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Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 6, 2015, Pages 1292-1296

Structural and biological evaluation of a novel series of benzimidazole inhibitors of Francisella tularensis enoyl-ACP reductase (FabI)

(13) Mehboob, Shahila a,b Song, Jinhua c,d Hevener, Kirk E a,g Su, Pin Chih a Boci, Teuta a Brubaker, Libby a Truong, Lena a Mistry, Tina a Deng, Jiangping e,f Cook, James L e,f Santarsiero, Bernard D a Ghosh, Arun K c,d Johnson, Michael E a,b

a UNIVERSITY OF ILLINOIS AT CHICAGO (United States)

b Novalex Therapeutics (United States)

c PURDUE UNIVERSITY (United States)

d PURDUE UNIVERSITY (United States)

e LOYOLA UNIVERSITY CHICAGO (United States)

f HINES VA HOSPITAL (United States)

g IDAHO STATE UNIVERSITY (United States)

Author keywords

Benzimidazole scaffold; Enoyl reductase; F. tularensis; FabI inhibitor; MRSA; S. aureus

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; ENOYL ACYL CARRIER PROTEIN REDUCTASE (NADH); ENOYL ACYL CARRIER PROTEIN REDUCTASE INHIBITOR; PROTEIN FABI; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BENZIMIDAZOLE; ENZYME INHIBITOR;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG SCREENING; ENZYME ACTIVITY; FRANCISELLA TULARENSIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM BACTERICIDAL CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; TULAREMIA; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; DRUG EFFECTS; ENZYME ACTIVE SITE; ENZYMOLOGY; ESCHERICHIA COLI; KINETICS; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR DYNAMICS; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); FRANCISELLA TULARENSIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NEGIBACTERIA; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BENZIMIDAZOLES; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENOYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (NADH); ENZYME INHIBITORS; ESCHERICHIA COLI; FRANCISELLA TULARENSIS; KINETICS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MOLECULAR DYNAMICS SIMULATION; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84924042366 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.01.048 Document Type: Article

Times cited : (19)

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