Elevated hepatocyte growth factor levels in osteoarthritis osteoblasts contribute to their altered response to bone morphogenetic protein-2 and reduced mineralization capacity

Bone

Volumn 75, Issue , 2015, Pages 111-119

  Abed, E ^a   Bouvard, B ^b,c   Martineau, X ^a   Jouzeau, J Y ^b,d   Reboul, P ^b   Lajeunesse, D ^a  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITÉ DE LORRAINE   (France)

^c ANGERS UNIVERSITY HOSPITAL   (France)

^d UNIVERSITY HOSPITAL OF NANCY   (France)

Author keywords

Bone morphogenetic protein 2; Hepatocyte growth factor; Osteoarthritis; Osteoblasts; Wnt signaling

Indexed keywords

5 (2,6 DICHLOROBENZYLSULFONYL) 3 [3,5 DIMETHYL 4 [2 (1 PYRROLIDINYLMETHYL) 1 PYRROLIDINYLCARBONYL] 1H PYRROL 2 YLMETHYLENE] 1,3 DIHYDRO 2H INDOL 2 ONE; ALIZARIN RED S; ALKALINE PHOSPHATASE; BETA CATENIN; BONE MORPHOGENETIC PROTEIN 2; LUCIFERASE; OSTEOCALCIN; SCATTER FACTOR; SMAD1 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1; WNT3A PROTEIN; BMP2 PROTEIN, HUMAN; HGF PROTEIN, HUMAN;

AGED; ARTICLE; BONE MINERALIZATION; CELL DIFFERENTIATION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME IMMUNOASSAY; FEMALE; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; MALE; OSTEOARTHRITIS; OSTEOBLAST; PATHOPHYSIOLOGY; PHENOTYPE; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIBIA; TOTAL KNEE REPLACEMENT; UPREGULATION; WESTERN BLOTTING; WNT SIGNALING PATHWAY; CELL CULTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; KNEE OSTEOARTHRITIS; METABOLISM; PATHOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

AGED; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEIN 2; CALCIFICATION, PHYSIOLOGIC; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEPATOCYTE GROWTH FACTOR; HUMANS; MALE; OSTEOARTHRITIS, KNEE; OSTEOBLASTS; POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

EID: 84923923937     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2015.02.001     Document Type: Article

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