The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment

Aging Cell

Volumn 14, Issue 2, 2015, Pages 180-190

  Nair, Savita ^a   Fang, Min ^a,b   Sigal, Luis J ^a  

^a FOX CHASE CANCER CENTER   (United States)

^b INSTITUTE OF MICROBIOLOGY   (China)

Author keywords

Aging; Cellular immunology; Immune cell development; Immunosenescence; Mice; Natural killer cells

Indexed keywords

COLLAGEN BINDING PROTEIN; INTEGRIN; RECOMBINANT INTERLEUKIN 15; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR ALPHA; RECOMBINANT PROTEIN;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW STROMA CELL; CELL EXPANSION; CELL MATURATION; CELL PROLIFERATION; FEMALE; FITNESS; IMMATURITY; IMMUNOSENESCENCE; IN VIVO STUDY; MOUSE; MOUSEPOX; NATURAL KILLER CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SENESCENCE; AGE; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CELL DIFFERENTIATION; CYTOLOGY; DRUG EFFECTS; HUMAN; IMMUNOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; STROMA CELL;

ECTROMELIA VIRUS; MUS; RODENTIA;

AGE FACTORS; AGED; ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; FEMALE; HUMANS; INTERLEUKIN-15; INTERLEUKIN-15 RECEPTOR ALPHA SUBUNIT; KILLER CELLS, NATURAL; MICE; MICE, INBRED C57BL; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; STROMAL CELLS;

EID: 84924232977     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12291     Document Type: Article

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