Inhibition of the AKT pathway in cholangiocarcinoma by MK2206 reduces cellular viability via induction of apoptosis

Cancer Cell International

Volumn 15, Issue 1, 2015, Pages

  Wilson, Jacob M ^a   Kunnimalaiyaan, Selvi ^a   Kunnimalaiyaan, Muthusamy ^a   Gamblin, T Clark ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Apoptosis; Cholangiocarcinoma; MK2206; PI3K mTOR AKT

Indexed keywords

8 [4 (1 AMINOCYCLOBUTYL)PHENYL] 9 PHENYL 1,2,4 TRIAZOLO[3,4 F][1,6]NAPHTHYRIDIN 3(2H) ONE; PROCASPASE 3; PROCASPASE 9; PROTEIN KINASE B; SMALL INTERFERING RNA; SURVIVIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BILE DUCT CARCINOMA; CANCER INHIBITION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; PROTEIN CLEAVAGE; PROTEIN DEPLETION; PROTEIN EXPRESSION;

EID: 84924064100     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/s12935-015-0161-9     Document Type: Article

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