Serotonin transporter polymorphism modifies the association between depressive symptoms and sleep onset latency complaint in elderly people: Results from the 'InveCe.Ab' study

Journal of Sleep Research

Volumn 24, Issue 2, 2015, Pages 215-222

  Polito, Letizia ^a   Davin, Annalisa ^a   Vaccaro, Roberta ^a   Abbondanza, Simona ^a   Govoni, Stefano ^a,b   Racchi, Marco ^a,b   Guaita, Antonio ^a  

^a Golgi Cenci Foundation   (Italy)

^b UNIVERSITY OF PAVIA   (Italy)

Author keywords

5 hydroxytryptamine; Aging; Antidepressants; Mood; SERT

Indexed keywords

GENOMIC DNA; SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, HUMAN;

AGED; ALLELE; ARTICLE; COGNITION; COMORBIDITY; DEPRESSION; FEMALE; GENOTYPE; GERIATRIC ASSESSMENT; GERIATRIC DEPRESSION SCALE; HEALTH; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL HEALTH; PITTSBURGH SLEEP QUALITY INDEX; PRIORITY JOURNAL; PROMOTER REGION; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SLEEP ONSET LATENCY; SLEEP PARAMETERS; SLEEP QUALITY; WAKEFULNESS; COMPLICATION; GENETIC POLYMORPHISM; GENETICS; SLEEP DISORDER; TIME;

AGED; ALLELES; DEPRESSION; FEMALE; HUMANS; MALE; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RISK FACTORS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SLEEP DISORDERS; TIME FACTORS;

EID: 84923802225     PISSN: 09621105     EISSN: 13652869     Source Type: Journal    
DOI: 10.1111/jsr.12248     Document Type: Article

References (38)

1. Almeida, O. P. and Pfaff, J. J. Sleep complaints among older general practice patients: association with depression. Br. J. Gen. Pract., 2005, 55: 864-866.
2. Barclay, N. L., Eley, T. C., Mill, J. et al. Sleep quality and diurnal preference in a sample of young adults: associations with 5HTTLPR, PER3, and CLOCK 3111. Am. J. Med. Genet. B Neuropsychiatr. Genet., 2011, 156B: 681-690.
3. Brummett, B. H., Krystal, A. D., Ashley-Koch, A. et al. Sleep quality varies as a function of 5-HTTLPR genotype and stress. Psychosom. Med., 2007, 69: 621-624.
4. Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R. and Kupfer, D. J. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res., 1989, 28: 193-213.
5. Carskadon, M. A., Sharkey, K. M., Knopik, V. S. and McGeary, J. E. Short sleep as an environmental exposure: a preliminary study associating 5-HTTLPR genotype to self-reported sleep duration and depressed mood in first-year university students. Sleep, 2012, 35: 791-796.
6. Cho, H. J., Lavretsky, H., Olmstead, R., Levin, M. J., Oxman, M. N. and Irwin, M. R. Sleep disturbance and depression recurrence in community-dwelling older adults: a prospective study. Am. J. Psychiatry, 2008, 165: 1543-1550.
7. Christiansen, L., Tan, Q., Iachina, M. et al. Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population. Biol. Psychiatry, 2007, 61: 223-230.
8. Clarke, H., Flint, J., Attwood, A. S. and Munafò, M. R. Association of the 5- HTTLPR genotype and unipolar depression: a meta-analysis. Psychol. Med., 2010, 40: 1767-1778.
9. Conwell, Y., Forbes, N. T., Cox, C. and Caine, E. D. Validation of a measure of physical illness burden at autopsy: the Cumulative Illness Rating Scale. J. Am. Geriatr. Soc., 1993, 41: 38-41.
10. Curcio, G., Tempesta, D., Scarlata, S. et al. Validity of the Italian version of the Pittsburgh Sleep Quality Index (PSQI). Neurol. Sci., 2013, 34: 511-519.
11. Deuschle, M., Schredl, M., Schilling, C. et al. Association between a serotonin transporter length polymorphism and primary insomnia. Sleep, 2010, 33: 343-347.
12. Fetveit, A. Late-life insomnia: a review. Geriatr. Gerontol. Int., 2009, 9: 220-234.
13. Gottlieb, D. J., Punjabi, N. M., Newman, A. B. et al. Association of sleep time with diabetes mellitus and impaired glucose tolerance. Arch. Intern. Med., 2005, 165: 863-867.
14. Guaita, A., Colombo, M., Vaccaro, R. et al. Brain aging and dementia during the transition from late adulthood to old age: design and methodology of the 'Invece.Ab' population-based study. BMC Geriatr., 2013, 13: 98.
15. Houdouin, F., Cespuglio, R. and Jouvet, M. Effects induced by the electrical stimulation of the nucleus raphe dorsalis upon hypothalamic release of 5-hydroxyindole compounds and sleep parameters in the rat. Brain Res., 1991, 565: 48-56.
16. Hu, X. Z., Lipsky, R. H., Zhu, G. et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am. J. Hum. Genet., 2006, 78: 815-826.
17. Isaia, G., Corsinovi, L., Bo, M. et al. Insomnia among hospitalized elderly patients: prevalence, clinical characteristics and risk factors. Arch Gerontol Geriatr., 2011, 52: 133-137.
18. Jouvet, M. Biogenic amines and the states of sleep. Science, 1969, 163: 32-41.
19. Katz, D. A. and McHorney, C. A. Clinical correlates of insomnia in patients with chronic illness. Arch. Intern. Med., 1998, 158: 1099-1107.
20. Landolt, H. P., Meier, V., Burgess, H. J. et al. Serotonin-2 receptors and human sleep: effect of a selective antagonist on EEG power spectra. Neuropsychopharmacology, 1999, 21: 455-466.
21. Mallik, S., Krumholz, H. M., Lin, Z. Q. et al. Patients with depressive symptoms have lower health status benefits after coronary artery bypass surgery. Circulation, 2005, 111: 271-277.
22. McCall, W. V. Sleep in the elderly: burden, diagnosis, and treatment. Prim. Care Companion J. Clin. Psychiatry, 2004, 6: 9-20.
23. McGinty, D. J. and Harper, R. M. Dorsal raphe neurons: depression of firing during sleep in cats. Brain Res., 1976, 101: 569-575.
24. Monti, J. M. Serotonin control of sleep-wake behavior. Sleep Med. Rev., 2011, 15: 269-281.
25. Monti, J. M. and Jantos, H. The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking. Prog. Brain Res., 2008, 172: 625-646.
26. Morairty, S. R., Hedley, L., Flores, J., Martin, R. and Kilduff, T. S. Selective 5HT2A and 5HT6 receptor antagonists promote sleep in rats. Sleep, 2008, 31: 34-44.
27. Nakamura, M., Ueno, S., Sano, A. and Tanabe, H. The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol. Psychiatry, 2000, 5: 32-38.
28. Pae, C. U., Jhoo, J. H., Yoon, I. Y. et al. Availability of brain serotonin transporters (5-HTT) is associated with low positive mood in healthy elderly subjects. Int. J. Clin. Pharmacol. Ther., 2012, 50: 533-539.
29. Portas, C. M., Bjorvatn, B., Fagerland, S. et al. On-line detection of extracellular levels of serotonin in dorsal raphe nucleus and frontal cortex over the sleep/wake cycle in the freely moving rat. Neuroscience, 1998, 83: 807-814.
30. Portas, C. M., Bjorvatn, B. and Ursin, R. Serotonin and the sleep/wake cycle: special emphasis on microdialysis studies. Prog. Neurobiol., 2000, 60: 13-35.
31. Python, A., Steimer, T., de Saint Hilaire, Z., Mikolajewski, R. and Nicolaidis, S. Extracellular serotonin variations during vigilance states in the preoptic area of rats: a microdialysis study. Brain Res., 2001, 910: 49-54.
32. Roepke, S. K. and Ancoli-Israel, S. Sleep disorders in the elderly. Indian J. Med. Res., 2010, 131: 302-310.
33. Sands-Lincoln, M., Loucks, E. B., Lu, B. et al. Sleep duration, insomnia, and coronary heart disease among postmenopausal women in the Women's Health Initiative. J. Womens Health, 2013, 22: 477-486.
34. Sillanpää, M. J. and Auranen, K. Replication in genetic studies of complex traits. Ann. Hum. Genet., 2004, 68: 646-657.
35. Thase, M. E. Correlates and consequences of chronic insomnia. Gen. Hosp. Psychiatry, 2005, 27: 100-112.
36. Wancata, J., Alexandrowicz, R., Marquart, B., Weiss, M. and Friedrich, F. The criterion validity of the Geriatric Depression Scale: a systematic review. Acta Psychiatr. Scand., 2006, 114: 398-410.
37. Wendland, J. R., Martin, B. J., Kruse, M. R., Lesch, K. P. and Murphy, D. L. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol. Psychiatry, 2006, 11: 224-226.
38. Zalsman, G., Huang, Y. Y., Oquendo, M. A. et al. Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am. J. Psychiatry, 2006, 163: 1588-1593.