Pneumococcal meningitis and vaccine effects in the era of conjugate vaccination: Results of 20 years of nationwide surveillance in Germany

BMC Infectious Diseases

Volumn 15, Issue 1, 2015, Pages

  Imöhl, Matthias ^a   Möller, Jens ^a   Perniciaro, Stephanie ^a   van der Linden, Mark ^a   Aktas, Orhan ^b  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b Department of Orthopedic Surgery   (Germany)

Author keywords

Age; Antibiotic susceptibility; Meningitis; Serotypes; Streptococcus pneumoniae; Vaccine coverage

Indexed keywords

PNEUMOCOCCUS VACCINE; VACCINE;

ADOLESCENT; ADULT; AGED; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIUM ISOLATE; BROTH DILUTION; CHILD; CONTROLLED STUDY; DISEASE SURVEILLANCE; DRUG EFFECT; EPIDEMIOLOGICAL MONITORING; FEMALE; GERMANY; HERD IMMUNITY; HUMAN; INFECTION PREVENTION; MAJOR CLINICAL STUDY; MALE; NEWBORN; PNEUMOCOCCAL MENINGITIS; SEROTYPE; VACCINATION; CLASSIFICATION; IMMUNOLOGY; INFANT; MENINGITIS, PNEUMOCOCCAL; MICROBIOLOGY; MIDDLE AGED; PRESCHOOL CHILD; PREVALENCE; PROCEDURES; SEROTYPING; STATISTICS AND NUMERICAL DATA; STREPTOCOCCUS PNEUMONIAE; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; EPIDEMIOLOGICAL MONITORING; FEMALE; GERMANY; HUMANS; INFANT; INFANT, NEWBORN; MALE; MENINGITIS, PNEUMOCOCCAL; MIDDLE AGED; PNEUMOCOCCAL VACCINES; PREVALENCE; SEROTYPING; STREPTOCOCCUS PNEUMONIAE; VACCINATION; VACCINES, CONJUGATE; YOUNG ADULT;

EID: 84924020198     PISSN: None     EISSN: 14712334     Source Type: Journal    
DOI: 10.1186/s12879-015-0787-1     Document Type: Article

References (45)

1. Austrian R. Pneumococcus: the first one hundred years. Rev Infect Dis. 1981;3(2):183-9.
2. Levy C, Varon E, Bingen E, Picard C, de La Rocque F, Aujard Y, et al. [Pneumococcal meningitis in children in France: 832 cases from 2001 to 2007]. Arch Pediatr. 2008;15 Suppl 3:S111-8.
3. von Kries R, Hermann M, Hachmeister A, Siedler A, Schmitt HJ, Al-Lahham A, et al. Prediction of the potential benefit of different pneumococcal conjugate vaccines on invasive pneumococcal disease in German children. Pediatr Infect Dis J. 2002;21(11):1017-23.
4. Casado Flores J, Fenoll A, Aristegui Fernandez J, Rodrigo De Liria C, Martinon Sanchez JM, Berron S, et al. [Pneumococcal meningitis in Spanish children: incidence, serotypes and antibiotic resistance. Prospective and multicentre study]. An Esp Pediatr. 2002;57(4):295-300.
5. Johnson AP, Waight P, Andrews N, Pebody R, George RC, Miller E. Morbidity and mortality of pneumococcal meningitis and serotypes of causative strains prior to introduction of the 7-valent conjugant pneumococcal vaccine in England. J Infect. 2007;55(5):394-9.
6. Stanek RJ, Mufson MA. A 20-year epidemiological study of pneumococcal meningitis. Clin Infect Dis. 1999;28(6):1265-72.
7. Reinert RR. Pneumococcal conjugate vaccines-a European perspective. Int J Med Microbiol. 2004;294(5):277-94.
8. Quagliarello V, Scheld WM. Bacterial meningitis: pathogenesis, pathophysiology, and progress. N Engl J Med. 1992;327(12):864-72.
9. Hammerschmidt S, Wolff S, Hocke A, Rosseau S, Muller E, Rohde M. Illustration of pneumococcal polysaccharide capsule during adherence and invasion of epithelial cells. Infect Immun. 2005;73(8):4653-67.
10. Braun JS, Sublett JE, Freyer D, Mitchell TJ, Cleveland JL, Tuomanen EI, et al. Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis. J Clin Invest. 2002;109(1):19-27.
11. Hoffmann O, Priller J, Prozorovski T, Schulze-Topphoff U, Baeva N, Lunemann JD, et al. TRAIL limits excessive host immune responses in bacterial meningitis. J Clin Invest. 2007;117(7):2004-13.
12. de Gans J, van de Beek D. Dexamethasone in adults with bacterial meningitis. N Engl J Med. 2002;347(20):1549-56.
13. Greenwood BM. Corticosteroids for acute bacterial meningitis. N Engl J Med. 2007;357(24):2507-9.
14. de Sevilla MF, Garcia-Garcia JJ, Esteva C, Moraga F, Hernandez S, Selva L, et al. Clinical presentation of invasive pneumococcal disease in Spain in the era of heptavalent conjugate vaccine. Pediatr Infect Dis J. 2012;31(2):124-8.
15. Ladhani SN, Slack MP, Andrews NJ, Waight PA, Borrow R, Miller E. Invasive pneumococcal disease after routine pneumococcal conjugate vaccination in children, England and Wales. Emerg Infect Dis. 2013;19(1):61-8.
16. Pichon B, Ladhani SN, Slack MP, Segonds-Pichon A, Andrews NJ, Waight PA, et al. Changes in molecular epidemiology of Streptococcus pneumoniae causing meningitis following introduction of pneumococcal conjugate vaccination in England and Wales. J Clin Microbiol. 2013;51(3):820-7.
17. Elberse KE, van der Heide HG, Witteveen S, van de Pol I, Schot CS, van der Ende A, et al. Changes in the composition of the pneumococcal population and in IPD incidence in The Netherlands after the implementation of the 7-valent pneumococcal conjugate vaccine. Vaccine. 2012;30(52):7644-51.
18. Myint TT, Madhava H, Balmer P, Christopoulou D, Attal S, Menegas D, et al. The impact of 7-valent pneumococcal conjugate vaccine on invasive pneumococcal disease: a literature review. Adv Ther. 2013;30(2):127-51.
19. Imöhl M, Reinert RR, Ocklenburg C, van der Linden M. Association of serotypes of Streptococcus pneumoniae with age in invasive pneumococcal disease. J Clin Microbiol. 2010;48(4):1291-6.
20. Clinical Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; twenty-fourth informational supplement. Wayne, PA;2014.
21. Ständige Impfkommission (STIKO). Empfehlungen der Ständigen Impfkommission (STIKO) am Robert Koch-Institut (Stand Juli 2006):Begründungen zur allgemeinen Empfehlung der Impfungen gegen Pneumokokken- und Meningokokken im Säuglings- und Kindesalter. Epidemiolgisches Bulletin. 2006;(31):255-260.
22. McIntyre PB, O'Brien KL, Greenwood B, van de Beek D. Effect of vaccines on bacterial meningitis worldwide. Lancet. 2012;380(9854):1703-11.
23. van der Linden M, Weiss S, Falkenhorst G, Siedler A, Imöhl M, von Kries R. Four years of universal pneumococcal conjugate infant vaccination in Germany: Impact on incidence of invasive pneumococcal disease and serotype distribution in children. Vaccine. 2012;30(40):5880-5.
24. Hsu HE, Shutt KA, Moore MR, Beall BW, Bennett NM, Craig AS, et al. Effect of pneumococcal conjugate vaccine on pneumococcal meningitis. N Engl J Med. 2009;360(3):244-56.
25. Casado-Flores J, Rodrigo C, Aristegui J, Martinon JM, Fenoll A, Mendez C. Decline in pneumococcal meningitis in Spain after introduction of the heptavalent pneumococcal conjugate vaccine. Pediatr Infect Dis J. 2008;27(11):1020-2.
26. Stephens DS. Protecting the herd: the remarkable effectiveness of the bacterial meningitis polysaccharide-protein conjugate vaccines in altering transmission dynamics. Trans Am Clin Climatol Assoc. 2011;122:115-23.
27. Pantosti A, D'Ambrosio F, Tarasi A, Recchia S, Orefici G, Mastrantonio P. Antibiotic susceptibility and serotype distribution of Streptococcus pneumoniae causing meningitis in Italy, 1997-1999. Clin Infect Dis. 2000;31(6):1373-9.
28. Verhaegen J, Vandecasteele SJ, Vandeven J, Verbiest N, Lagrou K, Peetermans WE. Antibiotic susceptibility and serotype distribution of 240 Streptococcus pneumoniae causing meningitis in Belgium 1997-2000. Acta Clin Belg. 2003;58(1):19-26.
29. Vieira AC, Gomes MC, Rolo Filho M, Eudes Filho J, Bello EJ, de Figueiredo RB. Streptococcus pneumoniae: a study of strains isolated from cerebrospinal fluid. J Pediatr (Rio J). 2007;83(1):71-8.
30. Imöhl M, Reinert RR, van der Linden M. Regional differences in serotype distribution, pneumococcal vaccine coverage, and antimicrobial resistance of invasive pneumococcal disease among German federal states. Int J Med Microbiol. 2009;300(4):237-47.
31. Imöhl M, Reinert RR, van der Linden M. Adult invasive pneumococcal disease between 2003 and 2006 in North-Rhine Westphalia, Germany: serotype distribution before recommendation for general pneumococcal conjugate vaccination for children <2 years of age. Clin Microbiol Infect. 2009;15(11):1008-12.
32. Feikin DR, Klugman KP, Facklam RR, Zell ER, Schuchat A, Whitney CG. Increased prevalence of pediatric pneumococcal serotypes in elderly adults. Clin Infect Dis. 2005;41(4):481-7.
33. Harboe ZB, Thomsen RW, Riis A, Valentiner-Branth P, Christensen JJ, Lambertsen L, et al. Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study. PLoS Med. 2009;6(5):e1000081.
34. Alexandre C, Dubos F, Courouble C, Pruvost I, Varon E, Martinot A. Rebound in the incidence of pneumococcal meningitis in northern France: effect of serotype replacement. Acta Paediatr. 2010;99(11):1686-90.
35. Rajasingham CR, Bonsu BK, Chapman JI, Cohen DM, Barson WJ. Serious neurologic sequelae in cases of meningitis arising from infection by conjugate vaccine-related and nonvaccine-related serogroups of Streptococcus pneumoniae. Pediatr Infect Dis J. 2008;27(9):771-5.
36. Nigrovic LE, Kuppermann N, Malley R. Children with bacterial meningitis presenting to the emergency department during the pneumococcal conjugate vaccine era. Acad Emerg Med. 2008;15(6):522-8.
37. Livermore DM. Bacterial resistance: origins, epidemiology, and impact. Clin Infect Dis. 2003;36 Suppl 1:S11-23.
38. Jacobs MR, Good CE, Beall B, Bajaksouzian S, Windau AR, Whitney CG. Changes in serotypes and antimicrobial susceptibility of invasive Streptococcus pneumoniae strains in Cleveland: a quarter century of experience. J Clin Microbiol. 2008;46(3):982-90.
39. Adam D. Global antibiotic resistance in Streptococcus pneumoniae. J Antimicrob Chemother. 2002;50(Suppl):1-5.
40. Felmingham D, Reinert RR, Hirakata Y, Rodloff A. Increasing prevalence of antimicrobial resistance among isolates of Streptococcus pneumoniae from the PROTEKT surveillance study, and compatative in vitro activity of the ketolide, telithromycin. J Antimicrob Chemother. 2002;50(Suppl S1):25-37.
41. Imöhl M, Reinert RR, van der Linden M. New penicillin susceptibility breakpoints for Streptococcus pneumoniae and their effects on susceptibility categorisation in Germany (1992-2008). Int J Antimicrob Agents. 2009;34(3):271-3.
42. Effects of new penicillin susceptibility breakpoints for Streptococcus pneumoniae--United States, 2006-2007. MMWR Morb Mortal Wkly Rep. 2008;57(50):1353-5.
43. Imöhl M, Reinert RR, Mutscher C, van der Linden M. Macrolide susceptibility and serotype specific macrolide resistance of invasive isolates of Streptococcus pneumoniae in Germany from 1992 to 2008. BMC Microbiol. 2010;10:299.
44. Skoczynska A, Hryniewicz W. Genetic relatedness, antibiotic susceptibility, and serotype distribution of Streptococcus pneumoniae responsible for meningitis in Poland, 1997-2001. Microb Drug Resist. 2003;9(2):175-82.
45. Sjostrom K, Spindler C, Ortqvist A, Kalin M, Sandgren A, Kuhlmann-Berenzon S, et al. Clonal and capsular types decide whether pneumococci will act as a primary or opportunistic pathogen. Clin Infect Dis. 2006;42(4):451-9.