Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors

Journal of Medicinal Chemistry

Volumn 57, Issue 21, 2014, Pages 9096-9104

  Ghisaidoobe, Amar T ^a   Van Den Berg, Richard J B H N ^a   Butt, Saleem S ^a   Strijland, Anneke ^b   Donker Koopman, Wilma E ^b   Scheij, Saskia ^b   Van Den Nieuwendijk, Adrianus M C H ^a   Koomen, Gerrit Jan ^c   Van Loevezijn, Arnold ^c   Leemhuis, Mark ^c   Wennekes, Tom ^a,e   Van Der Stelt, Mario ^a   Van Der Marel, Gijsbert A ^a   Van Boeckel, Constant A A ^a,d,f   Aerts, Johannes M F G ^b   Overkleeft, Herman S ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d Pivot Park Screening Centre   (Netherlands)

^e WAGENINGEN UNIVERSITY   (Netherlands)

^f Albemarle Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXYNOJIRIMYCIN DERIVATIVE; ALPHA GLUCOSIDASE; ANTIDIABETIC AGENT; BENZYL DERIVATIVE; BETA GLUCOSIDASE; BETA GLUCOSIDASE 2; BIPHENYL DERIVATIVE; CERAMIDE GLUCOSYLTRANSFERASE INHIBITOR; GLUCOSIDASE 2 INHIBITOR; GLUCOSYLCERAMIDASE; GLUCOSYLCERAMIDASE 1; GLYCOSIDASE; IMINOSUGAR; INTESTINAL GLYCOSIDASE INHIBITOR; LACTASE; SUCRASE; UNCLASSIFIED DRUG; 1 DEOXYNOJIRIMYCIN; CERAMIDE GLUCOSYLTRANSFERASE; ENZYME INHIBITOR; GBA2 PROTEIN, HUMAN; GLUCOSYLTRANSFERASE;

ALKYLATION; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG SYNTHESIS; ENZYME INHIBITION; GAUCHER DISEASE; HUMAN; HYDROPHOBICITY; IC50; LIPID BLOOD LEVEL; LIPID METABOLISM; LYSOSOME STORAGE DISEASE; MOLECULAR SIZE; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATION; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMISTRY; SYNTHESIS;

1-DEOXYNOJIRIMYCIN; BETA-GLUCOSIDASE; BIPHENYL COMPOUNDS; ENZYME INHIBITORS; GLUCOSYLCERAMIDASE; GLUCOSYLTRANSFERASES; HUMANS; IMINO SUGARS;

EID: 84923831699     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501181z     Document Type: Article

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