Clinical trial of Cecropia obtusifolia and Marrubium vulgare leaf extracts on blood glucose and serum lipids in type 2 diabetics

Phytomedicine

Volumn 11, Issue 7-8, 2004, Pages 561-566

  Herrera Arellano, A ^a   Aguilar Santamaria L ^a   Garcia Hernandez B ^a   Nicasio Torres, P ^a   Tortoriello, J ^a  

^a INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

Author keywords

Antilipemic agent; Cecropia obtusifolia; Diabetes mellitus type 2; Hypoglycemic agent; Marrubium vulgare

Indexed keywords

CECROPIA OBTUSIFOLIA EXTRACT; CHLOROGENIC ACID; CHOLESTEROL; GLUCOSE; LIPID; MARRUBIUM VULGARE EXTRACT; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; ANOREXIA; ARTICLE; CARBOHYDRATE METABOLISM; CECROPIA OBTUSIFOLIA; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG INFUSION; EVALUATION; FEMALE; GLUCOSE BLOOD LEVEL; HEARTBURN; HUMAN; HYPERSALIVATION; LIPID BLOOD LEVEL; LIPID METABOLISM; MALE; MARRUBIUM VULGARE; MEDICINAL PLANT; MEXICO; NAUSEA; NON INSULIN DEPENDENT DIABETES MELLITUS; OUTPATIENT; PLANT LEAF; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TRADITIONAL MEDICINE; TRIACYLGLYCEROL BLOOD LEVEL; XEROSTOMIA;

CECROPIA OBTUSIFOLIA; MARRUBIUM VULGARE;

EID: 10844286397     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2004.01.006     Document Type: Article

References (22)

1. Alberti, K.G.M.M., Gries, F.A., 1988. Management of non-insulin-dependent diabetes mellitus in Europe: a consensus view. Diabet. Med. 5, 275-281.
2. Andrade-Cetto, A., Wiedenfeld, H., 2001. Hypoglycemic effect of Cecropia obtusifolia on streptozotocin diabetic rats. J. Ethnopharmacol. 78, 145-149.
3. Argueta, V.A., Cano, A.L., Rodarte, M.E., 1994. Atlas de las Plantas de la Medicina Tradicional Mexicana. Instituto Nacional Indigenista, México.
4. De Jesus, R.A., Cechinel-Filho, V., Oliveira, A.E., Schlemper, V., 2000. Analysis of the antinociceptive properties of marrubiin isolated from Marrubium vulgare. Phytomedicine 7, 111-115.
5. Donnelly, R., Emslie-Smith, A.M., Gardner, J.D., Morris, A.D., 2000. ABC of arterial and venous disease. Vascular complications of diabetes. BMJ 320, 1062-1066.
6. El Bardai, S., Lyoussi, B., Wibo, M., Morel, N., 2001. Pharmacological evidence of hypotensive activity of Marrubium vulgare and Foeniculum vulgare in spontaneously hypertensive rat. Clin. Exp. Hypertens 23, 329-343.
7. El Bardai, S., Morel, N., Wibo, M., Fabre, N., Llabres, G., Lyoussi, B., Quetin-Leclercq, J., 2003. The vasorelaxant activity of marrubenol and marrubiin from Marrubium vulgare. Planta Med. 69, 75-77.
8. Freie, P.M., 1999. Mechanism and clinical effects of pioglitazone as a new agent for the treatment of Type-2 diabetes. Arzneimittelforschung 49, 835-842.
9. Jaouhari, J.T., Lazrek, H.B., Seddik, A., Jana, M., 1999. Hypoglicemic response to Zygophyllum gaetulum extracts in patients with non-insulin dependent diabetes mellitus. J. Ethnopharmacol. 64, 211-217.
10. Lopez-Alvarenga, J.C., Aguilar-Salinas, C.A., Velasco-Pérez, M.L., Arita-Melzer, O., Guillen, L.E., Wong, B., et al., 1999. Acarbose vs. bedtime NPH insulin in the treatment of secondary failures to sulphonylurea-metformin therapy in type 2 diabetes mellitus. Diabetes Obes. Metab. 1, 29-35.
11. Mughal, M.A., Jan, M., Maheri, W.M., Memon, M.Y., Ali, M., 2000. The effect of metformin on glycemic control, serum lipids and lipoproteins in diet alone and sulfonylurea-treated type 2 diabetic patients with sub-optimal metabolic control. J. Pakistan Med. Assoc. 50, 381-386.
12. Novaes, A.P., Rossi, C., Poffo, C., Pretti Jr., E., Oliveira, A.E., Schlemper, V., et al., 2001. Preliminary evaluation of the hypoglycemic effect of some Brazilian medicinal plants. Therapie 56, 427-430.
13. Perez-Guerrero, C., Herrera, M.D., Ortiz, R., Alvarez de Sotomayor, M., Fernandez, M.A., 2001. A pharmacological study of Cecropia obtusifolia Bertol aqueous extract. J. Ethnopharmacol. 76, 279-284.
14. Román, R.R., Flores, S.J., Partida, H.G., Lara, L.A., Alarcón, A.F., 1991. Experimental study of the hypoglycemic effect of some antidiabetic plants. Arch. Invest. Med. 22, 87-93.
15. Román, R.R., Alarcón, A.F., Lara, L.A., Flores, S.J., 1992. Hypoglycemic effect of plants used in Mexico as antidiabetics. Arch. Med. Res. 23, 59-64.
16. Rosen, E.D., Spiegelman, B.M., 2000. Peroxisome proliferator-activarted receptor γ ligands and atherosclerosis: ending the heartache. J. Clin. Invest. 106, 629-631.
17. Salas, I., Brenes, J.R., Morales, O.M., 1987. Antihypertensive effect of Cecropia obtusifolia (Moraceae) leaf extract on rats. Rev. Biol. Trop. 35, 127-130.
18. Sahpaz, S., Garbacki, N., Tits, M., Bailleul, F., 2002. Isolation and pharmacological activity of phenylpropanoid esters from Marrubium vulgare. J. Ethnopharmacol. 79, 389-392.
19. Secretaría de Salud, 2000. Proyecto de Modificación a la Norma oficial mexicana NOM-015-SSA2-1994 para la prevención, tratamiento y control de la diabetes. Rev. Med. IMSS 38, 477-495.
20. VanderJagt, T.J., Ghattas, R., VanderJagt, D.J., Crossey, M., Glew, R.H., 2002. Comparison of the total antioxidant content of 30 widely used medicinal plants of New Mexico. Life Sci. 70, 1035-1040.
21. Wolffenbuttel, B.H., Gomis, R., Squatrito, S., Jones, N.P., Patwardhan, R.N., 2000. Addition of low-dose rosiglitazone to sulphonylurea therapy improves glycaemic control in Type 2 diabetic patients. Diabet Med. 17, 40-47.
22. Yamasaki, Y., Kawamori, R., Wasada, T., Sato, O., Omori, Y., Eguchi, H., et al., 1997. Pioglitazone (AD-4833) ameliorates insulin resistance in patients with NIDDM. Tohoku J. Exp. Med. 183, 173-183.