A germline mutation in the miR-125a coding region reduces miR-125a expression and is associated with human gastric cancer

Molecular Medicine Reports

Volumn 10, Issue 4, 2014, Pages 1839-1844

  Shang, Hua ^a,b   Wang, Tao ^c   Shang, Feng ^d   Huang, Kun Ming ^b   Li, Yan Qing ^a  

^a SHANDONG UNIVERSITY   (China)

^b Central Hospital of Zibo   (China)

^c The Affiliated Linzi District People's Hospital of Binzhou Medical University   (China)

^d 94th Hospital of People's Liberation Army of China   (China)

Author keywords

ERBB2; Gastric cancer; microRNA; miR 125a

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ERBB2 PROTEIN, HUMAN; MICRORNA; MIRN125 MICRORNA, HUMAN;

ALLELE; CHEMISTRY; CONFORMATION; GENE FREQUENCY; GENETICS; GENOTYPE; GERMLINE MUTATION; HUMAN; METABOLISM; PATHOLOGY; STOMACH; STOMACH TUMOR; TUMOR CELL LINE;

ALLELES; CELL LINE, TUMOR; GENE FREQUENCY; GENOTYPE; GERM-LINE MUTATION; HUMANS; MICRORNAS; NUCLEIC ACID CONFORMATION; RECEPTOR, ERBB-2; STOMACH; STOMACH NEOPLASMS;

EID: 84924219723     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2014.2441     Document Type: Article

References (20)

1. Wu WK, Lee CW, Cho CH, et al: MicroRNA dysregulation in gastric cancer: a new player enters the game. Oncogene 29: 5761-5771, 2010.
2. Nicoloso MS, Spizzo R, Shimizu M, Rossi S and Calin GA: MicroRNAs - the micro steering wheel of tumour metastases. Nat Rev Cancer 9: 293-302, 2009.
3. Li W, Duan R, Kooy F, Sherman SL, Zhou W and Jin P: Germline mutation of microRNA-125a is associated with breast cancer. J Med Genet 46: 358-360, 2009.
4. Guo X, Wu Y and Hartley RS: MicroRNA-125a represses cell growth by targeting HuR in breast cancer. RNA Biol 6: 575-583, 2009.
5. Wang G, Mao W, Zheng S and Ye J: Epidermal growth factor receptor-regulated miR-125a-5p - a metastatic inhibitor of lung cancer. FEBS J 276: 5571-5578, 2009.
6. Jiang L, Huang Q, Zhang S, et al: Hsa-miR-125a-3p and hsa-miR-125a-5p are downregulated in non-small cell lung cancer and have inverse effects on invasion and migration of lung cancer cells. BMC Cancer 10: 318, 2010.
7. Cowden Dahl KD, Dahl R, Kruichak JN and Hudson LG: The epidermal growth factor receptor responsive miR-125a represses mesenchymal morphology in ovarian cancer cells. Neoplasia 11: 1208-1215, 2009.
8. Cortez MA, Nicoloso MS, Shimizu M, et al: miR-29b and miR-125a regulate podoplanin and suppress invasion in glioblastoma. Genes Chromosomes Cancer 49: 981-990, 2010.
9. Nishida N, Mimori K, Fabbri M, et al: MicroRNA-125a-5p is an independent prognostic factor in gastric cancer and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab. Clin Cancer Res 17: 2725-2733, 2011.
10. Hashiguchi Y, Nishida N, Mimori K, et al: Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathological significance. Int J Oncol 40: 1477-1482, 2012.
11. Duan R, Pak C and Jin P: Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA. Hum Mol Genet 16: 1124-1131, 2007. (Pubitemid 47062732)
12. Scott GK, Goga A, Bhaumik D, Berger CE, Sullivan CS and Benz CC: Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b. J Biol Chem 282: 1479-1486, 2007. (Pubitemid 47076526)
13. Wang S, Huang J, Lyu H, et al: Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2/erbB3 and apoptosis in breast cancer cells. Cell Death Dis 4: e556, 2013.
14. Schade B, Lesurf R, Sanguin-Gendreau V, et al: β-Catenin signaling is a critical event in ErbB2-mediated mammary tumor progression. Cancer Res 73: 4474-4487, 2013.
15. Conesa-Zamora P, Torres-Moreno D, Isaac MA and Pérez-Guillermo M: Gene amplification and immunohistochemical expression of ERBB2 and EGFR in cervical carcinogenesis. Correlation with cell-cycle markers and HPV presence. Exp Mol Pathol 95: 151-155, 2013.
16. Di Leva G, Garofalo M and Croce CM: MicroRNAs in cancer. Annu Rev Pathol 9: 287-314, 2014.
17. Gargalionis AN and Basdra EK: Insights in microRNAs biology. Curr Top Med Chem 13: 1493-1502, 2013.
18. Hu Y, Liu CM, Qi L, et al: Two common SNPs in pri-miR-125a alter the mature miRNA expression and associate with recurrent pregnancy loss in a Han-Chinese population. RNA Biol 8: 861-872, 2011.
19. Jazdzewski K, Murray EL, Franssila K, Jarzab B, Schoenberg DR and de la Chapelle A: Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc Natl Acad Sci USA 105: 7269-7274, 2008. (Pubitemid 351754467)
20. Saunders MA, Liang H and Li WH: Human polymorphism at microRNAs and microRNA target sites. Proc Natl Acad Sci USA 104: 3300-3305, 2007. (Pubitemid 46364154)