Poly (D,L-Lactide-co-Glycolide) nanoparticles loaded with cerebrolysin display neuroprotective activity in a rat model of concussive head injury

CNS and Neurological Disorders - Drug Targets

Volumn 13, Issue 8, 2014, Pages 1475-1482

  Ruozi, Barbara ^a   Belletti, Daniela ^a   Forni, Flavio ^a   Sharma, Aruna ^b   Muresanu, Dafin ^c   Mössler, Herbert ^d   Vandelli, Maria A ^a   Tosi, Giovanni ^a   Sharma, Hari S ^b  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^c GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^d EVER Neuro Pharma   (Austria)

Author keywords

Blood brain barrier; Brain edema; Cerebrolysin; Closed head injury; Poly (D,L lactide co glycolide) nanoparticles

Indexed keywords

CEREBROLYSIN; NANOPARTICLE; POLYGLACTIN; LACTIC ACID; NEUROPROTECTIVE AGENT; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN EDEMA; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG FORMULATION; DRUG STABILITY; DRUG TARGETING; ENZYMATIC DEGRADATION; FREEZE DRYING; HEAD INJURY; NEUROPROTECTION; NONHUMAN; PARTICLE SIZE; PERMEABILITY; RAT; SCANNING ELECTRON MICROSCOPY; SPECTROPHOTOMETRY; ZETA POTENTIAL; ANALYSIS OF VARIANCE; ANIMAL; BRAIN CONCUSSION; COMPLICATION; DISEASE MODEL; TIME; ULTRASTRUCTURE;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN CONCUSSION; BRAIN EDEMA; DISEASE MODELS, ANIMAL; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; NEUROPROTECTIVE AGENTS; POLYGLYCOLIC ACID; RATS; TIME FACTORS;

EID: 84924200187     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/1871527313666140806145540     Document Type: Article

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