicine. Veterans and Agent Orange: Update 2012. Washington, DC: National Academies Press; 2014
18. Neel BA, Sargis RM. The paradox of progress: environmental disruption of metabolism and the diabetes epidemic. Diabetes. 2011;60(7):1838-1848
19. Magliano DJ, Loh VH, Harding JL, et al. Persistent organic pollutants and diabetes: a review of the epidemiological evidence. Diabetes Metab. 2014;40(1):1-14
20. Remillard RB, Bunce NJ. Linking dioxins to diabetes: epidemiology and biologic plausibility. Environ Health Perspect. 2002;110(9):853-858
21. Taylor KW, Novak RF, Anderson HA, et al. Evaluation of the association between persistent organic pollutants (POPs) and diabetes in epidemiological studies: a national toxicology program workshop review. Environ Health Perspect. 2013; 121(7):774-783
22. IARCWorking Group on the Evaluation of Carcinogenic Risks to Humans: Polychlorinated Dibenzo-Para-Dioxins and Polychlorinated Dibenzofurans. Lyon, France, 4-11 February 1997. IARC Monogr Eval Carcinog Risks Hum. 1997;69:1-631
23. Il"yasova D, Hertz-Picciotto I, Peters U, et al. Choice of exposure scores for categorical regression in meta-analysis: a case study of a common problem. Cancer Causes Control. 2005;16(4):383-388
24. Warner M, Mocarelli P, Brambilla P, et al. Diabetes, metabolic syndrome, and obesity in relation to serum dioxin concentrations: the Seveso Women"s Health Study. Environ Health Perspect. 2013;121(8):906-911
25. Nakamoto M, Arisawa K, Uemura H, et al. Association between blood levels of PCDDs/PCDFs/dioxin-like PCBs and history of allergic and other diseases in the Japanese population. Int Arch Occup Environ Health. 2013;86(8):849-859
26. Sullivan KM, Dean A, Soe MM. OpenEpi: a web-based epidemiologic and statistical calculator for public health. Public Health Rep. 2009;124(3):471-474
27. Harbord RM, Higgins JPT. Meta-regression in Stata. Stata J. 2008;8(4):493-519
28. Greenland S, Longnecker MP. Methods for trend estimation from summarized dose-response data, with applications to meta-analysis. Am J Epidemiol. 1992;135(11):1301-1309
29. Larsson SC, Orsini N, Wolk A. Milk, milk products and lactose intake and ovarian cancer risk: a meta-analysis of epidemiological studies. Int J Cancer. 2006;118(2):431-441
30. Sutton AJ, Abrams KR, Jones DR, et al. Systematic reviews of trials and other studies. Health Technol Assess. 1998;2(19):1-276
31. Higgins JP, Thompson SG, Deeks JJ, et al. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-560
32. Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. Chichester, UK: Cochrane Collaboration and John Wiley & Sons; 2011
33. Egger M, Davey Smith G, Schneider M, et al. Bias in metaanalysis detected by a simple, graphical test. BMJ. 1997; 315(7109):629-634
34. Steenland K, Calvert G, Ketchum N, et al. Dioxin and diabetes mellitus: an analysis of the combined NIOSH and Ranch Hand data. Occup Environ Med. 2001;58(10):641-648
35. Zober A, Ott MG, Messerer P. Morbidity follow up study of BASF employees exposed to 2, 3, 7, 8-tetrachlorodibenzo-pdioxin (TCDD) after a 1953 chemical reactor incident. Occup Environ Med. 1994;51(7):479-486
36. Calvert GM, Sweeney MH, Deddens J, et al. Evaluation of diabetes mellitus, serum glucose, and thyroid function among United States workers exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Occup Environ Med. 1999;56(4):270-276
37. United States Air Force (USAF). Air Force Health Study Final Report: An Epidemiologic Investigation of Health Effects in Air Force Personnel Following Exposure to Herbicides. March 31, 2005. http://www.dtic.mil/cgi-bin/GetTRDoc?. AD=ADA438835&Location=U2&doc=GetTRDoc.pdf. Accessed May 10, 2014
38. Kang HK, Dalager NA, Needham LL, et al. Health status of Army Chemical Corps Vietnam veterans who sprayed defoliant in Vietnam. Am J Ind Med. 2006;49(11):875-884
39. Kim JS, Lim HS, Cho SI, et al. Impact of Agent Orange exposure among Korean Vietnam veterans. Ind Health. 2003; 41(3):149-157
40. Longnecker MP, Michalek JE. Serum dioxin level in relation to diabetes mellitus among Air Force veterans with background levels of exposure. Epidemiology. 2000;11(1):44-48
41. Eskenazi B, Mocarelli P, Warner M, et al. Seveso Women"s Health Study: Does zone of residence predict individual TCDD exposure?. Chemosphere. 2001;43(4-7):937-942
42. Glass GV. Primary, secondary, and meta-analysis of research. Educ Res. 1976;5(10):3-8
43. Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement. BMJ. 2009;339:b2535
44. Egger M, Smith GD, Sterne JA. Uses and abuses of meta-analysis. Clin Med. 2001;1(6):478-484
45. Davey Smith G, Egger M, Phillips AN. Meta-analysis. Beyond the grand mean?. BMJ. 1997;315(7122):1610-1614
46. Egger M, Smith GD. Meta-analysis. Potentials and promise. BMJ. 1997;315(7119):1371-1374
47. Greenland S. Can meta-analysis be salvaged?. Am J Epidemiol. 1994;140(9):783-787
48. Potischman N, Weed DL. Causal criteria in nutritional epidemiology. Am J Clin Nutr. 1999;69(6):1309S-1314S.
49. Rothman KJ, Greenland S. Causation and causal inference in epidemiology. Am J Public Health. 2005;95(Suppl 1): S144-S150
50. Kerger BD, Scott PK, Pavuk M, et al. Re-analysis of Ranch Hand study supports reverse causation hypothesis between dioxin and diabetes. Crit Rev Toxicol. 2012;42(8):669-687
51. Flanders WD, Lin L, Pirkle JL, et al. Assessing the direction of causality in cross-sectional studies. Am J Epidemiol. 1992; 135(8):926-935
52. Thomas EL, Frost G, Taylor-Robinson SD, et al. Excess body fat in obese and normal-weight subjects. Nutr Res Rev. 2012; 25(1):150-161
53. Fox CS, Massaro JM, Hoffmann U, et al. Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation. 2007;116(1):39-48
54. Thomas EL, Parkinson JR, Frost GS, et al. The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat. Obesity (Silver Spring). 2012;20(1):76-87
55. Patterson DG Jr, Hoffman RE, Needham LL, et al. 2, 3, 7, 8- Tetrachlorodibenzo-p-dioxin levels in adipose tissue of exposed and control persons in Missouri. An interim report. JAMA. 1986;256(19):2683-2686
56. Buffler PA, Ginevan ME, Mandel JS, et al. The Air Force Health Study: an epidemiologic retrospective. Ann Epidemiol. 2011;21(9):673-687
57. Pavuk M, Patterson DG Jr, Turner WE. Serum concentrations of TCDD and other dioxin-like compounds in US Air Force veterans of Operation Ranch Hand. Chemosphere. 2014;102: 18-23
58. Vena J, Boffetta P, Becher H, et al. Exposure to dioxin and nonneoplastic mortality in the expanded IARC international cohort study of phenoxy herbicide and chlorophenol production workers and sprayers. Environ Health Perspect. 1998; 106(Suppl 2):645-653
59. Collins JJ, Bodner K, Aylward LL, et al. Mortality rates among trichlorophenol workers with exposure to 2, 3, 7, 8- tetrachlorodibenzo-p-dioxin. Am J Epidemiol. 2009;170(4): 501-506
60. McBride DI, Collins JJ, Humphry NF, et al. Mortality in workers exposed to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin at a trichlorophenol plant in New Zealand. J Occup Environ Med. 2009;51(9):1049-1056