Feasibility of prefabricated vascularized bone graft using the combination of FGF-2 and vascular bundle implantation within hydroxyapatite for osteointegration

Journal of Biomedical Materials Research - Part A

Volumn 85, Issue 4, 2008, Pages 1090-1095

  Nakasa, Tomoyuki ^a   Ishida, Osamu ^a   Sunagawa, Toru ^a   Nakamae, Atsuo ^a   Yokota, Kazunori ^a   Adachi, Nobuo ^a   Ochi, Mitsuo ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Bone defect; Fibroblast growth factor; Interconnected porous calcium hydroxyapatite ceramic (IP CHA); Prefabrication; Vascular bundle

Indexed keywords

BONE; CELL GROWTH; FIBROBLASTS; GROWTH KINETICS; HYDROXYAPATITE; IMPLANTS (SURGICAL); TISSUE ENGINEERING;

BONE DEFECT; FIBROBLAST GROWTH FACTOR; INTERCONNECTED POROUS CALCIUM HYDROXYAPATITE CERAMIC (IP-CHA); PREFABRICATION; VASCULAR BUNDLE;

GRAFTS;

FIBROBLAST GROWTH FACTOR 2; HYDROXYAPATITE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERY; ARTICLE; BLOOD VESSEL; BONE GRAFT; FEMUR CONDYLE; FRACTURE HEALING; IMPLANTATION; MALE; NONHUMAN; OSSIFICATION; POROSITY; RABBIT; SAPHENOUS VEIN;

ANIMALS; BLOOD VESSELS; BONE AND BONES; BONE TRANSPLANTATION; DURAPATITE; FEASIBILITY STUDIES; FIBROBLAST GROWTH FACTOR 2; HUMANS; IMPLANTS, EXPERIMENTAL; MALE; OSSEOINTEGRATION; POROSITY; RABBITS;

EID: 44149112324     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.31673     Document Type: Article

References (24)

1. Chacha PB. Vascularized pedicular bone grafts. Int Orthop 1984;8:117-138.
2. Jupiter JB, Bour CJ, May JW Jr. The reconstruction of defects in the femoral shaft with vascularized transfers of fibular bone. J Bone Joint Surg Am 1987;69:365-374.
3. Shaffer JW, Field GA, Goldberg VM, Davy DT. Fate of vascularized and nonvascularized autografts. Clin Orthop 1985;197:32-43.
4. Sunagawa T, Bishop AT, Muramatsu K. Role of conventional and vascularized bone grafts in scaphoid nonunion with avascular necrosis: A canine experimental study. J Hand Surg Am 2000;25:849-859.
5. Weiland AJ, Phillips TW, Randolph MA. Bone grafts: A radiologic, histologic, and biomechanical model comparing autografts, allografts, and free vascularized bone grafts. Plast Reconstr Surg 1984;74:368-379.
6. Weiland AJ, Moore JR, Daniel RK. Vascularized bone autografts: Experience with 41 cases. Clin Orthop 1983;174:87-95.
7. Mizumoto S, Inada Y, Weiland AJ. Fabrication of vascularized bone grafts using ceramic chambers. J Reconstr Microsurg 1993;9:441-449.
8. Nettelblad H, Randolph MA, Östrup LT, Weiland AJ. Molded vascularized osteoneogenesis: A preliminary study in rabbits. Plast Reconstr Surg 1985;76:851-858.
9. Weiss AP, Olmedo ML, Lin JC, Ballock RT. Growth factor modulation of the formation of a molded vascularized bone graft in vivo. J Hand Surg Am 1995;20:94-100.
10. Kusumoto K, Bessho K, Fujimura K, Akioka J, Ogawa Y, Iizuka T. Prefabricated muscle flap including bone induced by recombinant bone morphogenetic protein-2: An experimental study of ectopic osteoinduction in a rat latissimus dorsi muscle flap. Br J Plast Surg 1998;51:275-280.
11. Terheyden H, Jepsen S, Rueger DR. Mandibular reconstruction in miniature pigs with prefabricated vascularized bone grafts using recombinant human osteogenic protein-1: A preliminary study. Int J Oral Maxillofac Surg 1999;28:461-463.
12. Vögelin MDE, Jones NF, Lieberman JR, Baker JM, Tsingotjidou AS, Brekke JH. Prefabrication of bone by use of a vascularized periosteal flap and bone morphogenetic protein. Plast Reconstr Surg 2001;109:190-198.
13. Tamai N, Myoui A, Tomita T, Nakase T, Tanaka J, Ochi T, Yosikawa H. Novel hydroxyapatite ceramics with an interconnective porus structure exhibit superior osteoconduction in vivo. J Biomed Mater Res 2001;59:110-117.
14. Akita S, Tamai N, Myoui A, Nishikawa M, Kaito T, Takaoka K, Yoshikawa H. Capillary vessel network integration by inserting a vascular pedicle enhances bone formation in tissue-engineered bone using interconnected porous hydroxyapatite ceramics. Tissue Eng 2004;10:789-795.
15. Nakasa T, Ishida O, Sunagawa T, Nakamae A, Yasunaga Y, Agung M, Ochi M. Prefabrication of vascularized bone graft using the combination of FGF-2 and vascular bundle implantation into a novel interconnected porous calcium hydroxyapatite ceramic. J Biomed Mater Res 2005;75:350-355.
16. Lederman RJ, Mendelsohn FO, Anderson RD, Saucedo JF, Tenaglia AN, Hermiller JB, Hillegass WB, Rocha-Singh K, Moon TE, Whitehouse MJ, Annex BH. Therapeutic angiogenesis with recombinant fibroblast growth factor-2 for intermittent claudication (the TRAFFIC study): A randomised trial. Lancet 2002;359:2053-2058.
17. Kubo S, Inui T, Hasegawa H, Yoshimine T. Repair of intractable cerebrospinal fluid rhinorrhea with mucosal flaps and recombinant human basic fibroblast growth factor: Technical case report. Neurosurgery 2005;56:E627.
18. Ren JM, Finklestein SP. Growth factor treatment of stroke. Curr Drug Targets CNS Neurol Disord 2005;4:121-125.
19. Adachi N, Ochi M, Deie M, Ito Y. Transplant of mesenchymal stem cells and hydroxyapatite ceramics to treat severe osteochondral damage after septic arthritis of the knee. J Rheumatol 2005;32:1615-1618.
20. Villanueva AR, Mehr LA. Modification of the Goldner and Gomori one-step trichrome stains for plastic-embedded thin sections of bone. Am J Med Technol 1977;43:536-538.
21. Gebhart M, Lane J. A radiographical and biomechanical study of demineralized bone matrix implanted into a bone defect of rat femurs with and without bone marrow. Acta Orthop Belg 1991;57:130-143.
22. Celik M, Tuncer S, Emekli U, Kestim SN. Histologic analysis of prefabricated, vascularized bone grafts: An experimental study in rabbits. J Oral Maxillofac Surg 2000;58:292-295.
23. Terheyden H, Knak C, Jepsen S, Palmie S, Rueger DR. Mandibular reconstruction with prefabricated vascularized bone grafts using recombinant human osteogenic protein-1: An experimental study in miniature pigs. I. Prefabrication. Int J Oral Maxillofac Surg 2001;30:373-379.
24. Terheyden H, Warnke P, Dunsche A, Jepsen S, Brenner W, Palmie S, Toth C, Rueger DR. Mandibular reconstruction with prefabricated vasculariezed bone grafts using recombinant human osteogenic protein-1: An experimental study in miniature pigs. II. Prefabrication. Int J Oral Maxillofac Surg 2001;30:469-478.