Oxytocin prevents ethanol actions at δ subunit-containing GABAA receptors and attenuates ethanol-induced motor impairment in rats

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 10, 2015, Pages 3104-3109

  Bowen, Michael T ^a   Peters, Sebastian T ^b   Absalom, Nathan ^a   Chebib, Mary ^a   Neumann, Inga D ^b   McGregor, Iain S ^a  

^a UNIVERSITY OF SYDNEY   (Australia)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Alcohol; Electrophysiology; GABA; Motor impairment; Oxytocin

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR DELTA; ALCOHOL; ARGIPRESSIN; GABOXADOL; OXYTOCIN; UNCLASSIFIED DRUG; VASOPRESSIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CEREBROSPINAL FLUID ANALYSIS; ELECTROPHYSIOLOGICAL PROCEDURES; IN VITRO STUDY; IN VIVO STUDY; MALE; MOTOR DYSFUNCTION; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; RAT; RIGHTING REFLEX TEST; SEDATION; VOLTAGE CLAMP TECHNIQUE; XENOPUS; ANIMAL; DRUG EFFECTS; INTRASPINAL DRUG ADMINISTRATION; MOTOR ACTIVITY; WISTAR RAT;

RATTUS;

ANIMALS; ETHANOL; INJECTIONS, SPINAL; MALE; MOTOR ACTIVITY; OXYTOCIN; RATS; RATS, WISTAR; RECEPTORS, GABA-A;

EID: 84924308119     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1416900112     Document Type: Article

References (51)

1. A receptors: Their function in the CNS and implications for disease. Neuron 73(1):23-34.
2. A receptor activity. Nat Neurosci 8(3):339-345.
3. Areceptors are reversed by the behavioral alcohol antagonist Ro15-4513. Proc Natl Acad Sci USA 103(22):8540-8545.
4. A receptor plasticity after ethanol intoxication. J Neurosci 27(45):12367-12377.
5. Mihalek RM, et al. (2001) GABA(A)-receptor δ subunit knockout mice have multiple defects in behavioral responses to ethanol. Alcohol Clin Exp Res 25(12):1708-1718.
6. A receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake. Proc Natl Acad Sci USA 108(11):4459-4464.
7. Wallner M, Hanchar HJ, Olsen RW (2003) Ethanol enhances α4β3δ and α6β3δγ-aminobutyric acid type A receptors at low concentrations known to affect humans. Proc Natl Acad Sci USA 100(25):15218-15223.
8. A receptors. Proc Natl Acad Sci USA 103(22):8546-8551.
9. Neumann ID, Landgraf R (2012) Balance of brain oxytocin and vasopressin: Implications for anxiety, depression, and social behaviors. Trends Neurosci 35(11):649-659.
10. Puciłowski O, Kostowski W, Trzaskowska E (1985) The effect of oxytocin and fragment (MIF-I) on the development of tolerance to hypothermic and hypnotic action of ethanol in the rat. Peptides 6(1):7-10.
11. Szabó G, Kovács GL, Telegdy G (1987) Effects of neurohypophyseal peptide hormones on alcohol dependence and withdrawal. Alcohol Alcohol 22(1):71-74.
12. Bowen MT, Carson DS, Spiro A, Arnold JC, McGregor IS (2011) Adolescent oxytocin exposure causes persistent reductions in anxiety and alcohol consumption and enhances sociability in rats. PLoS ONE 6(11):e27237.
13. Pedersen CA, et al. (2013) Intranasal oxytocin blocks alcohol withdrawal in human subjects. Alcohol Clin Exp Res 37(3):484-489.
14. Kovács GL, Sarnyai Z, Szabó G (1998) Oxytocin and addiction: A review. Psychoneuroendocrinology 23(8):945-962.
15. Meera P, Wallner M, Otis TS (2011) Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors. J Neurophysiol 106(4):2057-2064.
16. Walker BM, Ehlers CL (2009) Age-related differences in the blood alcohol levels of Wistar rats. Pharmacol Biochem Behav 91(4):560-565.
17. Davson H (1969) The cerebrospinal fluid. Handbook of Neurochemistry, ed Lajtha A (Springer, New York), pp 23-48.
18. Meyer-Lindenberg A, Domes G, Kirsch P, Heinrichs M (2011) Oxytocin and vasopressin in the human brain: Social neuropeptides for translational medicine. Nat Rev Neurosci 12(9):524-538.
19. McGregor IS, Bowen MT (2012) Breaking the loop: Oxytocin as a potential treatment for drug addiction. Horm Behav 61(3):331-339.
20. Zanos P, et al. (2014) The oxytocin analogue carbetocin prevents emotional impairment and stress-induced reinstatement of opioid-seeking in morphine-abstinent mice. Neuropsychopharmacology 39(4):855-865.
21. Buisman-Pijlman FT, et al. (2014) Individual differences underlying susceptibility to addiction: Role for the endogenous oxytocin system. Pharmacol Biochem Behav 119:22-38.
22. Sarnyai Z (2011) Oxytocin as a potential mediator and modulator of drug addiction. Addict Biol 16(2):199-201.
23. McGregor IS, Bowen MT (2013) Oxytocin and addiction: Recent preclinical advances and future clinical potential. Oxytocin, Vasopressin and Related Peptides in the Regulation of Behavior, eds Choleris E, Pfaff DW, Kavaliers M (Cambridge Univ Press, Cambridge, UK), pp 270-287.
24. A receptor subtypes: The "one glass of wine" receptors. Alcohol 41(3):201-209.
25. Areceptor subunit mRNAs in the rat brain. I. Telencephalon, diencephalon, mesencephalon. J Neurosci 12(3):1040-1062.
26. A receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J Neurosci 12(3):1063-1076.
27. Sundstrom-Poromaa I, et al. (2002) Hormonally regulated α(4)β(2)δ GABA(A) receptors are a target for alcohol. Nat Neurosci 5(8):721-722.
28. Karim N, et al. (2012) Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors. Biochem Pharmacol 84(4):549-557.
29. Eaton MM, et al. (2014) γ-aminobutyric acid type A α4, β2, and δ subunits assemble to produce more than one functionally distinct receptor type. Mol Pharmacol 86(6):647-656.
30. Borghese CM, et al. (2006) The δ subunit of γ-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol. J Pharmacol Exp Ther 316(3):1360-1368.
31. Kimura T, Tanizawa O, Mori K, Brownstein MJ, Okayama H (1992) Structure and expression of a human oxytocin receptor. Nature 356(6369):526-529.
32. Ramos L, et al. (2013) Acute prosocial effects of oxytocin and vasopressin when given alone or in combination with 3,4-methylenedioxymethamphetamine in rats: Involvement of the V1A receptor. Neuropsychopharmacology 38(11):2249-2259.
33. Sala M, et al. (2011) Pharmacologic rescue of impaired cognitive flexibility, social deficits, increased aggression, and seizure susceptibility in oxytocin receptor null mice: A neurobehavioral model of autism. Biol Psychiatry 69(9):875-882.
34. Bowen MT, McGregor IS (2014) Oxytocin and vasopressin modulate the social response to threat: A preclinical study. Int J Neuropsychopharmacol 17(10):1621-1633.
35. Song Z, et al. (2014) Oxytocin induces social communication by activating argininevasopressin V1a receptors and not oxytocin receptors. Psychoneuroendocrinology 50:14-19.
36. Suraev AS, et al. (2014) Adolescent exposure to oxytocin, but not the selective oxytocin receptor agonist TGOT, increases social behavior and plasma oxytocin in adulthood. Horm Behav 65(5):488-496.
37. Koksma JJ, et al. (2003) Oxytocin regulates neurosteroid modulation of GABA(A) receptors in supraoptic nucleus around parturition. J Neurosci 23(3):788-797.
38. Tyzio R, et al. (2006) Maternal oxytocin triggers a transient inhibitory switch in GABA signaling in the fetal brain during delivery. Science 314(5806):1788-1792.
39. Tyzio R, et al. (2014) Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring. Science 343(6171):675-679.
40. Suzdak PD, et al. (1986) A selective imidazobenzodiazepine antagonist of ethanol in the rat. Science 234(4781):1243-1247.
41. Harris CM, Benjamin D, Lal H (1987) Anxiety-like subjective effect of ethanol antagonist RO 15-4513 demonstrated in pentylenetetrazol discrimination. Neuropharmacology 26(10):1545-1547.
42. Mhatre MC, Gonzalez LP (1999) Increased Ro15-4513-induced seizures following multiple ethanol withdrawals. Pharmacol Biochem Behav 63(1):93-99.
43. NHMRC (2004) Australian Code of Practice for the Care and Use of Animals for Scientific Purposes (National Health and Medical Research Council, Canberra, ACT, Australia), 7th Ed.
44. National Research Council (2011) Guide for the Care and Use of Laboratory Animals (National Academies Press, Washington, DC), 8th Ed.
45. Shukitt-Hale B, Mouzakis G, Joseph JA (1998) Psychomotor and spatial memory performance in aging male Fischer 344 rats. Exp Gerontol 33(6):615-624.
46. Boyce-Rustay JM, Holmes A (2006) Ethanol-related behaviors in mice lacking the NMDA receptor NR2A subunit. Psychopharmacology (Berl) 187(4):455-466.
47. Crabbe JC, et al. (2003) Strain differences in three measures of ethanol intoxication in mice: the screen, dowel and grip strength tests. Genes Brain Behav 2(4):201-213.
48. Little PJ, Kuhn CM, Wilson WA, Swartzwelder HS (1996) Differential effects of ethanol in adolescent and adult rats. Alcohol Clin Exp Res 20(8):1346-1351.
49. Correa M, Arizzi MN, Betz A, Mingote S, Salamone JD (2003) Open field locomotor effects in rats after intraventricular injections of ethanol and the ethanol metabolites acetaldehyde and acetate. Brain Res Bull 62(3):197-202.
50. Keene ON (1995) The log transformation is special. Stat Med 14(8):811-819.
51. Absalom N, et al. (2012) α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). Proc Natl Acad Sci USA 109(33):13404-13409.