Metabolic glycoengineering sensitizes drug-resistant pancreatic cancer cells to tyrosine kinase inhibitors erlotinib and gefitinib

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 6, 2015, Pages 1223-1227

  Mathew, Mohit P ^a   Tan, Elaine ^a   Saeui, Christopher T ^a   Bovonratwet, Patawut ^a   Liu, Lingshu ^a   Bhattacharya, Rahul ^a   Yarema, Kevin J ^a  

^a Johns Hopkins University   (United States)

Author keywords

Drug synergy; Epidermal growth factor receptor; Metabolic oligosaccharide engineering; Pancreatic cancer; Receptor tyrosine kinase inhibitor; Sialylation

Indexed keywords

ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; METABOLIC GLYCOENGINEERING DRUG; STAT PROTEIN; UNCLASSIFIED DRUG; PROTEIN KINASE INHIBITOR; QUINAZOLINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; DRUG RESISTANT PANCREATIC CANCER CELL; GENETICS; GLYCOSYLATION; HUMAN; HUMAN CELL; PANCREATIC CANCER CELL LINE; PHARMACOPHORE; PHOSPHORYLATION; SIALYLATION; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG POTENTIATION; DRUG RESISTANCE; METABOLIC ENGINEERING; METABOLISM; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; ERLOTINIB HYDROCHLORIDE; GLYCOSYLATION; HUMANS; METABOLIC ENGINEERING; PANCREATIC NEOPLASMS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; STAT TRANSCRIPTION FACTORS;

EID: 84923920602     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.01.060     Document Type: Article

References (45)

1. S. Hakomori Annu. Rev. Immunol. 2 1984 103
2. S. Sell Hum. Pathol. 21 1990 1003
3. A. Varki, R. Cummings, J. Esko, H. Freeze, P. Stanley, C.R. Bertozzi, G.W. Hart, E. Etzler, R. Kannagi, and P. Toole Essentials of Glycobiology 2nd ed. 2009 (Chapter 44)
4. Y. Kim, and A. Varki Glycoconjugate J. 14 1997 569
5. S.-I. Hakomori Proc. Natl. Acad. Sci. U. S. A. 99 2002 10231
6. M. Hedlund, E. Ng, A. Varki, and N.M. Varki Cancer Res. 68 2008 388
7. A. Dove Nat. Biotechnol. 19 2001 913
8. M.M. Fuster, and J.D. Esko Nat. Rev. Cancer 5 2005 526
9. Y.C. Liu, H.Y. Yen, C.Y. Chen, C.H. Chen, P.F. Cheng, Y.H. Juan, C.H. Chen, K.H. Khoo, C.J. Yu, P.C. Yang, T.L. Hsu, and C.H. Wong Proc. Natl. Acad. Sci. U. S. A. 108 2011 11332
10. J.-J. Park, J.Y. Yi, Y.B. Jin, Y.-J. Lee, J.-S. Lee, Y.-S. Lee, Y.-G. Ko, and M. Lee Biochem. Pharmacol. 83 2012 849
11. J. Du, M.A. Meledeo, Z. Wang, H.S. Khanna, V.D.P. Paruchuri, and K.J. Yarema Glycobiology 19 2009 1382
12. D.H. Dube, and C.R. Bertozzi Curr. Opin. Chem. Biol. 7 2003 616
13. C.T. Campbell, S.-G. Sampathkumar, C. Weier, and K.J. Yarema Mol. Biosys. 3 2007 187
14. H. Kayser, R. Zeitler, C. Kannicht, D. Grunow, R. Nuck, and W. Reutter J. Biol. Chem. 267 1992 16934
15. O.T. Keppler, R. Horstkorte, M. Pawlita, C. Schmidt, and W. Reutter Glycobiology 11 2001 11R
16. M.B. Jones, H. Teng, J.K. Rhee, G. Baskaran, N. Lahar, and K.J. Yarema Biotechnol. Bioeng. 85 2004 394
17. E.J. Kim, S.-G. Sampathkumar, M.B. Jones, J.K. Rhee, G. Baskaran, and K.J. Yarema J. Biol. Chem. 279 2004 18342
18. R.T. Almaraz, U. Aich, H.S. Khanna, E. Tan, R. Bhattacharya, S. Shah, and K.J. Yarema Biotechnol. Bioeng. 109 2012 992
19. A.K. Sarkar, T.A. Fritz, W.H. Taylor, and J.D. Esko Proc. Natl. Acad. Sci. U. S. A. 92 1995 3323
20. A.K. Sarkar, K.S. Rostand, R.K. Jain, K.L. Matta, and J.D. Esko J. Biol. Chem. 272 1997 25608
21. G.A. Lemieux, K.J. Yarema, C.L. Jacobs, and C.R. Bertozzi J. Am. Chem. Soc. 121 1999 4278
22. S.-G. Sampathkumar, M.B. Jones, M.A. Meledeo, C.T. Campbell, S.S. Choi, K. Hida, P. Gomutputra, A. Sheh, T. Gilmartin, S.R. Head, and K.J. Yarema Chem. Biol. 13 2006 1265
23. M.P. Mathew, E. Tan, S. Shah, R. Bhattacharya, M.A. Meledeo, J. Huang, F.A. Espinoza, and K.J. Yarema Bioorg. Med. Chem. Lett. 22 2012 6929
24. M.C.V. Malicdan, S. Noguchi, T. Tokutomi, Y.-I. Goto, I. Nonaka, Y.K. Hayashi, and I. Nishino J. Biol. Chem. 287 2012 2689
25. E.J. Kim, M.B. Jones, J.K. Rhee, S.-G. Sampathkumar, and K.J. Yarema Biotechnol. Progr. 20 2004 1674
26. S.-G. Sampathkumar, C.T. Campbell, C. Weier, and K.J. Yarema Drugs Future 31 2006 1099
27. C.T. Campbell, U. Aich, C.A. Weier, J.J. Wang, S.S. Choi, M.M. Wen, K. Maisel, S.-G. Sampathkumar, and K.J. Yarema J. Med. Chem. 51 2008 8135
28. Z. Wang, J. Du, P.-L. Che, M.A. Meledeo, and K.J. Yarema Curr. Opin. Chem. Biol. 13 2009 565
29. R. Schauer Hoppe-Seyler's Physiol. Chem. 351 1970 595
30. R. Schauer, H. Schmid, J. Pommerencke, M. Iwersen, and G. Kohla Adv. Exp. Med. Biol. 491 2001 325
31. G. Kohla, E. Stockfleth, and R. Schauer Neurochem. Res. 27 2002 583
32. Y. Shen, G. Kohla, A.L. Lrhorfi, B. Sipos, H. Kalthoff, G.J. Gerwig, J.P. Kamerling, R. Schauer, and J. Tiralongo Eur. J. Biochem. 271 2004 281
33. Y. Shen, J. Tiralongo, G. Kohla, and R. Schauer Biol. Chem. 385 2004 145
34. P. Shah, S. Yang, S. Sun, P. Aiyetan, K.J. Yarema, and H. Zhang Anal. Chem. 85 2013 3606
35. U. Aich, C.T. Campbell, N. Elmouelhi, C.A. Weier, S.G. Sampathkumar, S.S. Choi, and K.J. Yarema ACS Chem. Biol. 3 2008 230
36. H. Zhang, X.-J. Li, D.B. Martin, and R. Aebersold Nat. Biotechnol. 21 2003 660
37. R.T. Almaraz, Y. Tian, R. Bhattarcharya, E. Tan, S.-H. Chen, M.R. Dallas, L. Chen, Z. Zhang, H. Zhang, K. Konstantopoulos, and K.J. Yarema Mol. Cell. Proteomics 2012 10.1074/mcp.M1112.017558
38. C.-H. Yun, K.E. Mengwasser, A.V. Toms, M.S. Woo, H. Greulich, K.-K. Wong, M. Meyerson, and M.J. Eck Proc. Natl. Acad. Sci. U. S. A. 105 2008 2070
39. M.R. Patel, J. Jay-Dixon, A.A. Sadiq, B.A. Jacobson, and R.A. Kratzke J. Thorac. Oncol. 8 2013 1142
40. E. Buck, A. Eyzaguirre, J.D. Haley, N.W. Gibson, P. Cagnoni, and K.K. Iwata Mol. Cancer Ther. 5 2006 2051
41. T. Chou Cancer Res. 70 2010 440
42. E. Saxon, and C.R. Bertozzi Science 287 2000 2007
43. V.S. Gnanapragassam, K. Bork, C.E. Galuska, S.P. Galuska, D. Glanz, M. Nagasundaram, M. Bache, D. Vordermark, G. Kohla, C. Kannicht, R. Schauer, and R. Horstkorte PLoS ONE 9 2014 e105403
44. L.K. Mahal, K.J. Yarema, and C.R. Bertozzi Science 276 1997 1125
45. L.K. Mahal, K.J. Yarema, G.A. Lemieux, and C.R. Bertozzi Y. Inoue, Y.C. Lee, F.A. Troy II Sialobiology and Other Novel Forms of Glycosylation 1999 Gakushin Publishing Company Osaka, Japan 273 280