Assessment of therapeutic misconception in older schizophrenia patients with a brief instrument

American Journal of Psychiatry

Volumn 163, Issue 3, 2006, Pages 500-506

  Dunn, Laura B ^a   Palmer, Barton W ^b   Keehan, Monique ^b   Jeste, Dilip V ^b   Appelbaum, Paul S ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACADEMIC ACHIEVEMENT; ADULT; AGE; AGED; ARTICLE; CLINICAL RESEARCH; COGNITIVE DEFECT; DECISION MAKING; DEMOGRAPHY; DISEASE SEVERITY; EDUCATION; ELDERLY CARE; HUMAN; INSTRUMENT; MACARTHUR COMPETENCE ASSESSMENT TOOL FOR CLINICAL RESEARCH; MAJOR CLINICAL STUDY; NEUROPSYCHIATRY; PATIENT ATTITUDE; PRIORITY JOURNAL; PSYCHOMETRY; RESEARCH ETHICS; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SCORING SYSTEM; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; EDUCATIONAL STATUS; HEALTH STATUS; HOSPITALIZATION; INFORMED CONSENT; MENTAL CAPACITY; MIDDLE AGED; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; PSYCHOSIS; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; STANDARD; STATISTICS;

NEUROLEPTIC AGENT;

AGE FACTORS; AGED; ANTIPSYCHOTIC AGENTS; CLINICAL PROTOCOLS; COGNITION DISORDERS; DECISION MAKING; EDUCATIONAL STATUS; ETHICS, RESEARCH; HEALTH STATUS; HUMANS; INFORMED CONSENT; MENTAL COMPETENCY; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; PSYCHOMETRICS; PSYCHOTIC DISORDERS; QUESTIONNAIRES; RANDOMIZED CONTROLLED TRIALS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SEVERITY OF ILLNESS INDEX;

EID: 33645908486     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.163.3.500     Document Type: Article

References (44)

1. Appelbaum PS, Roth LH, Lidz CW, Benson P, Winslade W: False hopes and best data: consent to research and the therapeutic misconception. Hastings Cent Rep 1987; 17:20-25
2. Fried E: The therapeutic misconception, beneficence, and respect. Account Res 2001; 8:331-348
3. Lidz CW, Appelbaum PS: The therapeutic misconception: problems and solutions. Med Care 2002; 40:V55-V63
4. Joffe S, Cook EF, Clearly PD, Clark JW, Weeks JC: Quality of informed consent: a new measure of understanding among research subjects. J Natl Cancer Inst 2001; 93:139-147
5. Joffe S, Cook EF, Cleary PD, Clark JW, Weeks JC: Quality of informed consent in cancer clinical trials: a cross-sectional survey. Lancet 2001; 358:1772-1777
6. Daugherty C, Ratain MJ, Grochowski E, Stocking C, Kodish E, Mick R, Siegler M: Perceptions of cancer patients and their physicians involved in phase 1 trials. J Clin Oncol 1995; 13:1062-1072
7. Lidz CW, Appelbaum PS, Grisso T, Renaud M: Therapeutic misconception and the appreciation of risks in clinical trials. Soc Sci Med 2004; 58:1689-1697
8. Penman DT, Holland JC, Bahna GF, Morrow G, Schmale AH, Derogatis LR, Carnrike CL, Cherry R: Informed consent for investigational chemotherapy: patients' and physicians' perceptions. J Clin Oncol 1984; 2:849-855
9. Schaeffer MH, Krantz DS, Wichman A, Masur H, Reed E, Vinicky JK: The impact of disease severity on the informed consent process in clinical research. Am J Med 1996; 100:261-268
10. Featherstone K, Donovan JL: Random allocation or allocation at random? patients' perspectives of participation in a randomised controlled trial. BMJ 1998; 317:1177-1180
11. Appelbaum PS, Lidz CW, Grisso T: Therapeutic misconception in clinical research: frequency and risk factors. IRB 2004; 26:1-8
12. Thomson CenterWatch: Clinical Trials Listing Service Patient Resources: Clinical Trials: Schizophrenia and Schizoaffective Disorders. http://www.centerwatch.com/patient/studies/cat135.htm
13. Grisso T, Appelbaum PS: Assessing Competence to Consent to Treatment: A Guide for Physicians and Other Health Professionals. New York, Oxford University Press, 1998
14. Moser DJ, Schultz SK, Arndt S, Benjamin ML, Fleming FW, Brems CS, Paulsen JS, Appelbaum PS, Andreasen NC: Capacity to provide informed consent for participation in schizophrenia and HIV research. Am J Psychiatry 2002; 159:1201-1207
15. Kim SYH, Caine ED, Currier GW, Leibovici A, Ryan JM: Assessing the competence of persons with Alzheimer's disease in providing informed consent for participation in research. Am J Psychiatry 2001; 158:712-717
16. Carpenter WT, Gold JM, Lahti AC, Queern CA, Conley RR, Bartko JJ, Kovnick J, Appelbaum PS: Decisional capacity for informed consent in schizophrenia research. Arch Gen Psychiatry 2000; 57:533-538
17. Palmer BW, Dunn LB, Appelbaum PS, Mudaliar S, Thal L, Henry R, Golshan S, Jeste DV: Assessment of capacity to consent to research among older persons with schizophrenia, Alzheimer disease, or diabetes mellitus: comparison of a 3-item questionnaire with a comprehensive standardized capacity instrument. Arch Gen Psychiatry 2005; 62:726-733
18. Appelbaum PS, Grisso T: MacCAT-CR: MacArthur Competence Assessment Tool for Clinical Research. Sarasota, Fla, Professional Resource Press, 2001
19. Appelbaum PS, Roth LH: Competency to consent to research: a psychiatric overview. Arch Gen Psychiatry 1982; 39:951-958
20. Kay SR, Fiszbein A, Opler LA: The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull 1987; 13:261-276
21. Hamilton M: A rating scale for depression. J Neurol Neurosurg Psychiatry 1960; 23:56-62
22. Birchwood M, Smith V, Drury V: A self-report insight scale for psychosis: reliability, validity and sensitivity to change. Acta Psychiatr Scand 1994; 89:62-67
23. Mattis S: Dementia Rating Scale. Odessa, FIa, Psychological Assessment Resources, 1973
24. Evans JD, Heaton RK, Paulsen JS, McAdams LA, Heaton SC, Jeste DV: Schizoaffective disorder: a form of schizophrenia or affective disorder? J Clin Psychiatry 1999; 60:874-882
25. Tsuang D, Coryell W: An 8-year follow-up of patients with DSM-III-R psychotic depression, schizoaffective disorder, and schizophrenia. Am J Psychiatry 1993; 150:1182-1188
26. Maj M, Starace F, Pirozzi R: A family study of DSM-III-R schizoaffective disorder, depressive type, compared with schizophrenia and psychotic and nonpsychotic major depression. Am J Psychiatry 1991; 148:612-616
27. Anastasi A, Urbina S: Psychological Testing, 7th ed. Upper Saddle River, NJ, Prentice Hall, 1997
28. Roberts LW, Warner TD, Brody JL, Roberts B, Lauriello J, Lyketsos C: Patient and psychiatrist ratings of hypothetical schizophrenia research protocols: assessment of harm potential and factors influencing participation decisions. Am J Psychiatry 2002; 159:573-584
29. Palmer BW, Dunn LB, Appelbaum PS, Jeste DV: Correlates of treatment-related decision-making capacity among middle-aged and older patients with schizophrenia. Arch Gen Psychiatry 2004; 61:230-236
30. Aaronson NK, Visser-Pol E, Leenhouts GHMW, Muller MJ, van der Schot ACM, van Dam FSAM, Keus RB, Koning CCE, ten Bokkel Huinink WW, van Dongen JA, Dubbelman R: Telephone-based nursing intervention improves the effectiveness of the informed consent process in cancer clinical trials. J Clin Oncol 1996; 14:984-996
31. Appelbaum PS, Grisso T: Assessing patients' capacities to consent to treatment. N Engl J Med 1988; 319:1635-1638; correction, 1989; 320:748
32. Flory J, Emanuel E: Interventions to improve research participants' understanding in informed consent for research: a systematic review. JAMA 2004; 292:1593-1601
33. Stanley B, Guido J, Stanley M, Shortell D: The elderly patient and informed consent: empirical findings. JAMA 1984; 252: 1302-1306
34. Grisso T, Appelbaum PS: The MacArthur Treatment Competence Study, III: abilities of patients to consent to psychiatric and medical treatments. Law Hum Behav 1995; 19:149-174
35. Lasser RA, Bossie CA, Zhu Y, Gharabawi G, Eerdekens M, Davidson M: Efficacy and safety of long-acting risperidone in elderly patients with schizophrenia and schizoaffective disorder. Int J Geriatr Psychiatry 2004; 19:898-905
36. Kane JM, Eerdekens M, Lindenmayer J-P, Keith SJ, Lesem M, Karcher K: Long-acting injectable risperidone: efficacy and safety of the first long-acting atypical antipsychotic. Am J Psychiatry 2003; 160:1125-1132
37. Waggoner WC, Mayo DM: Who understands? a survey of 25 words or phrases commonly used in proposed clinical research consent forms. IRB 1995; 17:6-9
38. Dickert N, Grady C: What's the price of a research subject? approaches to payment for research participation. N Engl J Med 1999; 341:198-203
39. Dunn LB, Gordon NE: Improving informed consent and enhancing recruitment for research by understanding economic behavior. JAMA 2005; 293:609-612
40. Dunn LB, Lindamer LA, Palmer BW, Golshan S, Schneiderman LJ, Jeste DV: Improving understanding of research consent in middle-aged and elderly patients with psychotic disorders. Am J Geriatr Psychiatry 2002; 10:142-150
41. Dunn LB, Jeste DV: Problem areas in the understanding of informed consent: study of middle-aged and older patients with psychotic disorders. Psychopharmacology (Berl) 2003; 171:81-85
42. Wirshing DA, Wirshing WC, Marder SR, Liberman RP, Mintz J: Informed consent: assessment of comprehension. Am J Psychiatry 1998; 155:1508-1511
43. Pincus HA, Lieberman JA, Ferris S: Ethics in Psychiatric Research: A Resource Manual for Human Subjects Protection. Washington, DC, American Psychiatric Association, 1999
44. Michels R: Are research ethics bad for our mental health? N Engl J Med 1999; 340:1427-1430