Thrombocytopenia impairs host defense during murine streptococcus pneumoniae pneumonia

Critical Care Medicine

Volumn 43, Issue 3, 2015, Pages e75-e83

  Van Den Boogaard, Florry E ^a   Schouten, Marcel ^a   De Stoppelaar, Sacha F ^a   Roelofs, Joris J T H ^a   Brands, Xanthe ^a   Schultz, Marcus J ^a   Van'T Veer, Cornelis ^a   Van Der Poll, Tom ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Blood platelets; Inflammation; Lung; Pneumonia; Pneumoniae; Streptococcus; Thrombocytopenia

Indexed keywords

CLOPIDOGREL; ANTITHROMBIN III; ANTITHROMBIN III-PROTEASE COMPLEX; CYTOKINE; PEPTIDE HYDROLASE; PURINERGIC P2Y RECEPTOR ANTAGONIST; TICLOPIDINE;

ADVERSE OUTCOME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL LOAD; BLEEDING TIME; BLOOD CLOTTING; COMMUNITY ACQUIRED PNEUMONIA; COMPARATIVE STUDY; CONTROLLED STUDY; HISTOPATHOLOGY; HOST RESISTANCE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE; THROMBOCYTE; THROMBOCYTOPENIA; ANALOGS AND DERIVATIVES; ANIMAL; DISEASE MODEL; IMMUNOLOGY; METABOLISM; PATHOLOGY; PNEUMONIA, PNEUMOCOCCAL;

ANIMALS; ANTITHROMBIN III; CYTOKINES; DISEASE MODELS, ANIMAL; MICE; PEPTIDE HYDROLASES; PNEUMONIA, PNEUMOCOCCAL; PURINERGIC P2Y RECEPTOR ANTAGONISTS; STREPTOCOCCUS PNEUMONIAE; THROMBOCYTOPENIA; TICLOPIDINE;

EID: 84924330133     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000853     Document Type: Article

References (51)

1. Mandell LA, Wunderink RG, Anzueto A, et al; Infectious Diseases Society of America; American Thoracic Society: Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis 2007; 44(Suppl 2):S27-S72
2. Opal SM, Garber GE, LaRosa SP, et al: Systemic host responses in severe sepsis analyzed by causative microorganism and treatment effects of drotrecogin alfa (activated). Clin Infect Dis 2003; 37:50-58
3. Prevention of pneumococcal disease: Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 1997; 46(RR-8):1-24
4. Welte T, Torres A, Nathwani D: Clinical and economic burden of community- acquired pneumonia among adults in Europe. Thorax 2012; 67:71-79
5. Baughman RP, Lower EE, Flessa HC, et al: Thrombocytopenia in the intensive care unit. Chest 1993; 104:1243-1247
6. Strauss R, Wehler M, Mehler K, et al: Thrombocytopenia in patients in the medical intensive care unit: Bleeding prevalence, transfusion requirements, and outcome. Crit Care Med 2002; 30:1765-1771
7. Vanderschueren S, De Weerdt A, Malbrain M, et al: Thrombocytopenia and prognosis in intensive care. Crit Care Med 2000; 28:1871-1876
8. Brogly N, Devos P, Boussekey N, et al: Impact of thrombocytopenia on outcome of patients admitted to ICU for severe communityacquired pneumonia. J Infect 2007; 55:136-140
9. Bozza FA, Shah AM, Weyrich AS, et al: Amicus or adversary: Platelets in lung biology, acute injury, and inflammation. Am J Respir Cell Mol Biol 2009; 40:123-134
10. Semple JW, Freedman J: Platelets and innate immunity. Cell Mol Life Sci 2010; 67:499-511
11. Yeaman MR: Platelets in defense against bacterial pathogens. Cell Mol Life Sci 2010; 67:525-544
12. Clark SR, Ma AC, Tavener SA, et al: Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 2007; 13:463-469
13. Andonegui G, Kerfoot SM, McNagny K, et al: Platelets express functional Toll-like receptor-4. Blood 2005; 106:2417-2423
14. Stohlawetz P, Folman CC, von dem Borne AE, et al: Effects of endotoxemia on thrombopoiesis in men. Thromb Haemost 1999; 81:613-617
15. Tacchini-Cottier F, Vesin C, Redard M, et al: Role of TNFR1 and TNFR2 in TNF-induced platelet consumption in mice. J Immunol 1998; 160:6182-6186
16. Looney MR, Nguyen JX, Hu Y, et al: Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury. J Clin Invest 2009; 119:3450-3461
17. Schneider RC, Zapol WM, Carvalho AC: Platelet consumption and sequestration in severe acute respiratory failure. Am Rev Respir Dis 1980; 122:445-451
18. Asaduzzaman M, Lavasani S, Rahman M, et al: Platelets support pulmonary recruitment of neutrophils in abdominal sepsis. Crit Care Med 2009; 37:1389-1396
19. Kornerup KN, Salmon GP, Pitchford SC, et al: Circulating platelet-neutrophil complexes are important for subsequent neutrophil activation and migration. J Appl Physiol (1985) 2010; 109:758-767
20. Zarbock A, Singbartl K, Ley K: Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. J Clin Invest 2006; 116:3211-3219
21. Asaduzzaman M, Rahman M, Jeppsson B, et al: P-selectin glycoprotein- ligand-1 regulates pulmonary recruitment of neutrophils in a platelet-independent manner in abdominal sepsis. Br J Pharmacol 2009; 156:307-315
22. Tweardy DJ, Khoshnevis MR, Yu B, et al: Essential role for platelets in organ injury and inflammation in resuscitated hemorrhagic shock. Shock 2006; 26:386-390
23. Aslam R, Speck ER, Kim M, et al: Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo. Blood 2006; 107:637-641
24. Yeaman MR, Tang YQ, Shen AJ, et al: Purification and in vitro activities of rabbit platelet microbicidal proteins. Infect Immun 1997; 65:1023-1031
25. Youssefian T, Drouin A, Massé JM, et al: Host defense role of platelets: Engulfment of HIV and Staphylococcus aureus occurs in a specific subcellular compartment and is enhanced by platelet activation. Blood 2002; 99:4021-4029
26. Yeaman MR: The role of platelets in antimicrobial host defense. Clin Infect Dis 1997; 25:951-968; quiz 969-970
27. Weyrich AS, Elstad MR, McEver RP, et al: Activated platelets signal chemokine synthesis by human monocytes. J Clin Invest 1996; 97:1525-1534
28. Wong CH, Jenne CN, Petri B, et al: Nucleation of platelets with blood-borne pathogens on Kupffer cells precedes other innate immunity and contributes to bacterial clearance. Nat Immunol 2013; 14:785-792
29. Tang YQ, Yeaman MR, Selsted ME: Antimicrobial peptides from human platelets. Infect Immun 2002; 70:6524-6533
30. Yeaman MR, Bayer AS: Antimicrobial peptides from platelets. Drug Resist Updat 1999; 2:116-126
31. Van Den Boogaard FE, Brands X, Schultz MJ, et al: Recombinant human tissue factor pathway inhibitor exerts anticoagulant, anti-inflammatory and antimicrobial effects in murine pneumococcal pneumonia. J Thromb Haemost 2011; 9:122-132
32. Chi X, Zhi L, Gelderman MP, et al: Host platelets and, in part, neutrophils mediate lung accumulation of transfused UVB-irradiated human platelets in a mouse model of acute lung injury. PLoS One 2012; 7:e44829
33. Goerge T, Ho-Tin-Noe B, Carbo C, et al: Inflammation induces hemorrhage in thrombocytopenia. Blood 2008; 111:4958-4964
34. Polanowska-Grabowska R, Wallace K, Field JJ, et al: P-selectin-mediated platelet-neutrophil aggregate formation activates neutrophils in mouse and human sickle cell disease. Arterioscler Thromb Vasc Biol 2010; 30:2392-2399
35. Savi P, Zachayus JL, Delesque-Touchard N, et al: The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Proc Natl Acad Sci U S A 2006; 103:11069-11074
36. Knapp S, Wieland CW, van't Veer C, et al: Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense. J Immunol 2004; 172:3132-3138
37. Kager LM, Wiersinga WJ, Roelofs JJ, et al: Plasminogen activator inhibitor type I contributes to protective immunity during experimental Gram-negative sepsis (melioidosis). J Thromb Haemost 2011; 9:2020-2028
38. Monroe DM, Hoffman M, Roberts HR: Platelets and thrombin generation. Arterioscler Thromb Vasc Biol 2002; 22:1381-1389
39. Dall L, Miller T, Herndon B, et al: Platelet depletion and severity of streptococcal endocarditis. Can J Infect Dis 1998; 9:359-366
40. Garcia JG, Liu F, Verin AD, et al: Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J Clin Invest 2001; 108:689-701
41. Lo SK, Burhop KE, Kaplan JE, et al: Role of platelets in maintenance of pulmonary vascular permeability to protein. Am J Physiol 1988; 254(4, Part 2):H763-H771
42. Khan AI, Heit B, Andonegui G, et al: Lipopolysaccharide: A p38 MAPK-dependent disrupter of neutrophil chemotaxis. Microcirculation 2005; 12:421-432
43. Zimmerman TS, Spiegelberg HL: Pneumococcus-induced serotonin release from human platelets. Identification of the participating plasma/ serum factor as immunoglobulin. J Clin Invest 1975; 56:828-834
44. Xiang B, Zhang G, Guo L, et al: Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway. Nat Commun 2013; 4:2657
45. Boulaftali Y, Hess PR, Getz TM, et al: Platelet ITAM signaling is critical for vascular integrity in inflammation. J Clin Invest 2013; 123:908-916
46. Grommes J, Alard JE, Drechsler M, et al: Disruption of platelet-derived chemokine heteromers prevents neutrophil extravasation in acute lung injury. Am J Respir Crit Care Med 2012; 185: 628-636
47. Levi M, de Jonge E, van der Poll T: Plasma and plasma components in the management of disseminated intravascular coagulation. Best Pract Res Clin Haematol 2006; 19:127-142
48. Geelen S, Bhattacharyya C, Tuomanen E: Induction of procoagulant activity on human endothelial cells by Streptococcus pneumoniae. Infect Immun 1992; 60:4179-4183
49. Levi M: Platelets in sepsis. Hematology 2005; 10(Suppl 1):129-131
50. Keane C, Tilley D, Cunningham A, et al: Invasive Streptococcus pneumoniae trigger platelet activation via Toll-like receptor 2. J Thromb Haemost 2010; 8:2757-2765
51. Winning J, Reichel J, Eisenhut Y, et al: Anti-platelet drugs and outcome in severe infection: Clinical impact and underlying mechanisms. Platelets 2009; 20:50-57