The gut connectome: Making sense of what you eat

Journal of Clinical Investigation

Volumn 125, Issue 3, 2015, Pages 888-890

  Bohórquez, Diego V ^a   Liddle, Rodger A ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMNION FLUID; APPETITE; BODY WEIGHT; CONNECTOME; DIGESTIVE SYSTEM; ENTEROENDOCRINE CELL; EPITHELIUM CELL; GASTROINTESTINAL MOTILITY DISORDER; INTESTINE; INTESTINE INNERVATION; MYENTERIC PLEXUS; NERVE CELL; NEURAL CREST CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; STOMACH BYPASS; DIET; GASTROINTESTINAL TRACT; HUMAN; INNERVATION;

CONNECTOME; DIET; GASTROINTESTINAL TRACT; HUMANS;

EID: 84924083372     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI81121     Document Type: Review

References (30)

1. Brillat-Savarin JA. The physiology of taste: or meditations on transcendental gastronomy. Washington, DC, USA: The Heritage Press; 1949.
2. Avetisyan M, Schill EM, Heuckeroth RO. Building a second brain in the bowel. J Clin Invest. 2015;125(3):899-907.
3. Furness JB. Types of neurons in the enteric nervous system. J Auton Nerv Syst. 2000;81(1-3):87-96.
4. Lake JI, Heuckeroth RO. Enteric nervous system development: migration, differentiation, and disease. Am J Physiol Gastrointest Liver Physiol. 2013;305(1):G1-G24.
5. Aagaard K, Ma J, Antony KM, Ganu R, Petrosino J, Versalovic J. The placenta harbors a unique microbiome. Sci Transl Med. 2014;6(237):237ra65.
6. Nicholson JK, et al. Host-gut microbiota metabolic interactions. Science. 2012; 336(6086):1262-1267.
7. Kabouridis PS, Pachnis V. Emerging roles of gut microbiota and the immune system on the development of the enteric nervous system. J Clin Invest. 2015;125(3):956-964.
8. Bogunovic M, et al. Enteroendocrine cells express functional Toll-like receptors. Am J Physiol Gastrointest Liver Physiol. 2007;292(6):G1770-G1783.
9. Mawe GM. Colitis-induced neuroplasticity disrupts motility in the inflamed and post-inflamed colon. J Clin Invest. 2015;125(3):949-955.
10. Mellitzer G, et al. Loss of enteroendocrine cells in mice alters lipid absorption and glucose homeostasis and impairs postnatal survival. J Clin Invest. 2010;120(5):1708-1721.
11. Psichas A, Reimann F, Gribble FM. Gut chemosensing mechanisms. J Clin Invest. 2015;125(3):908-917.
12. Jang HJ,et al Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1 Proc Natl Acad Sci U S A. 2007 104,. 38. 15069-15074.
13. Braun T, Voland P, Kunz L, Prinz C, Gratzl M. Enterochromaffin cells of the human gut: sensors for spices and odorants. Gastroenterology. 2007;132(5):1890-1901.
14. Bohórquez DV, Samsa LA, Roholt A, Medicetty S, Chandra R, Liddle RA. An enteroendocrine cell-enteric glia connection revealed by 3D electron microscopy. PLoS One. 2014;9(2):e 89881.
15. Bohórquez DV, Shahid RA, Erdmann A, Kreger AM, Wang Y, Calakos N, Wang F, Liddle RA. Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells. J Clin Invest. 2015;125(2):782-786.
16. Cummings DE, Overduin J. Gastrointestinal regulation of food intake. J Clin Invest. 2007;117(1):13-23.
17. Chandra R, Wang Y, Sha hid RA, Vigna SR, Freedman NJ, Liddle RA. Immunoglobulin-like domain containing receptor 1 mediates fat-stimulated cholecystokinin secretion. J Clin Invest. 2013;123(8):3343-3352.
18. Liou AP, et al. The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. Gastroenterology. 2011;140(3):903-912.
19. DiPatrizio NV, Piomelli D. In testinal lipid-derived signals that sense dietary fat. J Clin Invest. 2015;125(3):891-898.
20. Dogiel AS. Ü ber den bau der ganglien in den geflechten des darmes und der gallenblase des menschen und der säugetiere . Arch Anat Physiol (Leipzig) Anat Abt Jg. 1899:130-158.
21. Bush TG, et al. Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell. 1998;93(2):189-201.
22. McClain JL, et al. Ca2+ responses in enteric glia are mediated by connexin-43 hemichannels and modulate colonic transit in mice. Gastroenterology. 2014;146(2):497-507 e1.
23. Sharkey KA. Emerging roles for enteric glia in gastrointestinal disorders. J Clin Invest. 2015;125(3):918-925.
24. Gautron L, Rutkowski JM, Burton MD, Wei W, Wan Y, E lmquist JK. Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen. J Comp Neurol. 2013;521(16):3741-3767.
25. Selgrad M, et al. JC virus infects the enteric glia of patients with chronic idiopathic intestinal pseudo-obstruction. Gut. 2009;58(1):25-32.
26. Mayer EA, Tillisch K, Gupta A. Gut/brain axis and the microbiota. J Clin Invest. 2015;125(3):926-938.
27. Mason EE, Ito C. Gastric bypass in obesity. Surg Clinics N Am. 1967;47:1345-1351.
28. Manning S, Pucci A, Batterham RL. Roux-en-Y gastric bypass: effects on feeding behavior and underlying mechanisms. J Clin Invest. 2015;125(3):939-948.
29. Courcoulas AP, et al. Weight change and health outcomes at 3 years after bariatric surgery among individuals with severe obesity. JAMA. 2013;310(22):2416-2425.
30. Pepino MY, Bradley D, Eagon JC, Sullivan S, Abumrad NA, Klein S. Changes in taste perception and eating behavior aft er bariatric surgery-induced weight loss in women. Obesity (Silver Spring). 2014;22(5):E13-E20.