Decreased BECN1 mRNA Expression in Human Breast Cancer is Associated With Estrogen Receptor-Negative Subtypes and Poor Prognosis

EBioMedicine

Volumn 2, Issue 3, 2015, Pages 255-263

  Tang, Hao ^a   Sebti, Salwa ^a,b   Titone, Rossella ^a,b,c   Zhou, Yunyun ^a   Isidoro, Ciro ^c   Ross, Theodora S ^b,d   Hibshoosh, Hanina ^e   Xiao, Guanghua ^a   Packer, Milton ^a   Xie, Yang ^a,d   Levine, Beth ^a,b,d  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e NONE   (United States)

Author keywords

Autophagy; BECN1; BRCA1; Breast cancer

Indexed keywords

BECLIN 1; BRCA1 ASSOCIATED RING DOMAIN PROTEIN 1; ESTROGEN RECEPTOR; MESSENGER RNA; PROTEIN P53;

ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER PROGNOSIS; CANCER SUSCEPTIBILITY; CELL PROLIFERATION; COPY NUMBER VARIATION; DNA DAMAGE; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE MUTATION; HUMAN; IMMUNOHISTOCHEMISTRY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL;

EID: 84924300470     PISSN: None     EISSN: 23523964     Source Type: Journal    
DOI: 10.1016/j.ebiom.2015.01.008     Document Type: Article

References (51)

1. Aita V.M., Liang X.H., Murty V.V., et al. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 1999, 59:59-65.
2. Akavia U.D., Litvin O., Kim J., et al. An integrated approach to uncover drivers of cancer. Cell 2010, 143:1005-1017.
3. Anon. Comprehensive molecular portraits of human breast tumours. Nature 2012, 490:61-70.
4. Birgisdottir V., Stefansson O.A., Bodvarsdottir S.K., Hilmarsdottir H., Jonasson J.G., Eyfjord J.E. Epigenetic silencing and deletion of the BRCA1 gene in sporadic breast cancer. Breast Cancer Res. 2006, 8:R38.
5. Cheng C.L., Hou H.A., Lee M.C., et al. Higher bone marrow LGALS3 expression is an independent unfavorable prognostic factor for overall survival in patients with acute myeloid leukemia. Blood 2013, 121:3172-3180.
6. Cicchini M., Chakrabarti R., Kongara S., et al. Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity. Autophagy 2014, 10.
7. Curtis C., Shah S.P., Chin S.F., et al. The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature 2012, 486:346-352.
8. Dong M., Wan X.B., Yuan Z.Y., et al. Low expression of Beclin 1 and elevated expression of HIF-1alpha refine distant metastasis risk and predict poor prognosis of ER-positive, HER2-negative breast cancer. Med. Oncol. 2013, 30:355.
9. Evers B., Jonkers J. Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects. Oncogene 2006, 25:5885-5897.
10. Foulkes W.D., Stefansson I.M., Chappuis P.O., et al. Germline BRCA1 mutations and a basal epithelial phenotype in breast cancer. J. Natl. Cancer Inst. 2003, 95:1482-1485.
11. Funderburk S.F., Wang Q.J., Yue Z. The Beclin 1-VPS34 complex-at the crossroads of autophagy and beyond. Trends Cell Biol. 2010, 20:355-362.
12. Futreal P.A., Liu Q., Shattuck-Eidens D., et al. BRCA1 mutations in primary breast and ovarian carcinomas. Science 1994, 266:120-122.
13. Garcia A.I., Buisson M., Bertrand P., et al. Down-regulation of BRCA1 expression by miR-146a and miR-146b-5p in triple negative sporadic breast cancers. EMBO Mol. Med. 2011, 3:279-290.
14. Han J., Hou W., Lu C., et al. Interaction between Her2 and Beclin-1 proteins underlies a new mechanism of reciprocal regulation. J. Biol. Chem. 2013, 288:20315-20325.
15. Joosse S.A., Brandwijk K.I., Mulder L., Wesseling J., Hannemann J., Nederlof P.M. Genomic signature of BRCA1 deficiency in sporadic basal-like breast tumors. Genes Chromosomes Cancer 2011, 50:71-81.
16. Laddha S.V., Ganesan S., Chan C.S., White E. Mutational landscape of the essential autophagy gene BECN1 in human cancers. Mol. Cancer Res. 2014, 12:485-490.
17. Latimer J.J., Rubinstein W.S., Johnson J.M., Kanbour-Shakir A., Vogel V.G., Grant S.G. Haploinsufficiency for BRCA1 is associated with normal levels of DNA nucleotide excision repair in breast tissue and blood lymphocytes. BMC Med. Genet. 2005, 6:26.
18. Lawrence M.S., Stojanov P., Polak P., et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 2013, 499:214-218.
19. Lee J.S., Fackler M.J., Lee J.H., et al. Basal-like breast cancer displays distinct patterns of promoter methylation. Cancer Biol. Ther. 2010, 9:1017-1024.
20. Levine B., Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008, 132:27-42.
21. Li Z., Chen B., Wu Y., Jin F., Xia Y., Liu X. Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors. BMC Cancer 2010, 10:98.
22. Liang X.H., Jackson S., Seaman M., et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999, 402:672-676.
23. Maiuri M.C., Le Toumelin G., Criollo A., et al. Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J. 2007, 26:2527-2539.
24. Matros E., Wang Z.C., Lodeiro G., Miron A., Iglehart J.D., Richardson A.L. BRCA1 promoter methylation in sporadic breast tumors: relationship to gene expression profiles. Breast Cancer Res. Treat. 2005, 91:179-186.
25. Mermel C.H., Schumacher S.E., Hill B., Meyerson M.L., Beroukhim R., Getz G. GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers. Genome Biol. 2011, 12:R41.
26. Mo N., Lu Y.K., Xie W.M., et al. Inhibition of autophagy enhances the radiosensitivity of nasopharyngeal carcinoma by reducing Rad51 expression. Oncol. Rep. 2014, 32:1905-1912.
27. Mueller C.R., Roskelley C.D. Regulation of BRCA1 expression and its relationship to sporadic breast cancer. Breast Cancer Res. 2003, 5:45-52.
28. Negri T., Tarantino E., Orsenigo M., et al. Chromosome band 17q21 in breast cancer: significant association between beclin 1 loss and HER2/NEU amplification. Genes Chromosomes Cancer 2010, 49:901-909.
29. Palacios J., Robles-Frias M.J., Castilla M.A., Lopez-Garcia M.A., Benitez J. The molecular pathology of hereditary breast cancer. Pathobiology 2008, 75:85-94.
30. Parker J.S., Mullins M., Cheang M.C., et al. Supervised risk predictor of breast cancer based on intrinsic subtypes. J. Clin. Oncol. 2009, 27:1160-1167.
31. Pattingre S., Tassa A., Qu X., et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005, 122:927-939.
32. Perou C.M., Sorlie T., Eisen M.B., et al. Molecular portraits of human breast tumours. Nature 2000, 406:747-752.
33. Qu X., Yu J., Bhagat G., et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Invest. 2003, 112:1809-1820.
34. Rakha E.A., Reis-Filho J.S., Ellis I.O. Basal-like breast cancer: a critical review. J. Clin. Oncol. 2008, 26:2568-2581.
35. Rakha E.A., El-Sheikh S.E., Kandil M.A., El-Sayed M.E., Green A.R., Ellis I.O. Expression of BRCA1 protein in breast cancer and its prognostic significance. Hum. Pathol. 2008, 39:857-865.
36. Richardson A.L., Wang Z.C., De Nicolo A., et al. X chromosomal abnormalities in basal-like human breast cancer. Cancer Cell 2006, 9:121-132.
37. Shedden K., Taylor J.M., Enkemann S.A., et al. Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study. Nat. Med. 2008, 14:822-827.
38. Sorlie T., Perou C.M., Tibshirani R., et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. U. S. A. 2001, 98:10869-10874.
39. Sotiriou C., Pusztai L. Gene-expression signatures in breast cancer. N. Engl. J. Med. 2009, 360:790-800.
40. Staff S., Isola J., Tanner M. Haplo-insufficiency of BRCA1 in sporadic breast cancer. Cancer Res. 2003, 63:4978-4983.
41. Turner N.C., Reis-Filho J.S. Basal-like breast cancer and the BRCA1 phenotype. Oncogene 2006, 25:5846-5853.
42. Turner N., Tutt A., Ashworth A. Hallmarks of 'BRCAness' in sporadic cancers. Nat. Rev. Cancer 2004, 4:814-819.
43. Turner N.C., Reis-Filho J.S., Russell A.M., et al. BRCA1 dysfunction in sporadic basal-like breast cancer. Oncogene 2007, 26:2126-2132.
44. Valentin M.D., da Silva S.D., Privat M., Alaoui-Jamali M., Bignon Y.J. Molecular insights on basal-like breast cancer. Breast Cancer Res. Treat. 2012, 134:21-30.
45. Wang R.C., Wei Y., An Z., et al. Akt-mediated regulation of autophagy and tumorigenesis through beclin 1 phosphorylation. Science 2012, 338:956-959.
46. Wei Y., Zou Z., Becker N., et al. EGFR-mediated beclin 1 phosphorylation in autophagy suppression, tumor progression, and tumor chemoresistance. Cell 2013, 154:1269-1284.
47. Wu Z.Q., Li X.Y., Hu C.Y., Ford M., Kleer C.G., Weiss S.J. Canonical Wnt signaling regulates slug activity and links epithelial-mesenchymal transition with epigenetic breast cancer 1, early onset (BRCA1) repression. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:16654-16659.
48. Wu T., Li Y., Gong L., et al. Multi-step process of human breast carcinogenesis: a role for BRCA1, BECN1, CCND1, PTEN and UVRAG. Mol. Med. Rep. 2012, 5:305-312.
49. Yao Q., Chen J., Lv Y., et al. The significance of expression of autophagy-related gene beclin, Bcl-2, and Bax in breast cancer tissues. Tumour Biol. 2011, 32:1163-1171.
50. Yersal O., Barutca S. Biological subtypes of breast cancer: prognostic and therapeutic implications. World J. Clin. Oncol. 2014, 5:412-424.
51. Yue Z., Jin S., Yang C., Levine A.J., Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:15077-15082.