A novel inhibitor of Plasmodium falciparum spermidine synthase: A twist in the tail

Malaria Journal

Volumn 14, Issue 1, 2015, Pages

  Burger, Pieter B ^a   Williams, Marni ^a   Sprenger, Janina ^b   Reeksting, Shaun B ^a   Botha, Mariëtte ^a   Müller, Ingrid B ^c,d   Joubert, Fourie ^a   Birkholtz, Lyn Marie ^a   Louw, Abraham I ^a  

^a UNIVERSITY OF PRETORIA   (South Africa)

^b LUND UNIVERSITY   (Sweden)

^c BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^d Patent Department   (Switzerland)

Author keywords

Crystal structures; Pharmacophores; Plasmodium falciparum; Spermidine; Spermidine synthase; Spermine; Virtual screening

Indexed keywords

(1,4 ) (N1 (3 AMINOPROPYL)TRANS CYCLOHEXANE 1,4 DIAMINE; ANTIMALARIAL AGENT; N (3 AMINOPROPYL)CYCLOHEXYLAMINE; OCTANE; PLASMODIUM FALCIPARUM SPERMIDINE SYNTHASE; PUTRESCINE; S ADENOSYL 1,8 DIAMINO 3 THIO OCTANE; S ADENOSYLMETHIONINE; SPERMIDINE DERIVATIVE; SPERMIDINE SYNTHASE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; PROTEIN BINDING;

ANTIMALARIAL ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DECARBOXYLATION; ENTROPY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBSTRATE; IC50; LIGAND BINDING; NONHUMAN; PHARMACOPHORE; PLASMODIUM FALCIPARUM; PREDICTION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; ENZYMOLOGY; ISOLATION AND PURIFICATION; MOLECULAR DYNAMICS;

ANTIMALARIALS; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MOLECULAR DYNAMICS SIMULATION; PLASMODIUM FALCIPARUM; PROTEIN BINDING; SPERMIDINE SYNTHASE;

EID: 84924160211     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/s12936-015-0572-z     Document Type: Article

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