Inhibition of oxidative phosphorylation for enhancing citric acid production by Aspergillusniger

Microbial Cell Factories

Volumn 14, Issue 1, 2015, Pages

  Wang, Lu ^a,b   Zhang, Jianhua ^a,b   Cao, Zhanglei ^a,b   Wang, Yajun ^a,b   Gao, Qiang ^a,b,c   Zhang, Jian ^a,b,c   Wang, Depei ^a,b,c  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c Tianjin Key Laboratory of Industrial Microbiology   (China)

Author keywords

Aspergillus niger; Citric acid; Energy metabolism; Oxidative phosphorylation inhibitor; Uncoupler of oxidative phosphorylation

Indexed keywords

2,4 DINITROPHENOL; ADENOSINE TRIPHOSPHATE; ANTIMYCIN A1; CITRIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ARTICLE; ASPERGILLUS NIGER; BACTERIAL GROWTH; ENERGY METABOLISM; ESCHERICHIA COLI; FERMENTATION; GLUCOSE METABOLISM; GLYCOLYSIS; GROWTH RATE; NONHUMAN; OXIDATION; OXIDATIVE PHOSPHORYLATION; SPORE GERMINATION; DRUG EFFECTS; FUNGUS SPORE; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PHYSIOLOGY;

ASPERGILLUS NIGER;

2,4-DINITROPHENOL; ADENOSINE TRIPHOSPHATE; ANTIMYCIN A; ASPERGILLUS NIGER; CITRIC ACID; ENERGY METABOLISM; NAD; OXIDATIVE PHOSPHORYLATION; SPORES, FUNGAL;

EID: 84924066715     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/s12934-015-0190-z     Document Type: Article

References (39)

1. Assimopoulou AN, Boskou D, Papageorgiou VP. Antioxidant activities of alkannin, shikonin and Alkanna tinctoria root extracts in oil substrates. Food Chem. 2004;87:433-8.
2. Soccol CR, Vandenberghe LPS, Rodrigues C, Pandey A. New perspectives for citric acid production and application. Food Technol Biotechnol. 2006;44(2):141-9.
3. Zahorsky B. U.S. Patent 1913; 1065358.
4. Currie JN. The citric acid fermentation of Aspergillus niger. J Biol Chem. 1917;31:15-37.
5. Wolschek MF, Kubicek CP. Biochemistry of citric acid accumulation by Aspergillus niger. In: Kristiansen B, Mattey M, Linden J, editors. Citric acid biotechnology. London: Taylor Francis Ltd; 1999.
6. Ruijter GJG, Kubicek CP, Visser J. Production of organic acids by fungi. Indust Appl. 2002;10:213-30.
7. Karaffa L, Kubicek CP. Aspergillus niger citric acid accumulation: do we understand this well working black box? Appl Microbiol Biotechnol. 2003;61(3):189-96.
8. Torres NV. Modeling approach to control of carbohydrate metabolism during citric acid production by Aspergillus niger: I. Model definition and stability of the steady state. Biotechnol Bioeng. 1994;44:104-11.
9. Torres NV. Modeling approach to control of carbohydrate metabolism during citric acid production by Aspergillus niger: II. Sensitivity analysis. Biotechnol Bioeng. 1994;44:112-8.
10. Habison A, Kubicek CP, Röhr M. Phosphofructokinase as a regulatory enzyme in citric acid producing Aspergillus niger. FEMS Microbiol Lett. 1979;5:39-42.
11. Vankuyk PA, Diderich JA, MacCabe AP, Hererro O, Ruijter GJG, Visser J. Aspergillus niger mstA encodes a high-affinity sugar/H+ symporter which is regulated in response to extracellular pH. Biochem J. 2004;379:375-83.
12. Schmid A, Dordick JS, Hauer B, Kiener A, Wubbolts M, Witholt B. Industrial biocatalysis today and tomorrow. Nature. 2001;409:258-68.
13. Larsson C, Nilsson A, Blomberg A, Gustafsson L. Glycolytic flux is conditionally correlated with ATP concentration in Saccharomyces cerevisiae: a chemostat study under carbon- or nitrogen-limiting conditions. J Bacteriol. 1997;179(23):7243-50.
14. Thomas S, Fell DA. A control analysis exploration of the role of ATP utilisation in glycolytic-flux control and glycolytic-metabolite-concentration regulation. Eur J Biochem. 1998;258(3):956-67.
15. Vemuri GN, Eiteman MA, McEwen JE, Olsson L, Nielsen J. Increasing NADH oxidation reduces overflow metabolism in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2007;104(7):2402-7.
16. Neves AR, Ventura R, Mansour N, Shearman C, Gasson MJ, Maycock C, et al. Is the glycolytic flux in Lactococcus lactis primarily controlled by the redox charge? Kinetic of NAD+ and NADH pools determined in vivo by 13C NMR. J Biol Chem. 2002;277(31):28088-98.
17. Jensen PR, Michelsen O. Carbon and energy metabolism of atp mutants of Escherichia coli. J Bacteriol. 1992;174(23):7635-41.
18. Koebmann BJ, Westerhoff HV, Snoep JL, Nilsson D, Jensen PR. The glycolytic flux in Escherichia coli is controlled by the demand for ATP. J Bacteriol. 2002;184(14):3909-16.
19. Liu LM, Li Y, Li HZ, Chen J. Significant increase of glycolytic flux in Torulopsis glabrata by inhibition of oxidative phosphorylation. FEMS Yeast Res. 2006;6(8):1117-29.
20. Abo-Khatwa AN, Al-Robai AA, Al-Jawhari DA. Lichen acids as uncouplers of oxidative phosphorylation of mouse-liver mitochondria. Nat Toxins. 1996;4:96-102.
21. Dietzler DN, Leckie MP, Magnani JL, Sughrue MJ, Bergstein PE. Evidence for the coordinate control of glycogen synthesis, glucose utilization, and glycolysis in Escherichia coli. II. Quantitative correlation of the inhibition of glycogen synthesis and the stimulation of glucose utilization by 2,4-dinitrophenol with the effects on the cellular levels of glucose 6-phosphate, fructose 1,6-diphosphate, and total adenylates. J Biol Chem. 1975;250(18):7195-203.
22. Day DA, Wiskich JT. Regulation of alternative oxidase activity in higher plants. J Bioenerg Biomembr. 1995;27:379-85.
23. Vanlerberghe GC, McIntosh L. Alternative oxidase: from gene to function. Annu Rev Plant Physiol Plant Mol Biol. 1997;48:703-34.
24. Kirimura K, Hirowatari Y, Usami S. Alterations of respiratory systems in Aspergillus niger under the conditions of citric acid fermentation. Agric Biol Chem. 1987;51:1299-303.
25. Edwards DL, Kwiecinski F. Altered mitochondrial respiration in a chromosomal mutant of Neurospora crassa. J Bacteriol. 1973;116(2):610-8.
26. Edwards DL, Rosenberg E, Maronev PA. Induction of cyanide-resistant respiration in Neurospora crassa. J Biol Chem. 1974;249:3551-6.
27. Minagawa N, Yoshimoto A. The induction of cyanide-resistant respiration in Hansenula anomala. J Biothem. 1987;101(5):1141-6.
28. Minagawa N, Sakajo S, Komiyama T, Yoshimoto A. A 36-kDa mitochondrial protein is responsible for cyanide-resistant respiration in Hansenula anomala. FEBS Lett. 1990;264:149-52.
29. Hattori T, Kino K, Kirimura K. Regulation of alternative oxidase at the transcription stage in Aspergillus niger under the conditions of citric acid production. Curr Microbiol. 2009;58(4):321-5.
30. Kubicek CP, Zehentgruber O, EI-Kalak H, Röhr M. Regulation of citric acid production by oxygen:Effect of dissolve oxygen tension on adenylate levels and respairation in Aspergillus niger. Eur J Appl Microbiol Biotechnol. 1980;9:101-15.
31. Prömper C, Schneider R, Weiss H. The role of the proton-pumping and alternative respiratory chain NADH: ubiquinone oxidoreductases in overflow catabolism of Aspergillus niger. Eur J Biochem. 1993;216:223-30.
32. Kirimura K, Matsui T, Sugano S, Usami S. Enhancement and repression of cyanide-insensitive respiration in Aspergillus niger. FEMS Microbiol Lett. 1996;141:251-4.
33. Atlas RM. Handbook of Microbiological Media. 2nd ed. CRC Pr I Llc. 1997; 283-84.
34. Hu RH, Lin L, Liu TJ, Ouyang PK, He BH, Liu SJ. Reducing sugar content in Hemicellulose hydrolylase by DNS method: a revisit. J Biobased Mater Biol. 2008;2:156-61.
35. Menzel K, Ahrens K, Zeng AP, Deckwer WD. Kinetic, dynamic, and pathway studies of glycerol metabolism by Klebsiella pneumoniae in anaerobic continuous culture: IV. Enzymes and fluxes of pyruvate metabolism. Biotechnol Bioeng. 1998;60(5):617-26.
36. Du CY, Yan H, Zhang YP, Li Y, Cao Z. Use oxidoreduction potential as an indicator to regulate 1,3-propanediol fermentation by Klebsiella pneumoniae. Appl Microbiol Biotechnol. 2006;69:554-63.
37. Lilius EM, Multanen VM, Toivonen V. Quantitative extraction and estimation of intracellular nicotinamid dinucleotides in Escherichia coli. Anal Biochem. 1979;99(1):22-7.
38. Stanley PE. Extraction of adenosine triphosphate from microbial and somatic acid. Methods Enzymol. 1986;133:14-22.
39. Miseta A, Tökés-füzesi M, Aiello DP, Bedwell DM. A Saccharomyces cerevisiae mutant unable to convert glucose to glucose-6-phosphate accumulates excessive glucose in the endoplasmic reticulum due to core oligosaccharide trimming. Eukaryot Cell. 2003;2(3):534-41.