Plasmodium falciparum susceptibility to standard and potential anti-malarial drugs in Dakar, Senegal, during the 2013-2014 malaria season

Malaria Journal

Volumn 14, Issue 1, 2015, Pages

  Fall, Bécaye ^a   Camara, Cheikhou ^a   Fall, Mansour ^a   Nakoulima, Aminata ^a   Dionne, Pierre ^a   Diatta, Bakary ^a   Diemé, Yaya ^a   Wade, Boubacar ^a   Pradines, Bruno ^a,b,c,d  

^a HÔPITAL PRINCIPAL DE DAKAR   (Senegal)

^b INSTITUT DE RECHERCHE BIOMÉDICALE DES ARMÉES   (France)

^c AIX MARSEILLE UNIVERSITÉ   (France)

^d Centre National de Reference du Paludisme   (France)

Author keywords

Anti malarial; In vitro; Malaria; Methylene blue; Plasmodium falciparum; Proveblue; Resistance; Senegal

Indexed keywords

AMODIAQUINE; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; ARTESUNATE; BENFLUMETOL; CHLOROQUINE; DEETHYLAMODIAQUINE; DIHYDROARTEMISININ; MEFLOQUINE; METHYLENE BLUE; PIPERAQUINE; PYRONARIDINE; QUININE;

ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; CLINICAL ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; FEMALE; HUMAN; IC50; IN VITRO STUDY; MALARIA FALCIPARUM; MALE; PREVALENCE; SENEGAL; DRUG EFFECTS; DRUG RESISTANCE; MALARIA, FALCIPARUM; PARASITOLOGY; PLASMODIUM FALCIPARUM;

ANTIMALARIALS; DRUG RESISTANCE; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MALARIA, FALCIPARUM; MALE; PLASMODIUM FALCIPARUM; PREVALENCE; SENEGAL;

EID: 84924100840     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/s12936-015-0589-3     Document Type: Article

References (58)

1. Ndiaye JLA, Faye B, Gueye A, Tine R, Ndiaye D, Tchania C, et al. Repeated treatment of recurrent uncomplicated Plasmodium falciparum malaria in Senegal with fixed-dose artesunate plus amodiaquine versus fixed-dose artemether plus lumefantrine: a randomized, open-label trial. Malar J. 2011;10:237.
2. Thiam S, Thior M, Faye B, Diouf ML, Diouf MB, Diallo I, et al. Major reduction in anti-malarial drug consumption in Senegal after nation-wide introduction of malaria rapid diagnostic tests. PLoS One. 2011;6:18419.
3. Fall B, Pascual A, Sarr FD, Wurtz N, Richard V, Baret E, et al. Plasmodium falciparum susceptibility to anti-malarial drugs in Dakar, Senegal: an ex vivo and drug resistance molecular markers study. Malar J. 2013;12:107.
4. Van Tyne D, Dieye B, Valim C, Daniels RF, Diogoye Sène P, Lukens AK, et al. Changes in drug sensitivity and anti-malarial drug resistance mutations over time among Plasmodium falciparum parasites in Senegal. Malar J. 2013;12:441.
5. Lambros C, Vanderberg JP. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol. 1979;65:418-20.
6. Bogreau H, Renaud F, Bouchiba H, Durand P, Assi SB, Henry MC, et al. Genetic diversity and structure of African Plasmodium falciparum populations in urban and rural areas. Am J Trop Med Hyg. 2006;74:953-9.
7. Henry M, Diallo I, Bordes J, Ka S, Pradines B, Diatta B, et al. Urban malaria in Dakar, Senegal: chemosusceptibility and genetic diversity of Plasmodium falciparum isolates. Am J Trop Med Hyg. 2006;75:146-51.
8. ® for the evaluation of in vitro Plasmodium falciparum susceptibility to standard antimalarial drugs. Malar J. 2011;10:8.
9. Le Nagard H, Vincent C, Mentré F, Le Bras J. Online analysis of in vitro resistance to antimalarial drugs through nonlinear regression. Comput Methods Programs Biomed. 2011;104:10-8.
10. Fall B, Diawara S, Sow K, Baret E, Diatta B, Fall KB, et al. Ex vivo susceptibility of Plasmodium isolates from Dakar, Senegal, to seven standard anti-malarial drugs. Malar J. 2011;10:310.
11. Drame PM, Machault V, Diallo A, Cornélie S, Poinsignon A, Lalou R, et al. IgG responses to the gSG6-P1 salivary peptide for evaluating human exposure to Anopheles bites in urban areas of Dakar. Senegal Malar J. 2012;11:72.
12. Trape JF, Tall A, Sokhna C, Badara Ly A, Diagne N, Ndiath O, et al. The rise and fall of malaria in a west African rural community, Dielmo, Senegal, from 1990 to 2012: a 22 year longitudinal study. Lancet Infect Dis. 2014;14:476-88.
13. Jambou R, Legrand E, Niang M, Khim N, Lim P, Volney B, et al. Resistance of Plasmodium falciparum field isolates to in vitro artemether and point mutations of the SERCA-type PfATPase6. Lancet. 2005;366:1960-3.
14. Gari-Toussaint M, Pradines B, Mondain V, Keundjian A, Dellamonica P, Le Fichoux Y. Sénégal et paludisme. Echec prophylactique vrai de la méfloquine. Presse Med. 2002;31:1136.
15. Hatin I, Trape JF, Legros F, Bauchet J, Le Bras J. Susceptibility of Plasmodium falciparum strains to mefloquine in an urban area in Senegal. Bull World Health Organ. 1992;70:363-7.
16. Sokhna C, Molez JF, Ndiaye P, Sane B, Trape JF. Tests in vivo de chimiosensibilite de Plasmodium falciparum à la chloroquine au Sénégal: évolution de la résistance et estimation de l'efficacité thérapeutique. Bull Soc Pathol Exot. 1997;90:83-9.
17. Thomas SM, Ndir O, Dieng T, Mboup S, Wypij D, Maguire JH, et al. In vitro chloroquine susceptibility and PCR analysis of pfcrt and pfmdr1 polymorphisms in Plasmodium falciparum isolates from Senegal. Am J Trop Med Hyg. 2002;66:474-80.
18. Sarr O, Myrick A, Daily J, Diop BM, Dieng T, Ndir O, et al. In vivo and in vitro analysis of chloroquine resistance in Plasmodium falciparum isolates from Senegal. Parasitol Res. 2005;97:136-40.
19. Ly O, Gueye PE, Deme AB, Dieng T, Badiane AS, Ahouidi AD, et al. Evolution of the pfcrt T76 and pfmdr1 Y86 markers and chloroquine susceptibility 8 years after cessation of chloroquine use in Pikine, Senegal. Parasitol Res. 2012;111:1541-6.
20. Sarr O, Ahouidi AD, Ly O, Daily JP, Ndiaye D, Ndir O, et al. Mutations in PfCRT K76T do no correlate with sulfadoxine-pyrimethamine-amodiaquine failure in Pikine. Parasitol Res. 2008;103:765-9.
21. Gharbi M, Flegg JA, Hubert V, Kendjo E, Metcalf JE, Bertaux L, et al. Longitudinal study assessing the return of chloroquine susceptibility of Plasmodium falciparum in isolates from travellers returning from West and Central Africa, 2000-2011. Malar J. 2013;12:35.
22. Ministère de la Santé et de la Prévention Médicale. Enquête nationale sur le paludisme au Sénégal2006. 2007. http://www.measuredhs.com/pubs/pdf/MIS1/MIS1.pdf.
23. Ministère de la Santé et de la Prévention Médicale. Enquête nationale sur le paludisme au Sénégal 2008-2009. 2009. http://www.measuredhs.com/pubs/pdf/MIS5/MIS5.pdf [revised30Sep2009].
24. Noranate N, Durand R, Tall A, Marrama L, Spiegel A, Sokhna C, et al. Rapid dissemination of Plasmodium falciparum drug resistance despite strictly controlled antimalarial use. Plos One. 2007;1:139.
25. Brasseur P, Guiguemde R, Diallo S, Guiyedi V, Kombila M, Ringwald P, et al. Amodiaquine remains effective for treating ucomplicated malaria in West and Central Africa. Trans R Soc Trop Med Hyg. 1999;93:645-50.
26. Ndiaye JL, Randrianarivelojosia M, Sagara I, Brasseur P, Ndiaye I, Faye B, et al. Randomized, multicentre assessment of the efficacy and safety of ASAQ - a fixed dose artesunate-amodiaquine combination therapy in the treatment of uncomplicated Plasmodium falciparum malaria. Malar J. 2009;8:125.
27. Dondorp AM, Nosten F, Yi P, Das D, Phyo AP, Tarning J, et al. Artemisinin resistance in Plasmodium falciparum malaria. N Engl J Med. 2009;361:455-67.
28. Noedl H, Se Y, Schaecher K, Smith BL, Socheat D, Fukuda MM. Evidence of artemisinin-resistant malaria in western Cambodia. N Engl J Med. 2008;359:2619-20.
29. Phyo AP, Nkhoma S, Stepniewska K, Ashley EA, Nair S, McGready R, et al. Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet. 2012;379:1960-6.
30. Ashley EA, Dhorda M, Fairhurst RM, Amaratunga C, Lim P, Suon S, et al. Spread of artemisinin resistance in Plasmodium falciparum malaria. N Eng J Med. 2014;371:411-23.
31. Pradines B, Tall A, Rogier C, Spiegel A, Mosnier J, Marrama L, et al. In vitro activities of ferrochloroquine against 55 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs. Trop Med Int Health. 2002;7:265-70.
32. Pradines B, Mabika Mamfoumbi M, Tall A, Sokhna C, Koeck JL, Fusai T, et al. In vitro activity of tafenoquine against the asexual blood stages of Plasmodium falciparum isolates from Gabon, Senegal, and Djibouti. Antimicrob Agents Chemother. 2006;50:3225-6.
33. Ndiaye D, Patel V, Demas A, Le Roux M, Ndir O, Mboup S, et al. An nonradioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials - Increased sensitivity of P.falciparum to chloroquine in Senegal. Am J Trop Med Hyg. 2010;82:228-30.
34. Witkowski B, Amaratunga C, Khim N, Sreng S, Chim P, Kim S, et al. Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies. Lancet Infect Dis. 2013;13:1043-9.
35. Witkowski B, Khim N, Chim P, Kim S, Ke S, Kloeung N, et al. Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in Western Cambodia. Antimicrob Agents Chemother. 2013;57:914-23.
36. Ariey F, Witkowsky B, Amaratunga C, Beghain J, Langlois AC, Khim N, et al. A molecular marker of artemisinin-resistant Plasmodium falciparum. Nature. 2014;505:50-5.
37. Amaratunga C, Witkowski B, Khim N, Menard D, Fairhurst RM. Artemisinin resistance in Plasmodium falciparum. Lancet Infect Dis. 2014;14:449-50.
38. Yavo W, Faye B, Kuete T, Djohan V, Oga SA, Kassi RR, et al. Multicentric assessment of the efficacy and tolerability of dihydroartemisinin-piperaquine compared to artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa. Malar J. 2011;10:198.
39. Yeka A, Tibenderana J, Achan J, D'Alessandro U, Talisuna AO. Efficacy of quinine, artemether-lumefantrine and dihydroartemisinin-piperaquine as rescue treatment for uncomplicated malaria in Ugandan children. PLoS One. 2013;8:53772.
40. Agarwal A, McMorrow M, Onyango P, Otieno K, Odero C, Williamson J, et al. A randomized trial of artemether-lumefantrine and dihydroartemisininpiperaquine in the treatment of uncomplicated malaria among children in western Kenya. Malar J. 2013;12:254.
41. Pascual A, Madamet M, Bertaux L, Amalvict R, Benoit N, Travers D, et al. In vitro piperaquine susceptibility is not associated with the Plasmodium falciparum chloroquine resistance transporter gene. Malar J. 2013;12:431.
42. Pascual A, Parola P, Benoit-Vical F, Simon F, Malvy D, Picot S, et al. Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum. Malar J. 2012;11:45.
43. Brandicourt O, Druilhe P, Diouf F, Brasseur P, Turk P, Danis M. Decreased sensitivity to chloroquine and quinine of some Plasmodium falciparum strains from Senegal in september 1984. Am J Trop Med Hyg. 1986;35:717-21.
44. Pradines B, Tall A, Parzy D, Spiegel A, Fusai T, Hienne R, et al. In vitro activity of pyronaridine and amodiaquine against African isolates (Senegal) of Plasmodium falciparum in comparison with standard antimalarial agents. J Antimicrob Chemother. 1998;42:333-9.
45. Pradines B, Tall A, Ramiandrasoa F, Spiegel A, Sokhna C, Fusai T, et al. In vitro activity of iron-binding compounds against Senegalese isolates of Plasmodium falciparum. J Antimicrob Chemother. 2006;57:1093-9.
46. Jelinek T, Schelbert P, Loscher T, Eichenlaub D. Quinine resistant falciparum malaria acquired in east Africa. Trop Med Parasitol. 1995;46:38-40.
47. Palmieri F, Petrosillo N, Paglia MG, Conte A, Goletti D, Pucillo LP, et al. Genetic confirmation of quinine-resistant Plasmodium falciparum malaria followed by postmalaria neurological syndrome in a traveler from Mozambique. J Clin Microbiol. 2004;42:5424-6.
48. Pradines B, Pistone T, Ezzedine K, Briolant S, Bertaux L, Receveur MC, et al. Quinine-resistant malaria in traveler returning from Senegal, 2007. Emerg Infect Dis. 2010;16:546-8.
49. Pascual A, Henry M, Briolant S, Charras S, Baret E, Amalvict R, et al. In vitro activity of Proveblue (methylene blue) on Plasmodium falciparum strains resistant to standard antimalarial drugs. Antimicrob Agents Chemother. 2011;55:2472-4.
50. Dormoi J, Pascual A, Briolant S, Amalvict R, Charras S, Baret E, et al. Proveblue (methylene blue) as antimalarial agent: in vitro synergy with dihydroartemisinin and atorvastatin. Antimicrob Agents Chemother. 2012;56:3467-9.
51. Dormoi J, Briolant S, Desgrouas C, Pradines B. Efficacy of Proveblue (methylene blue) in an experimental cerebral murine model. Antimicrob Agents Chemother. 2013;57:3412-4.
52. Dormoi J, Briolant S, Desgrouas C, Pradines B. Impact of methylene blue and atorvastatin combination therapy on the apparition of cerebral malaria in a murine model. Malar J. 2013;12:127.
53. Dormoi J, Pradines B. Dose responses of Proveblue methylene blue in an experimental murine cerebral malaria model. Antimicrob Agents Chemother. 2013;57:4080-1.
54. Ademowo OG, Nneji CM, Adedapo AD. In vitro antimalarial activity of methylene blue against field isolates of Plasmodium falciparum from children in Southeast Nigeria. Indian J Med Res. 2007;126:45-9.
55. Okombo J, Kiara SM, Mwai L, Pole L, Ohuma E, Ochola LI, et al. Baseline of the activities of the antimalarials pyronaridine and methylene blue against Plasmodium falciparum isolates from Kenya. Antimicrob Agents Chemother. 2012;56:1105-7.
56. Suwanarusk R, Russel B, Ong A, Sriprawat K, Chu CS, Phyo AP, et al. Methylene blue inhibits the asexual development of vivax malaria parasites from a region of increasing chloroquine resistance. J Antimicrob Chemother. 2014. in press.
57. Adjalley SH, Jonhston GL, Li T, Eastman RT, Ekland EH, Eappen AG, et al. Quantitative assessment of Plasmodium falciparum sexual development revels potent transmission-blocking activity by methylene blue. Proc Natl Acad Sci U S A. 2011;108:1214-23.
58. Coulibaly B, Zoungrana A, Mockenhaupt FP, Schirmer RH, Klose C, Mansmann U, et al. Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomized control trial. PLoS One. 2009;4:5318.