Glycyrrhizin ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c Mice and inhibits TNF-α-Induced ICAM-1 Expression via NF-κB/MAPK in HaCaT Cells

Cellular Physiology and Biochemistry

Volumn 35, Issue 4, 2015, Pages 1335-1346

  Xiong, Hui ^a   Xu, Ying ^a   Tan, Guozhen ^a   Han, Yanfang ^a   Tang, Zengqi ^a   Xu, Wenying ^b   Zeng, Fanqin ^a   Guo, Qing ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b PEOPLE'S HOSPITAL OF GUANGXI ZHUANG AUTONOMOUS REGION   (China)

Author keywords

Glycyrrhizin; ICAM 1; Imiquimod; Inflammation; Keratinocytes; MAPKs; NF B; Psoriasis

Indexed keywords

CARBOXYFLUORESCEIN DIACETATE SUCCINIMIDYL ESTER; GLYCYRRHIZIC ACID; IMIQUIMOD; INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; AMINOQUINOLINE DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BAGG ALBINO MOUSE; CELL ADHESION; CELL COUNTING; CELL PROLIFERATION; CELL VIABILITY; CHEMICAL LABELING; CONTROLLED STUDY; DISEASE SEVERITY; DRUG CYTOTOXICITY; DRUG MECHANISM; EXPERIMENTAL DERMATITIS; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; KERATINOCYTE; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PSORIASIS; PSORIASIS AREA AND SEVERITY INDEX; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMICALLY INDUCED; CYTOLOGY; DRUG EFFECTS; IMMUNOLOGY; INFLAMMATION; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SKIN DISEASES; UPREGULATION;

ANIMALIA; MUS;

AMINOQUINOLINES; ANIMALS; CELL ADHESION; CELL LINE; CELL SURVIVAL; FEMALE; GLYCYRRHIZIC ACID; HUMANS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; NF-KAPPA B; PHOSPHORYLATION; PSORIASIS; SIGNAL TRANSDUCTION; SKIN DISEASES; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 84924161912     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000373955     Document Type: Article

References (34)

1. Nestle FO, Kaplan DH, Barker J: Psoriasis. N Engl J Med 2009;361:13.
2. Wagner EF, Schonthaler HB, Guinea-Viniegra J, Tschachler E: Psoriasis: What we have learned from mouse models. Nat Rev Rheumatol 2010;6:704-714.
3. Dustin ML, Singer KH, Tuck DT, Springer TA: Adhesion of t lymphoblasts to epidermal keratinocytes is regulated by interferon gamma and is mediated by intercellular adhesion molecule 1 (ICAM-1). J Exp Med 1988;167:1323-1340.
4. Roebuck KA, Finnegan A: Regulation of intercellular adhesion molecule-1 (CD54) gene expression. J Leukoc Biol 1999;66:876-888.
5. Ohtsuki K, Oh-Ishi M, Nagata N: The stimulatory and inhibitory effects of glycyrrhizin and a glycyrrhetinic acid derivative on phosphorylation of lipocortin I by A-kinase in vitro Biochem Int 1992;28:1045-1053.
6. Sur I, Ulvmar M, Toftgård R: The two-faced NF-kappaB in the skin. Int Rev Immunol2008;27:205-223.
7. Revers FE: Heeft succus liquiritiae een genezende werking op de maagzweer? Ned Tijdschr Geneesk 1946;90:135-137
8. Fujisawa K, Tandon BN: Therapeutic approach to the chronic active liver disease: Summary of a satellite symposium; in Nishioka K, Suzuki H, Mishiro S, Oda T (eds): Viral Hepatitis and Liver Disease. Tokyo, Springer, 1994, pp 662-665.
9. Shibata S: A drug over the millennia: Pharmacognosy, chemistry, and pharmacology of licorice. Yakugaku Zasshi 2000;120:849-862.
10. Cinatl J, Morgenstern B, Bauer G, Chandra P, Rabenau H, Doerr H: Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus. Lancet 2003;361:2045-2046.
11. Haraguchi H, Yoshida N, Ishikawa H, Tamura Y, Mizutani K, Kinoshita T: Protection of mitochondrial functions against oxidative stresses by isoflavans from glycyrrhiza glabra. J Pharm Pharmacol 2000;52:219-223.
12. Di Mambro VM, Fonseca MJ: Assays of physical stability and antioxidant activity of a topical formulation added with different plant extracts. J Pharm Biomed Anal 2005;37:287-295.
13. Kobayashi S, Miyamoto T, Kimura I, Kimura M: Inhibitory effect of isoliquiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro. Biol Pharm Bull 1995;18:1382-1386.
14. Feng L, Zhu M-M, Zhang M-H, Wang R-S, Tan X-B, Song J, Ding S-M, Jia X-B, Hu S-Y: Protection of glycyrrhizic acid against ages-induced endothelial dysfunction through inhibiting RAGE/NF-κB pathway activation in human umbilical vein endothelial cells. J Ethnopharmacol 2013;148:27-36.
15. Trefzer U, Brockhaus M, Loetscher H, Parlow F, Kapp A, Schöpf E, Krutmann J: 55-kd tumor necrosis factor receptor is expressed by human keratinocytes and plays a pivotal role in regulation of human keratinocyte ICAM-1 expression. J Invest Dermatol 1991;97:911-916.
16. Krutmann J, Czech W, Parlow F, Trefzer U, Kapp A, Schöpf E, Luger TA: Ultraviolet radiation effects on human keratinocyte icam-1 expression: UV-induced inhibition of cytokine-induced ICAM-1 mrna expression is transient, differentially restored for IFNγ versus TNF-α and followed by ICAM-1 induction via a TNF-α like pathway. J Invest Dermatol 1992;98:923-928.
17. Gottlieb A, Krueger JG, Bright R, Ling M, Lebwohl M, Kang S, Feldman S, Spellman M, Wittkowski K, Ochs HD: Effects of administration of a single dose of a humanized monoclonal antibody to CD11a on the immunobiology and clinical activity of psoriasis. J Am Acad Dermatol 2000;42:428-435.
18. Andrés RM, Montesinos MC, Navalón P, Payá M, Terencio MC: Nf-κb and stat3 inhibition as a therapeutic strategy in psoriasis: In vitro and in vivo effects of bth. J Invest Dermatol 2013;133:2362-2371.
19. Thommesen L, Sjursen W, Gåsvik K, Hanssen W, Brekke O-L, Skattebøl L, Holmeide AK, Espevik T, Johansen B, Lægreid A: Selective inhibitors of cytosolic or secretory phospholipase A2 block TNF-induced activation of transcription factor nuclear factor-κb and expression of ICAM-1. J Immunol 1998;161:3421-3430.
20. Jae We Cho K-SL, Change-Wook Kim: Curcumin attenuates the expression of IL-1β, IL-6, and TNF-α as well as cyclin E in TNF-α-treated hacat cells: NF-κB and MAPKS as potential upstream targets. Int J Mol Med 2007;19:469-74
21. Van der Fits L, Mourits S, Voerman JS, Kant M, Boon L, Laman JD, Cornelissen F, Mus A-M, Florencia E, Prens EP: Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol 2009;182:5836-5845.
22. Fu Y, Zhou E, Wei Z, Liang D, Wang W, Wang T, Guo M, Zhang N, Yang Z: Glycyrrhizin inhibits the inflammatory response in mouse mammary epithelial cells and a mouse mastitis model. FEBS J 2014;281:2543-2557
23. Fu Y, Zhou E, Wei Z, Song X, Liu Z, Wang T, Wang W, Zhang N, Liu G, Yang Z: Glycyrrhizin inhibits lipopolysaccharide-induced inflammatory response by reducing TLR4 recruitment into lipid rafts in RAW264. 7 cells. Biochim Biophys Acta 2014;1840:1755-1764.
24. Bowcock AM, Krueger JG: Getting under the skin: The immunogenetics of psoriasis. Nat Rev Immunol 2005;5:699-711.
25. Nair RP, Duffin KC, Helms C, Ding J, Stuart PE, Goldgar D, Gudjonsson JE, Li Y, Tejasvi T, Feng B-J: Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet 2009;41:199-204.
26. Goldminz A, Au S, Kim N, Gottlieb A, Lizzul P: NF-κB: an essential transcription factor in psoriasis. J Dermatol Sci 2013;69:89-94.
27. Lowes MA, Suárez-Fariñas M, Krueger JG: Immunology of psoriasis. Annu Rev Immunol 2014;32:227-255.
28. Tsuruta D: NF-κB links keratinocytes and lymphocytes in the pathogenesis of psoriasis. Recent Pat Inflamm Allergy Drug Discov 2009;3:40-48.
29. Young CN, Koepke JI, Terlecky LJ, Borkin MS, Boyd SL, Terlecky SR: Reactive oxygen species in tumor necrosis factor-alpha-activated primary human keratinocytes: Implications for psoriasis and inflammatory skin disease. J Invest Dermatol 2008;128:2606-2614.
30. Bahar-Shany K, Ravid A, Koren R: Upregulation of MMP-9 production by TNFalpha in keratinocytes and its attenuation by vitamin D. J Cell Physiol 2010;222:729-737.
31. Kwon D-J, Bae Y-S, Ju SM, Goh AR, Choi SY, Park J: Casuarinin suppresses TNF-α-induced ICAM-1 expression via blockade of NF-κB activation in hacat cells. Biochem Biophys Res Commun 2011;409:780-785.
32. Walter A, Schäfer M, Cecconi V, Matter C, Urosevic-Maiwald M, Belloni B, Schönewolf N, Dummer R, Bloch W, Werner S: Aldara activates TLR7-independent immune defence. Nat Commun 2013;4:1560.
33. Flutter B, Nestle FO: TLRs to cytokines: Mechanistic insights from the imiquimod mouse model of psoriasis. Eur J Immunol 2013;43:3138-3146.
34. Cai Y, Shen X, Ding C, Qi C, Li K, Li X, Jala VR, Zhang H-g, Wang T, Zheng J: Pivotal role of dermal IL-17-producing γδ t cells in skin inflammation. Immunity 2011;35:596-610.