Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels

Nature Communications

Volumn 6, Issue , 2015, Pages

  Van Leeuwen, Elisabeth M ^a   Karssen, Lennart C ^a   Deelen, Joris ^b   Isaacs, Aaron ^a   Medina Gomez, Carolina ^a   Mbarek, Hamdi ^c   Kanterakis, Alexandros ^d   Trompet, Stella ^b   Postmus, Iris ^b   Verweij, Niek ^d   Van Enckevort, David J ^e   Huffman, Jennifer E ^f   White, Charles C ^g   Feitosa, Mary F ^h   Bartz, Traci M ⁱ   Manichaikul, Ani ^j   Joshi, Peter K ^k   Peloso, Gina M ^l   Deelen, Patrick ^d   Van Dijk, Freerk ^d   Willemsen, Gonneke ^c   De Geus, Eco J ^c   Milaneschi, Yuri ^m   Penninx, Brenda W J H ^m   Francioli, Laurent C ⁿ   Menelaou, Androniki ⁿ   Pulit, Sara L ⁿ   Rivadeneira, Fernando ^a   Hofman, Albert ^a   Oostra, Ben A ^a   Franco, Oscar H ^a   Leach, Irene Mateo ^d   Beekman, Marian ^b   De Craen, Anton J M ^b   Uh, Hae Won ^b   Trochet, Holly ^f   Hocking, Lynne J ^o   Porteous, David J ^k   Sattar, Naveed ^p   Packard, Chris J ^q   Buckley, Brendan M ^r   Brody, Jennifer A ⁱ   Bis, Joshua C ⁱ   Rotter, Jerome I ^s   Mychaleckyj, Josyf C ^j   Campbell, Harry ^k   Duan, Qing ^t   Lange, Leslie A ^t   Wilson, James F ^k   Hayward, Caroline ^f   Polasek, Ozren ^u   Vitart, Veronique ^f   Rudan, Igor ^k   Wright, Alan F ^f   Rich, Stephen S ^j   Psaty, Bruce M ⁱ   Borecki, Ingrid B ^h   Kearney, Patricia M ^r   Stott, David J ^q   Cupples, L Adrienne ^g,v   Jukema, J Wouter ^b   Van Der Harst, Pim ^d   Sijbrands, Eric J ^a   Hottenga, Jouke Jan ^c   Uitterlinden, Andre G ^a   Swertz, Morris A ^d   Van Ommen, Gert Jan B ^b   De Bakker, Paul I W ⁿ   Eline Slagboom, P ^b   Boomsma, Dorret I ^w   Wijmenga, Cisca ^d   Van Duijn, Cornelia M ^a   Neerincx, Pieter B T ^d   Elbers, Clara C ⁿ   Palamara, Pier Francesco ^x   Peer, Itsik ^x,y   Abdellaoui, Abdel ^c   Kloosterman, Wigard P ⁿ   Van Oven, Mannis ^a   Vermaat, Martijn ^b   Li, Mingkun ^z   Laros, Jeroen F J ^b   Stoneking, Mark ^z   De Knijff, Peter ^b   Kayser, Manfred ^a   Veldink, Jan H ⁿ   Van Den Berg, Leonard H ⁿ   Byelas, Heorhiy ^d   Den Dunnen, Johan T ^b   Dijkstra, Martijn ^d   Amin, Najaf ^a   Van Der Velde, K Joeri ^d   Van Setten, Jessica ⁿ   Kattenberg, Mathijs ^c   Van Schaik, Barbera D C ^aa   Bot, Jan ^ab   Nijman, Isaäc J ⁿ   Mei, Hailiang ^e   Koval, Vyacheslav ^a   Ye, Kai ^b,h   Lameijer, Eric Wubbo ^b   Moed, Matthijs H ^b   Hehir Kwa, Jayne Y ^ac   Handsaker, Robert E ^ad,ae   Sunyaev, Shamil R ^ad,ae   Sohail, Mashaal ^ad,ae   Hormozdiari, Fereydoun ⁱ   Marschall, Tobias ^af   Schönhuth, Alexander ^af   Guryev, Victor ^d   Suchiman, H Eka D ^b   Wolffenbuttel, Bruce H ^d   Platteel, Mathieu ^d   Pitts, Steven J ^ag   Potluri, Shobha ^ag   Cox, David R ^ag   Li, Qibin ^ah   Li, Yingrui ^ah   Du, Yuanping ^ah   Chen, Ruoyan ^ah   Cao, Hongzhi ^ah   Li, Ning ^ah   Cao, Sujie ^ah   Wang, Jun ^ah,ai,aj   Bovenberg, Jasper A ^ak   more..

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^e BioAssist Netherlands Bioinformatics Center   (Netherlands)

^f UNIVERSITY OF EDINBURGH   (United Kingdom)

^g BOSTON UNIVERSITY   (United States)

^h WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ UNIVERSITY OF WASHINGTON   (United States)

^j UNIVERSITY OF VIRGINIA   (United States)

^k UNIVERSITY OF EDINBURGH   (United Kingdom)

^l MASSACHUSETTS GENERAL HOSPITAL   (United States)

^m VU UNIVERSITY MEDICAL CENTER   (Netherlands)

ⁿ UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^o UNIVERSITY OF ABERDEEN   (United Kingdom)

^p UNIVERSITY OF GLASGOW   (United Kingdom)

^q UNIVERSITY OF GLASGOW   (United Kingdom)

^r UNIVERSITY COLLEGE CORK   (Ireland)

^s HARBOR UCLA MEDICAL CENTER   (United States)

^t UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^u UNIVERSITY OF SPLIT   (Croatia)

^v FRAMINGHAM HEART STUDY   (United States)

^w VU UNIVERSITY AMSTERDAM   (Netherlands)

^x Max Planck Institute for Evolutionary Anthropology ^*  (United States)

^y Och Spine at New York Presbyterian Hospitals   (United States)

^z MAX PLANCK INSTITUTE FOR EVOLUTIONARY ANTHROPOLOGY   (Germany)

^aa ACADEMIC MEDICAL CENTER   (Netherlands)

^ab SURFSARA   (Netherlands)

^ac RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^ad BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^ae HARVARD MEDICAL SCHOOL   (United States)

^af CWI   (Netherlands)

^ag PFIZER INC   (United States)

^ah BGI SHENZHEN   (China)

^ai UNIVERSITY OF COPENHAGEN   (Denmark)

^aj Capital Region   (Denmark)

^ak Legal Pathways Institute for Health and Bio Law   (Netherlands)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER A6; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; TRIACYLGLYCEROL; ABC TRANSPORTER; ABCA6 PROTEIN, HUMAN;

FAT; GENE EXPRESSION; GENETIC ANALYSIS; GENOME; GENOMICS; MOLECULAR ANALYSIS; NUMERICAL MODEL;

ARTICLE; CHOLESTEROL BLOOD LEVEL; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC IDENTIFICATION; GENETIC VARIABILITY; HEREDITY; HUMAN; HUMAN GENOME; LIPID BLOOD LEVEL; MISSENSE MUTATION; NETHERLANDS; NEXT GENERATION SEQUENCING; PHENOTYPE; POPULATION GENETICS; PROTEIN FOLDING; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL SIGNIFICANCE; BLOOD; GENETIC ASSOCIATION STUDY; GENETICS; META ANALYSIS;

NETHERLANDS;

ATP-BINDING CASSETTE TRANSPORTERS; CHOLESTEROL; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; HUMANS; MUTATION, MISSENSE; NETHERLANDS;

EID: 84924363528     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms7065     Document Type: Article

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