Pathogenesis of acute pancreatitis

Digestion

Volumn 58, Issue , 1997, Pages 46-49

  Steer, Michael L ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Acute; Caerulein; Cholecystokinin; Pancreatitis; Proenzymes; Zymogens

Indexed keywords

CERULETIDE; CHOLECYSTOKININ; ENZYME; ENZYME PRECURSOR; ZYMOGEN GRANULE;

ACINAR CELL; ACUTE PANCREATITIS; APOPTOSIS; CELL DEATH; CONFERENCE PAPER; CYTOLOGY; DISEASE SEVERITY; ENZYME ACTIVATION; PANCREAS NECROSIS; PATHOGENESIS; PRIORITY JOURNAL;

ACUTE DISEASE; ANIMALS; APOPTOSIS; CHOLECYSTOKININ; CYTOPLASMIC GRANULES; ENZYME ACTIVATION; ENZYME PRECURSORS; ENZYMES; HUMANS; NECROSIS; PANCREATITIS;

EID: 0030983174     PISSN: 00122823     EISSN: 14219867     Source Type: Journal    
DOI: 10.1159/000201525     Document Type: Article

References (16)

1. Lombardi B, Estes IW, Longnecker DW: Acute hemorrhagic pancreatitis (massive necrosis) w ilh fat necrosis induced in mice by DL-ethionine fed with a choline-deficient diet. Am. J Pathol 1975;79:465-480.
2. Lampel M, Kern H: Acute interstitial pancreatitis in the rat induced by excessive doses of a pancreatic sccretagogue. Virchows Arch 1977; 373:97-117.
3. Niederau C, Liddle RA, Ferrell LD, Grandell JH: Beneficial effects of cholecystokinin-recep-tor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis. J Clin Invest 1986:78: 1056-1063.
4. Oshio G, Saluja A, Steer ML: Effects of shortterm pancreatic duct obstruction in rats. Gastroenterology 1991:100:196-202.
5. Steer ML, Meldolesi J: The cell biology of experimental pancreatitis. N Engl J Med 1987: 316:144-150.
6. Steer ML, Saluja AK: Experimental acute pancreatitis: Studies of the early events that lead to cell injury; in Go VLW. Dimagno G. Gardner G et al. (eds): The pancreas: Biology. Pathophysiology and Disease, ed 2. New York. Raven Press. 1993. pp 489-499.
7. Greenbaum LA, Hirschkowitz A: Endogenous cathepsin activates irvpsinogen in extracts of dog pancreas. Proc Soc Exp Biol Med 1961:107: 74-76.
8. Figarella C, Miszczuk-Jamska B, Barrett AJ: Possible lysosomal activation of pancreatic zymogens: Activation of both human trypsinog-ens by cathepsin B and spontaneous acid activation ol'human trypsinogen 1. Biol Chem Hoppe Seyler 1988:369:293-298.
9. Grady T, Saluja A, Kaiser A, Steer M: Pancreatic edema and intrapancreatic activation of trypsinogen during secretagoguc-induced pancreatitis precedes glutathione depletion. Ant J Physiol 1996, in press.
10. Saluja AK, Donovan EA, Yamanaka K, Yantaguchi Y, Hofbrauer B, Steer MI: Caerulein-induced in vitro activation of trypsinogen in rat pancreatic acini: Role of cathepsin B. 1996. submitted for publication.
11. Kaiser AM, Saluja AK, Sengupta A, Saluja M, Steer ML: Relationship between severity, necrosis and apoptosis in five models of experimental acute pancreatitis. Am J Physiol 1995: 269:C1295-C1304.
12. Kaiser AM, Saluja AK, Lu L, Yamanaka K, Yamaguchi Y, Steer ML: Effects of cyclohexa-mide on pancreatic endonuclease activity, acinar cell apoptosis. and the severity of acute pancreatitis. Am J Physiol 1996. in press.
13. Folsch UR, Wormslev KG: The pancreatic secretion of enzymes in rats treated with soybean diet. Scand J Gastroenterol 1974:9:679-683.
14. Oates PS, Reginald G, Morgan H, Light AM: Cell death (apoptosis) during pancreatic involution after raw soya flour feeding in the rat. Am J Physiol 1986:250:C9-G14.
15. Saluja A, Hofbauer B, Yamaguchi Y, Yamanaka K, Steer M: Induction of apoptosis reduces the severity of caerulein-indueed pancreatitis in mice. Biochem Biophys Res Commun 1996:220: 875-878.
16. Steer ML: Recent insights into thie etiology and pathogenesis of acute biliary pancreatitis. Am J Roentgenol 1995:164:811-814.