Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans

Cell Metabolism

Volumn 21, Issue 3, 2015, Pages 428-442

  Wei, Fan Yan ^a   Zhou, Bo ^a   Suzuki, Takeo ^b   Miyata, Keishi ^a   Ujihara, Yoshihiro ^c   Horiguchi, Haruki ^a   Takahashi, Nozomu ^a   Xie, Peiyu ^a   Michiue, Hiroyuki ^d   Fujimura, Atsushi ^d   Kaitsuka, Taku ^a   Matsui, Hideki ^d   Koga, Yasutoshi ^e   Mohri, Satoshi ^c   Suzuki, Tsutomu ^b   Oike, Yuichi ^a   Tomizawa, Kazuhito ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c KAWASAKI MEDICAL SCHOOL   (Japan)

^d OKAYAMA UNIVERSITY   (Japan)

^e KURUME UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLTHIO; CDK5 REGULATORY SUBUNIT ASSOCIATED PROTEIN 1; CYCLIN DEPENDENT KINASE 5; THIOL DERIVATIVE; TRANSFER RNA; UNCLASSIFIED DRUG; CDK5RAP1 PROTEIN, HUMAN; NERVE PROTEIN; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BASAL METABOLIC RATE; CATALYSIS; CHEMICAL MODIFICATION; CODON; HEART; HUMAN; MITOCHONDRION; MOUSE; MYOPATHY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SKELETAL MUSCLE; ANIMAL; C57BL MOUSE; CELL CULTURE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENETICS; KNOCKOUT MOUSE; MUSCLE DISEASE; RNA PROCESSING; TRANSGENIC MOUSE;

MAMMALIA; MUS;

ANIMALS; CELLS, CULTURED; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MITOCHONDRIA; MITOCHONDRIAL DISEASES; MUSCULAR DISEASES; NERVE TISSUE PROTEINS; OXIDATIVE STRESS; PROTEIN BIOSYNTHESIS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, TRANSFER;

EID: 84924408965     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2015.01.019     Document Type: Article

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