Hyperreactivity of junctional adhesion molecule A-deficient platelets accelerates atherosclerosis in hyperlipidemic mice

Circulation Research

Volumn 116, Issue 4, 2015, Pages 587-599

  Karshovska, Ela ^a   Zhao, Zhen ^a,b   Blanchet, Xavier ^a   Schmitt, Martin M N ^a   Bidzhekov, Kiril ^a   Soehnlein, Oliver ^a,c,d   Von Hundelshausen, Philipp ^a,d   Mattheij, Nadine J ^e   Cosemans, Judith M E M ^e   Megens, Remco T A ^a,e   Koeppel, Thomas A ^b   Schober, Andreas ^a,d   Hackeng, Tilman M ^e   Weber, Christian ^a,d,e   Koenen, Rory R ^a,e  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

^e MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Atherosclerosis; Blood platelets; Cell adhesion molecules; Inflammation; Phosphoprotein phosphatases

Indexed keywords

APOLIPOPROTEIN E; CHEMOKINE RECEPTOR CXCR4; JUNCTIONAL ADHESION MOLECULE A; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; RANTES; VERY LATE ACTIVATION ANTIGEN 3; AUTACOID; CELL ADHESION MOLECULE; CELL SURFACE RECEPTOR; F11R PROTEIN, MOUSE; FIBRINOGEN RECEPTOR; PROTEIN TYROSINE PHOSPHATASE 1B;

ANIMAL CELL; ANIMAL EXPERIMENT; AORTA ATHEROSCLEROSIS; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; ENDOTHELIUM; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MALE; MICROSCOPY; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEPHOSPHORYLATION; SMOOTH MUSCLE FIBER; T LYMPHOCYTE; THROMBOCYTE; THROMBOCYTE AGGREGATION; ANIMAL; AORTA; AORTIC DISEASES; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD; C57BL MOUSE; CAROTID ARTERY DISEASES; CELL ADHESION; CELL CULTURE; COMPLICATION; DEFICIENCY; DISEASE COURSE; DISEASE MODEL; GENETICS; GENOTYPE; KNOCKOUT MOUSE; LEUKOCYTE; LIPID DIET; METABOLISM; NEUTROPHIL CHEMOTAXIS; PATHOLOGY; PHENOTYPE; THROMBOSIS; TIME;

ANIMALS; AORTA; AORTIC DISEASES; APOLIPOPROTEINS E; ATHEROSCLEROSIS; BLOOD PLATELETS; CAROTID ARTERY DISEASES; CELL ADHESION; CELL ADHESION MOLECULES; CELLS, CULTURED; CHEMOTAXIS, LEUKOCYTE; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; GENOTYPE; HUMANS; HYPERLIPIDEMIAS; INFLAMMATION MEDIATORS; LEUKOCYTES; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; PLAQUE, ATHEROSCLEROTIC; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; RECEPTORS, CELL SURFACE; SRC-FAMILY KINASES; THROMBOSIS; TIME FACTORS;

EID: 84924176426     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.116.304035     Document Type: Article

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