Genetic association of fetal-hemoglobin levels in individuals with sickle cell disease in Tanzania maps to conserved regulatory elements within the MYB core enhancer

BMC Medical Genetics

Volumn 16, Issue 1, 2015, Pages

  Mtatiro, Siana N ^a,b,c   Mgaya, Josephine ^a   Singh, Tarjinder ^d   Mariki, Harvest ^a   Rooks, Helen ^c   Soka, Deogratius ^a   Mmbando, Bruno ^a,e   Thein, Swee Lay ^a,e   Barrett, Jeffrey C ^d   Makani, Julie ^a   Cox, Sharon E ^a,f   Menzel, Stephan ^c  

^a MUHIMBILI UNIVERSITY OF HEALTH AND ALLIED SCIENCES   (Tanzania)

^b UNIVERSITY OF DAR ES SALAAM   (Tanzania)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^e NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (Tanzania)

^f LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; HEMOGLOBIN F; HMIP 2 PROTEIN; HMIP 2A PROTEIN; PROTEIN MYB; UNCLASSIFIED DRUG; PROTEIN C MYB;

ALLELE; ARTICLE; CHILD; ENHANCER REGION; EUROPEAN; FEMALE; GENE FREQUENCY; GENE LOCATION; GENE LOCUS; GENE MAPPING; GENE TARGETING; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN GENOME; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; POPULATION GENETICS; QUANTITATIVE TRAIT LOCUS; SICKLE CELL ANEMIA; TANZANIA; WEST AFRICAN; CHROMOSOME MAP; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PRESCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

ANEMIA, SICKLE CELL; CHILD; CHILD, PRESCHOOL; CHROMOSOME MAPPING; CONSERVED SEQUENCE; ENHANCER ELEMENTS, GENETIC; FEMALE; FETAL HEMOGLOBIN; HAPLOTYPES; HUMANS; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTO-ONCOGENE PROTEINS C-MYB; QUANTITATIVE TRAIT LOCI; TANZANIA;

EID: 84923925187     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/s12881-015-0148-3     Document Type: Article

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