Alternative effector-function profiling identifies broad HIV-specific T-cell responses in highly HIV-exposed individuals who remain uninfected

Journal of Infectious Diseases

Volumn 211, Issue 6, 2015, Pages 936-946

  Ruiz Riol, Marta ^a   Llano, Anuska ^a   Ibarrondo, Javier ⁱ   Zamarreño, Jennifer ^a   Yusim, Karina ^j   Bach, Vanessa ^a   Mothe, Beatriz ^a,b,h   Perez Alvarez, Susana ^d   Fernandez, Marco A ^c   Requena, Gerard ^c   Meulbroek, Michael ^e   Pujol, Ferran ^e   Leon, Agathe ^f   Cobarsi, Patricia ^b   Korber, Bette T ^j   Clotet, Bonaventura ^a,b,h   Ganoza, Carmela ^k   Sanchez, Jorge ^k   Coll, Josep ^a,b   Brander, Christian ^a,g,h  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^c FUNDACIÓ INSTITUT D INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL   (Spain)

^d INOVA DIAGNOSTICS INC   (United States)

^e BCN Checkpoint Projecte Dels Noms   (Spain)

^f HOSPITAL CLÍNIC   (Spain)

^g INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

^h UNIVERSITY OF VIC CENTRAL UNIVERSITY OF CATALONIA   (Spain)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

^j LOS ALAMOS NATIONAL LABORATORY   (United States)

^k ASOCIACIÓN CIVIL IMPACTA SALUD Y EDUCACIÓN   (Peru)

more..

Author keywords

boosted flow cytometry; highly exposed seronegative; HIV infection; T cell responses; Th1 cytokines; Th17 cytokines; Th2 cytokines; toggled peptides

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 22; PEPTIDE;

ARTICLE; ASSAY; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; FLOW CYTOMETRY; HELPER CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOPATHOLOGY; INFECTION; INFECTION CONTROL; LYMPHOCYTE FUNCTION; PRIORITY JOURNAL; SERODIAGNOSIS; VIRUS RESISTANCE; CELL CULTURE; DISEASE RESISTANCE; IMMUNOLOGY; METABOLISM; SECRETION (PROCESS); VIROLOGY;

CELLS, CULTURED; CYTOKINES; DISEASE RESISTANCE; HIV; HUMANS; IMMUNITY, CELLULAR; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84924368748     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiu534     Document Type: Article

References (36)

1. Burgener A, Sainsbury J, Plummer FA, Ball TB. Systems biology-based approaches to understand HIV-exposed uninfected women. Curr HIV/AIDS Rep 2010; 7:53-9
2. Erickson AL, Willberg CB, McMahan V, et al. Potentially exposed but uninfected individuals produce cytotoxic and polyfunctional human immunodeficiency virus type 1-specific CD8(+) T-cell responses which can be defined to the epitope level. Clin Vaccine Immunol 2008; 15:1745-8
3. Goh WC, Markee J, Akridge RE, et al. Protection against human immunodeficiency virus type 1 infection in persons with repeated exposure: evidence for T cell immunity in the absence of inherited CCR5 coreceptor defects. J Infect Dis 1999; 179:548-57
4. Hasselrot K, Saberg P, Hirbod T, et al. Oral HIV-exposure elicits mucosal HIV-neutralizing antibodies in uninfected men who have sex with men. AIDS 2009; 23:329-33
5. Kaul R, Plummer FA, Kimani J, et al. HIV-1-specific mucosal CD8+ lymphocyte responses in the cervix of HIV-1-resistant prostitutes in Nairobi. J Immunol 2000; 164:1602-11
6. Schmechel SC, Russell N, Hladik F, et al. Immune defence against HIV- 1 infection in HIV-1-exposed seronegative persons. Immunol Lett 2001; 79:21-7
7. Addo MM, Altfeld M, Brainard DM, et al. Lack of detectable HIV-1- specific CD8(+) T cell responses in Zambian HIV-1-exposed seronegative partners of HIV-1-positive individuals. J Infect Dis 2011; 203: 258-62
8. Begaud E, Chartier L, Marechal V, et al. Reduced CD4T cell activation and in-vitro susceptibility to HIV-1 infection in exposed uninfected Central Africans. Retrovirology 2006; 3:35
9. Card CM, McLaren PJ, Wachihi C, Kimani J, Plummer FA, Fowke KR. Decreased immune activation in resistance to HIV-1 infection is associated with an elevated frequency of CD4(+)CD25(+)FOXP3(+) regulatory T cells. J Infect Dis 2009; 199:1318-22
10. Hladik F, Desbien A, Lang J, et al. Most highly exposed seronegative men lack HIV-1-specific, IFN-gamma-secreting T cells. J Immunol 2003; 171:2671-83
11. Koning FA, Otto SA, Hazenberg MD, et al. Low-level CD4+ T cell activation is associated with low susceptibility to HIV-1 infection. J Immunol 2005; 175:6117-22
12. Mothe B, Ibarrondo J, Llano A, Brander C. Virological, immune and host genetics markers in the control of HIV infection. Dis Markers 2009; 27:105-20
13. Pereyra F, Jia X, McLaren PJ, et al. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science 2010; 330:1551-7
14. Betts MR, Nason MC, West SM, et al. HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells. Blood 2006; 107:4781-9
15. Migueles SA, Tilton JC, Connors M. Qualitative host factors associated with immunological control of HIV infection by CD8T cells. Curr Opin HIV AIDS 2006; 1:28-33
16. Mothe B, Llano A, Ibarrondo J, et al. Definition of the viral targets of protective HIV-1-specific T cell responses. J Transl Med 2011; 9:208
17. Mothe B, Llano A, Ibarrondo J, et al. CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control. PLoS One 2012; 7:e29717
18. Frahm N, Korber BT, Adams CM, et al. Consistent cytotoxic- T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities. J Virol 2004; 78:2187-200
19. Brander C, Frahm N, Walker BD. The challenges of host and viral diversity in HIV vaccine design. Curr Opin Immunol 2006; 18:430-7
20. Brander C, Self S, Korber B. Capturing viral diversity for in-vitro test reagents and HIV vaccine immunogen design. Curr Opin HIV AIDS 2007; 2:183-8
21. Frahm N, Kaufmann DE, Yusim K, et al. Increased sequence diversity coverage improves detection of HIV-specific T cell responses. J Immunol 2007; 179:6638-50
22. Mackelprang RD, Baeten JM, Donnell D, et al. Quantifying ongoing HIV-1 exposure in HIV-1-serodiscordant couples to identify individuals with potential host resistance to HIV-1. J Infect Dis 2012; 206: 1299-308
23. Bihl F, Frahm N, Di Giammarino L, et al. Impact of HLA-B alleles, epitope binding affinity, functional avidity, and viral coinfection on the immunodominance of virus-specific CTL responses. J Immunol 2006; 176:4094-101
24. Lamoreaux L, Roederer M, Koup R. Intracellular cytokine optimization and standard operating procedure. Nat Protoc 2006; 1:1507-16
25. Roederer M, Nozzi JL, Nason MX. SPICE: Exploration and analysis of post-cytometric complex multivariate datasets. Cytometry A 2011; 79:167-74
26. Frahm N, Nickle DC, Linde CH, et al. Increased detection of HIVspecific T cell responses by combination of central sequences with comparable immunogenicity. AIDS 2008; 22:447-56
27. Kiepiela P, Ngumbela K, Thobakgale C, et al. CD8+ T-cell responses to different HIV proteins have discordant associations with viral load. Nat Med 2007; 13:46-53
28. Zuniga R, Lucchetti A, Galvan P, et al. Relative dominance of Gag p24- specific cytotoxic T lymphocytes is associated with human immunodeficiency virus control. J Virol 2006; 80:3122-5
29. Campion SL, Brodie TM, Fischer W, et al. Proteome-wide analysis of HIV-specific naive and memory CD4+ T cells in unexposed blood donors. J Exp Med 2014; 211:1273-80
30. Su LF, Kidd BA, Han A, Kotzin JJ, Davis MM. Virus-specific CD4(+) memory-phenotype T cells are abundant in unexposed adults. Immunity 2013; 38:373-83
31. Llano A. How to optimally define optimal cytotoxic T lymphocyte epitopes in HIV infection?. In: Korber B, Brander C, Walker B, et al , eds. HIV molecular immunology. Los Alamos, NM: Los Alamos National Laboratory: Theoretical Biology and Biophysics, 2009
32. Ritchie AJ, Campion SL, Kopycinski J, et al. Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals. J Virol 2011; 85:3507-16
33. Larsson M, Fonteneau JF, Lirvall M, Haslett P, Lifson JD, Bhardwaj N. Activation of HIV-1 specific CD4 and CD8T cells by human dendritic cells: roles for cross-presentation and non-infectious HIV-1 virus. AIDS 2002; 16:1319-29
34. Biasin M, Piacentini L, Lo Caputo S, et al. TLR activation pathways in HIV-1-exposed seronegative individuals. J Immunol 2010; 184:2710-7
35. Haynes BF, Gilbert PB, McElrath MJ, et al. Immune-correlates analysis of an HIV-1 vaccine efficacy trial. N Engl J Med 2012; 366: 1275-86
36. Misse D, Yssel H, Trabattoni D, et al. IL-22 participates in an innate anti-HIV-1 host-resistance network through acute-phase protein induction. J Immunol 2007; 178:407-15