Antibodies to dynorphin A (1-17) attenuate closed head injury induced blood-brain barrier disruption, brain edema formation and brain pathology in the rat

Acta Neurochirurgica, Supplementum

Volumn , Issue 106, 2009, Pages 301-306

  Sharma, H S ^a   Patnaik, R ^b   Patnaik, S ^b   Sharma, A ^a   Mohanty, S ^c   Vannemreddy, P ^a,d  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b BANARAS HINDU UNIVERSITY   (India)

^c BANARAS HINDU UNIVERSITY   (India)

^d Louisiana State University School of Medicine Shreveport   (United States)

Author keywords

blood brain barrier; brain edema; brain pathology; Closed head injury; dynorphin A antiserum

Indexed keywords

DYNORPHIN A; DYNORPHIN A ANTIBODY; DYNORPHIN ANTIBODY; EVANS BLUE; MONOCLONAL ANTIBODY; RADIOACTIVE IODINE; UNCLASSIFIED DRUG;

ANESTHESIA; BLOOD BRAIN BARRIER; BLOOD BRAIN BARRIER DYSFUNCTION; BRAIN CONCUSSION; BRAIN DISEASE; BRAIN DYSFUNCTION; BRAIN EDEMA; BRAIN VENTRICLE; CEREBROSPINAL FLUID; CONFERENCE PAPER; DRUG EFFICACY; EARLY INTERVENTION; HEAD INJURY; HEMISPHERE; HISTOPATHOLOGY; MALE; NEUROPROTECTION; NONHUMAN; RAT; SKULL;

EID: 78649367181     PISSN: 00651419     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-211-98811-4_56     Document Type: Conference Paper

References (14)

1. Bakshi R, Ni RX, Faden AI (1992) N-methyl-d-aspartate (NMDA) and opioid receptors mediate dynorphin-induced spinal cord injury: behavioral and histological studies. Brain Res May 15; 580(1-2): 255-264
2. Dey PK, Sharma HS (1984) Influence of ambient temperature and drug treatments on brain oedema induced by impact injury on skull in rats. Indian J Physiol Pharmacol Jul-Sep; 28(3):177-186
3. Faden AI (1990) Opioid and nonopioid mechanisms may contribute to dynorphin's pathophysiological actions in spinal cord injury. Ann Neurol Jan; 27(1):67-74
4. Faden AI (1992) Dynorphin increases extracellular levels of excitatory amino acids in the brain through a non-opioid mechanism. J Neurosci Feb; 12(2):425-429
5. Reddy CC, Collins MW, Gioia GA (2008) Adolescent sports concussion. Phys Med Rehabil Clin N Am May; 19(2):247-69, viii. Review
6. Sharma HS, Alm P (2002) Nitric oxide synthase inhibitors influence dynorphin A (1-17) immunoreactivity in the rat brain following hyperthermia. Amino Acids 23(1-3):247-259
7. Sharma HS, Nyberg F, Gordh T, Alm P (2006) Topical application of dynorphin A (1-17) antibodies attenuates neuronal nitric oxide synthase up-regulation, edema formation, and cell injury following focal trauma to the rat spinal cord. Acta Neurochir Suppl 96: 309-315
8. Sharma HS, Patnaik R, Patnaik S, Mohanty S, Sharma A, Vannemreddy P (2007) Antibodies to serotonin attenuate closed head injury induced blood brain barrier disruption and brain pathology. Ann N Y Acad Sci Dec; 1122:295-312
9. Sharma HS, Nyberg F, Olsson Y (1992) Dynorphin A content in the rat brain and spinal cord after a localized trauma to the spinal cord and its modification with p-chlorophenylalanine. An experimental study using radioimmunoassay technique. Neurosci Res Aug; 14(3):195-203
10. Sharma HS, Olsson Y, Nyberg F (1995) Influence of dynorphin A antibodies on the formation of edema and cell changes in spinal cord trauma. Prog Brain Res 104:401-416. Review
11. Sharma HS, Olsson Y, Dey PK (1990) Changes in blood-brain barrier and cerebral blood flow following elevation of circulating serotonin level in anesthetized rats. Brain Res May 28; 517(1-2): 215-223
12. Vannemreddy P, Ray AK, Patnaik R, Patnaik S, Mohanty S, Sharma HS (2006) Zinc protoporphyrin IX attenuates closed head injuryinduced edema formation, blood-brain barrier disruption, and serotonin levels in the rat. Acta Neurochir Suppl 96:151-156
13. Winkler T, Sharma HS, Gordh T, Badgaiyan RD, Stålberg E, Westman J (2002) Topical application of dynorphin A (1-17) antiserum attenuates trauma induced alterations in spinal cord evoked potentials, microvascular permeability disturbances, edema formation and cell injury: an experimental study in the rat using electrophysiological and morphological approaches. Amino Acids 23(1-3):273-281
14. Xydakis MS, Robbins AS, Grant GA (2008) Mild traumatic brain injury in U.S. soldiers returning from Iraq. N Engl J Med May 15; 358(20):2177; author reply 2179