The incorporation of bFGF mediated by heparin into PCL/gelatin composite fiber meshes for guided bone regeneration

Drug Delivery and Translational Research

Volumn 5, Issue 2, 2015, Pages 146-159

  Lee, Ji hye ^a   Lee, Young Jun ^a   Cho, Hyeong jin ^a   Kim, Dong Wan ^a   Shin, Heungsoo ^a  

^a Hanyang University   (South Korea)

Author keywords

Basic fibroblast growth factor; Electrospun; Growth factor delivery; Guided bone regeneration; Mesenchymal stem cells

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CD31 ANTIGEN; FIBROBLAST GROWTH FACTOR 2; GELATIN; HEPARIN; NANOCOMPOSITE; NANOFIBER; NANOMESH; POLYCAPROLACTONE; POLYESTER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE REGENERATION; CELL MIGRATION; CELL PROLIFERATION; CONJUGATION; CONTROLLED STUDY; CROSS LINKING; ELECTROSPINNING; HUMAN; HUMAN CELL; IMPLANTATION; MESENCHYMAL STEM CELL; MORPHOLOGY; MOUSE; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; UMBILICAL CORD BLOOD; ANGIOGENESIS; ANIMAL; CHEMISTRY; CHEMOTAXIS; DRUG DELIVERY SYSTEM; DRUG EFFECTS; INJURIES; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; MESENCHYMAL STROMA CELL; PATHOLOGY; PHYSIOLOGY; SKULL; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; BONE REGENERATION; CELL PROLIFERATION; CHEMOTAXIS; DRUG DELIVERY SYSTEMS; FIBROBLAST GROWTH FACTOR 2; GELATIN; HEPARIN; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MALE; MESENCHYMAL STROMAL CELLS; MICE, INBRED ICR; NEOVASCULARIZATION, PHYSIOLOGIC; POLYESTERS; SKULL;

EID: 84924361658     PISSN: 2190393X     EISSN: 21903948     Source Type: Journal    
DOI: 10.1007/s13346-013-0154-y     Document Type: Article

References (47)

1. Hermann JS, Buser D. Guided bone regeneration for dental implants. Curr Opin Periodontol. 1996;3:168–77.
2. Gerbi ME, Pinheiro AL, Marzola C, Limeira Junior Fde A, Ramalho LM, Ponzi EA, et al. Assessment of bone repair associated with the use of organic bovine bone and membrane irradiated at 830 nm. Photomed Laser Surg. 2005;23(4):382–8.
3. Gentile P, Chiono V, Tonda-Turo C, Ferreira AM, Ciardelli G. Polymeric membranes for guided bone regeneration. Biotechnol J. 2011;6(10):1187–97.
4. Simion M, Dahlin C, Blair K, Schenk RK. Effect of different microstructures of e-PTFE membranes on bone regeneration and soft tissue response: a histologic study in canine mandible. Clin Oral Implants Res. 1999;10(2):73–84.
5. Behring J, Junker R, Walboomers XF, Chessnut B, Jansen JA. Toward guided tissue and bone regeneration: morphology, attachment, proliferation, and migration of cells cultured on collagen barrier membranes. A systematic review. Odontol Soc Nippon Dent Univ. 2008;96(1):1–11.
6. Behr B, Sorkin M, Lehnhardt M, Renda A, Longaker MT, Quarto N. A comparative analysis of the osteogenic effects of BMP-2, FGF-2, and VEGFA in a calvarial defect model. Tissue Eng Part A. 2012;18(9–10):1079–86.
7. Hernandez A, Reyes R, Sanchez E, Rodriguez-Evora M, Delgado A, Evora C. In vivo osteogenic response to different ratios of BMP-2 and VEGF released from a biodegradable porous system. J Biomed Mater Res Part A. 2012;100(9):2382–91.
8. Zhang W, Wang X, Wang S, Zhao J, Xu L, Zhu C, et al. The use of injectable sonication-induced silk hydrogel for VEGF(165) and BMP-2 delivery for elevation of the maxillary sinus floor. Biomaterials. 2011;32(35):9415–24. doi:10.1016/j.biomaterials.2011.08.047.
9. Giraux JL, Matou S, Bros A, Tapon-Bretaudiere J, Letourneur D, Fischer AM. Modulation of human endothelial cell proliferation and migration by fucoidan and heparin. Eur J Cell Biol. 1998;77(4):352–9.
10. Perets A, Baruch Y, Weisbuch F, Shoshany G, Neufeld G, Cohen S. Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres. J Biomed Mater Res Part A. 2003;65(4):489–97. doi:10.1002/jbm.a.10542.
11. Lind M, Deleuran B, Thestrup-Pedersen K, Soballe K, Eriksen EF, Bunger C. Chemotaxis of human osteoblasts. APMIS Acta Pathol Microbiol Immunol Scand. 1995;103(2):140–6.
12. Hossain WA, Morest DK. Fibroblast growth factors (FGF-1, FGF-2) promote migration and neurite growth of mouse cochlear ganglion cells in vitro: immunohistochemistry and antibody perturbation. J Neurosci Res. 2000;62(1):40–55.
13. Murphy M, Drago J, Bartlett PF. Fibroblast growth factor stimulates the proliferation and differentiation of neural precursor cells in vitro. J Neurosci Res. 1990;25(4):463–75.
14. Ledoux D, Gannoun-Zaki L, Barritault D. Interactions of FGFs with target cells. Prog Growth Factor Res. 1992;4(2):107–20.
15. Gibran NS, Isik FF, Heimbach DM, Gordon D. Basic fibroblast growth factor in the early human burn wound. J Surg Res. 1994;56(3):226–34.
16. Mayahara H, Ito T, Nagai H, Miyajima H, Tsukuda R, Taketomi S, et al. In vivo stimulation of endosteal bone formation by basic fibroblast growth factor in rats. Growth Factors. 1993;9(1):73–80.
17. Montesano R, Vassalli JD, Baird A, Guillemin R, Orci L. Basic fibroblast growth factor induces angiogenesis in vitro. Proc Natl Acad Sci U S A. 1986;83(19):7297–301.
18. Nakamura T, Hanada K, Tamura M, Shibanushi T, Nigi H, Tagawa M, et al. Stimulation of endosteal bone formation by systemic injections of recombinant basic fibroblast growth factor in rats. Endocrinology. 1995;136(3):1276–84.
19. Nakasa T, Ishida O, Sunagawa T, Nakamae A, Yokota K, Adachi N, et al. Feasibility of prefabricated vascularized bone graft using the combination of FGF-2 and vascular bundle implantation within hydroxyapatite for osteointegration. J Biomed Mater Res Part A. 2008;85(4):1090–5. doi:10.1002/jbm.a.31673.
20. Bikfalvi A, Klein S, Pintucci G, Rifkin DB. Biological roles of fibroblast growth factor-2. Endocr Rev. 1997;18(1):26–45.
21. Tabata Y, Yamada K, Miyamoto S, Nagata I, Kikuchi H, Aoyama I, et al. Bone regeneration by basic fibroblast growth factor complexed with biodegradable hydrogels. Biomaterials. 1998;19(7–9):807–15.
22. Nakahara T, Nakamura T, Kobayashi E, Inoue M, Shigeno K, Tabata Y, et al. Novel approach to regeneration of periodontal tissues based on in situ tissue engineering: effects of controlled release of basic fibroblast growth factor from a sandwich membrane. Tissue Eng. 2003;9(1):153–62. doi:10.1089/107632703762687636.
23. Oh SA, Lee HY, Lee JH, Kim TH, Jang JH, Kim HW, et al. Collagen three-dimensional hydrogel matrix carrying basic fibroblast growth factor for the cultivation of mesenchymal stem cells and osteogenic differentiation. Tissue Eng Part A. 2012;18(9–10):1087–100. doi:10.1089/ten.TEA.2011.0360.
24. Jun I, Jeong S, Shin H. The stimulation of myoblast differentiation by electrically conductive sub-micron fibers. Biomaterials. 2009;30(11):2038–47.
25. Obata A, Hotta T, Wakita T, Ota Y, Kasuga T. Electrospun microfiber meshes of silicon-doped vaterite/poly(lactic acid) hybrid for guided bone regeneration. Acta Biomater. 2010;6(4):1248–57. doi:10.1016/j.actbio.2009.11.013.
26. Li WJ, Laurencin CT, Caterson EJ, Tuan RS, Ko FK. Electrospun nanofibrous structure: a novel scaffold for tissue engineering. J Biomed Mater Res. 2002;60(4):613–21.
27. Casper CL, Yamaguchi N, Kiick KL, Rabolt JF. Functionalizing electrospun fibers with biologically relevant macromolecules. Biomacromolecules. 2005;6(4):1998–2007.
28. Montero RB, Vial X, Nguyen DT, Farhand S, Reardon M, Pham SM, et al. bFGF-containing electrospun gelatin scaffolds with controlled nano-architectural features for directed angiogenesis. Acta Biomater. 2012;8(5):1778–91.
29. Sahoo S, Ang LT, Goh JC, Toh SL. Growth factor delivery through electrospun nanofibers in scaffolds for tissue engineering applications. J Biomed Mater Res Part A. 2010;93(4):1539–50. doi:10.1002/jbm.a.32645.
30. Kim MS, Bhang SH, Yang HS, Rim NG, Jun I, Kim SI, et al. Development of functional fibrous matrices for the controlled release of basic fibroblast growth factor to improve therapeutic angiogenesis. Tissue Eng Part A. 2010;16(10):2999–3010.
31. Kim MS, Shin YM, Lee JH, Kim SI, Nam YS, Shin CS, et al. Release kinetics and in vitro bioactivity of basic fibroblast growth factor: effect of the thickness of fibrous matrices. Macromol Biosci. 2011;11(1):122–30.
32. Sasisekharan R, Ernst S, Venkataraman G. On the regulation of fibroblast growth factor activity by heparin-like glycosaminoglycans. Angiogenesis. 1997;1(1):45–54.
33. Ishibe T, Goto T, Kodama T, Miyazaki T, Kobayashi S, Takahashi T. Bone formation on apatite-coated titanium with incorporated BMP-2/heparin in vivo. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(6):867–75.
34. Jeong SI, Jeon O, Krebs MD, Hill MC, Alsberg E. Biodegradable photo-crosslinked alginate nanofibre scaffolds with tuneable physical properties, cell adhesivity and growth factor release. Eur Cell Mater. 2012;24:331–43.
35. Liang HC, Chang Y, Hsu CK, Lee MH, Sung HW. Effects of crosslinking degree of an acellular biological tissue on its tissue regeneration pattern. Biomaterials. 2004;25(17):3541–52.
36. Chen YS, Chang JY, Cheng CY, Tsai FJ, Yao CH, Liu BS. An in vivo evaluation of a biodegradable genipin-cross-linked gelatin peripheral nerve guide conduit material. Biomaterials. 2005;26(18):3911–8.
37. Yao C-H, Liu B-S, Hsu S-H, Chen Y-S, Tsai C-C. Biocompatibility and biodegradation of a bone composite containing tricalcium phosphate and genipin crosslinked gelatin. J Biomed Mater Res Part A. 2004;69A(4):709–17. doi:10.1002/jbm.a.30045.
38. Kim MS, Jun I, Shin YM, Jang W, Kim SI, Shin H. The development of genipin-crosslinked poly(caprolactone) (PCL)/gelatin nanofibers for tissue engineering applications. Macromol Biosci. 2010;10(1):91–100.
39. Yoon JJ, Chung HJ, Park TG. Photo-crosslinkable and biodegradable pluronic/heparin hydrogels for local and sustained delivery of angiogenic growth factor. J Biomed Mater Res Part A. 2007;83(3):597–605. doi:10.1002/jbm.a.31271.
40. Shen H, Hu X, Yang F, Bei J, Wang S. Cell affinity for bFGF immobilized heparin-containing poly(lactide-co-glycolide) scaffolds. Biomaterials. 2011;32(13):3404–12. doi:10.1016/j.biomaterials.2011.01.037.
41. Tang D-W, Yu S-H, Ho Y-C, Mi F-L, Kuo P-L, Sung H-W. Heparinized chitosan/poly(γ-glutamic acid) nanoparticles for multi-functional delivery of fibroblast growth factor and heparin. Biomaterials. 2010;31(35):9320–32. doi:10.1016/j.biomaterials.2010.08.058.
42. Song G, Ju Y, Soyama H. Growth and proliferation of bone marrow mesenchymal stem cells affected by type I collagen, fibronectin and bFGF. Mater Sci Eng C. 2008;28(8):1467–71. doi:10.1016/j.msec.2008.04.005.
43. Tengood JE, Ridenour R, Brodsky R, Russell AJ, Little SR. Sequential delivery of basic fibroblast growth factor and platelet-derived growth factor for angiogenesis. Tissue Eng Part A. 2011;17(9–10):1181–9. doi:10.1089/ten.TEA.2010.0551.
44. Langer HF, Stellos K, Steingen C, Froihofer A, Schonberger T, Kramer B, et al. Platelet derived bFGF mediates vascular integrative mechanisms of mesenchymal stem cells in vitro. J Mol Cell Cardiol. 2009;47(2):315–25.
45. Chinen N, Tanihara M, Nakagawa M, Shinozaki K, Yamamoto E, Mizushima Y, et al. Action of microparticles of heparin and alginate crosslinked gel when used as injectable artificial matrices to stabilize basic fibroblast growth factor and induce angiogenesis by controlling its release. J Biomed Mater Res Part A. 2003;67(1):61–8.
46. Schmitz JP, Hollinger JO. The critical size defect as an experimental model for craniomandibulofacial nonunions. Clin Orthop Relat Res. 1986;205:299–308.
47. Hong KS, Kim EC, Bang SH, Chung CH, Lee YI, Hyun JK, et al. Bone regeneration by bioactive hybrid membrane containing FGF2 within rat calvarium. J Biomed Mater Res Part A. 2010;94(4):1187–94.