Why is therapeutic misconception so prevalent?

Cambridge Quarterly of Healthcare Ethics

Volumn 24, Issue 2, 2015, Pages 231-241

  Lidz, Charles W ^a   Albert, Karen ^a   Appelbaum, Paul ^b   Dunn, Laura B ^c   Overton, Eve ^d   Pivovarova, Ekaterina ^e  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b Columbia University College of Physicians and Surgeons ^*  (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

clinical trials; informed consent; research ethics; therapeutic misconception

Indexed keywords

CLINICAL TRIAL (TOPIC); COMPREHENSION; ETHICS; HEALTH CARE DELIVERY; HUMAN; HUMAN EXPERIMENT; INFORMED CONSENT; RESEARCH ETHICS; RESEARCH SUBJECT; THERAPEUTIC MISCONCEPTION;

CLINICAL TRIALS AS TOPIC; COMPREHENSION; DELIVERY OF HEALTH CARE; ETHICS, RESEARCH; HUMAN EXPERIMENTATION; HUMANS; INFORMED CONSENT; RESEARCH SUBJECTS; THERAPEUTIC MISCONCEPTION;

EID: 84923923216     PISSN: 09631801     EISSN: 14692147     Source Type: Journal    
DOI: 10.1017/S096318011400053X     Document Type: Article

References (21)

1. Fried C. Medical Experimentation: Personal Integrity and Social Policy. New York : American Elsevier; 1974.
2. Appelbaum PS, Roth LH, Lidz C. The therapeutic misconception: Informed consent in psychiatric research. International Journal of Law and Psychiatry 1982; 5 (3-4): 319-29.
3. Appelbaum P, Lidz C. The therapeutic misconception. In: Emanual E, Crouch R, Lie R, Miller F, Wendler D, eds. The Oxford Textbook of Clinical Research Ethics. New York : Oxford University Press; 2008 : 633-44.
4. Appelbaum P, Roth L, Lidz C, Winslade W. False hopes and best data: Consent to research and the therapeutic misconception. Hastings Center Report 1987; 17 (2): 20-4.
5. Appelbaum PS, Lidz CW, Grisso T. Therapeutic misconception in clinical research: Frequency and risk factors. IRB 2004; 26 (2): 1-8.
6. Dunn L, Palmer B, Keehan M, Jeste D, Appelbaum P. Assessment of therapeutic misconception in older schizophrenia patients with a brief instrument. American Journal of Psychiatry 2006; 163 (3): 500-6.
7. Kim S, Schrock L, Wilson R, Frank S, Holloway R, Kieburtz K, et al. An approach to evaluating the therapeutic misconception. IRB 2009; 31 (5): 7-14.
8. Joffe S, Cook E, Cleary P, Clark J, Weeks J. Quality of informed consent: A new measure of understanding among research subjects. Journal of the National Cancer Institute 2001; 93 (2): 139-47.
9. Appelbaum P, Anatchkova M, Albert K, Dunn L, Lidz C. Therapeutic misconception in research subjects: Development and validation of a measure. Clinical Trials 2012; 9 :748-61.
10. Henderson G, Easter M, King N, Davis A, Rothschild B, Churchill L, et al. Therapeutic misconception in early phase gene transfer trials. Social Science in Medicine 2006; 62 (1): 239-53.
11. Appelbaum P, Lidz C. Re-evaluating the therapeutic misconception: Response to Miller and Joffe. Kennedy Institute of Ethics Journal 2006; 16 (4): 353-6.
12. Kimmelman J. The therapeutic misconception at 25: Treatment, research, and confusion. Hastings Center Report 2007; 37 (6): 36-42.
13. Dunn L, Lindamer L, Palmer B, Schneiderman L, Jeste D. Enhancing comprehension of consent for research in older patients with psychosis: A randomized study of a novel consent procedure. American Journal of Psychiatry 2001; 158 (11): 1911-13.
14. Woodsong C, Karim Q. A model designed to enhance informed consent: Experiences from the HIV Prevention Trials Network. American Journal of Public Health 2005; 95 (3): 412-19.
15. Kass NE, Sugarman J, Medley A, Fogarty L, Taylor H, Daugherty C, et al. An intervention to improve cancer patients' understanding of early-phase clinical trials. IRB 2009; 31 (3): 1-10.
16. Henderson G, Churchill L, Davis A, Easter M, Grady C, Joffe S, et al. Defining the therapeutic misconception: Problems and prospects. PLoS Medicine 2007; 3 (10): 1-4.
17. Horng S, Grady C. Misunderstanding in clinical research: Distinguishing therapeutic misconception, therapeutic misestimation and therapeutic optimism. IRB 2003; 25 (1): 11-16.
18. Sulmasy D, Astrow A, Me M, Sells D, Meropol N, Micco E, et al. The culture of faith and hope: Patients' justifications for their high estimations of expected therapeutic benefit when enrolling in early phase oncology trials. Cancer 2010; 116 : 3702-11.
19. Goffman E. Frame Analysis. New York : Harper Colophon; 1974.
20. Lidz C, Appelbaum P, Grisso T, Renaud M. Therapeutic misconception and the appreciation of risks in clinical trials. Social Science & Medicine 2004; 58 (9): 1689-97.
21. Lidz C, Appelbaum P. The therapeutic misconception: Problems and solutions. Medical Care 2002; 40 (Suppl): v55-63.