Effects of nasal corticosteroids on boosts of systemic allergen-specific IgE production induced by nasal allergen exposure

PLoS ONE

Volumn 10, Issue 2, 2015, Pages

  Egger, Cornelia ^a   Lupinek, Christian ^a   Ristl, Robin ^b   Lemell, Patrick ^c   Horak, Friedrich ^c   Zieglmayer, Petra ^c   Spitzauer, Susanne ^b   Valenta, Rudolf ^a   Niederberger, Verena ^d  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c Allergy Centre Vienna West   (Austria)

^d UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; FLUTICASONE PROPIONATE; IMMUNOGLOBULIN A; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN M; PLACEBO; ANTIALLERGIC AGENT; CORTICOSTEROID; FLUTICASONE;

ADULT; ANTIGEN SPECIFICITY; ARTICLE; BIRCH; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DOUBLE BLIND PROCEDURE; EXPOSURE; FEMALE; GRASS POLLEN; HUMAN; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; MALE; NOSE PROVOCATION TEST; POLLEN ALLERGY; RANDOMIZED CONTROLLED TRIAL; RECOMMENDED DRUG DOSE; BLOOD; IMMUNOLOGY; INTRANASAL DRUG ADMINISTRATION; MIDDLE AGED; RHINITIS, ALLERGIC;

ADMINISTRATION, INTRANASAL; ADRENAL CORTEX HORMONES; ADULT; ANTI-ALLERGIC AGENTS; FEMALE; FLUTICASONE; HUMANS; IMMUNOGLOBULIN E; MALE; MIDDLE AGED; RHINITIS, ALLERGIC;

EID: 84923633972     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0114991     Document Type: Article

References (51)

1. Bischoff SC (2007) Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data. Nat Rev Immunol 7: 93-104. PMID: 17259966
2. van Neerven RJ, Knol EF, Ejrnaes A, Würtzen PA (2006) IgE-mediated allergen presentation and blocking antibodies: regulation of T-cell activation in allergy. Int Arch Allergy Immunol 141: 119-129. PMID: 16864979
3. Bieber T (1997) FcåRI-expressing antigen-presenting cells: new players in the atopic game. Immunol Today 18: 311-313. PMID: 9238831
4. Kawakami T, Galli SJ (2002) Regulation of mast-cell and basophil function and survival by IgE. Nat Rev Immunol 2: 773-786. PMID: 12360215
5. Saini SS, MacGlashan D (2002) How IgE upregulates the allergic response. Curr Opin Immunol 14: 694-697. PMID: 12413517
6. Gieras A, Focke-Tejkl M, Ball T, Verdino P, Hartl A, et al. (2007) Molecular determinants of allergen-induced effector cell degranulation. J Allergy Clin Immunol 119: 384-390. PMID: 17291855
7. Skov-Stahl P, Norh S, Weeke B (1977) Basophil histamine release in patients with hay fever. Results compared with specific IgE and total IgE during immunotherapy. Clin Exp Immunol 27: 432-439. PMID: 67913
8. Fennerty AG, Jones KP, Fifield R, Davies BH (1987) Challenge tests and specific IgE in hay fever sufferers. Clin Allergy 17: 365-372. PMID: 3621553
9. Southam DS, Ellis R, Wattie J, Inman MD (2007) Components of airway hyperresponsiveness and their associations with inflammation and remodelling in mice. J Allergy Clin Immunol 119: 848-854. PMID: 17321577
10. Dente FL, Bacci E, Di Franco A, Giannini D, Vagaggini B, et al. (2000) Natural exposure to pollen reduces the threshold but does not change the pattern of response to the allergen in allergic subjects. Respir Med 94: 1073-1078. PMID: 11127494
11. Niederberger V, Ring J, Rakoski J, Jäger S, Spitzauer S, et al. (2007) Antigens Drive Memory IgE Responses in Human Allergy via the Nasal Mucosa. Int Arch Allergy Immunol 142: 133-144. PMID: 17057411
12. Skamstrup Hansen K, Vieths S, Vestergaard H, Skov PS, Bindslev-Jensen C, et al. (2001) Seasonal variation in food allergy to apples. J Chromatogr B Biomed Sci Appl 756: 19-32. PMID: 11419712
13. Peroni DG, Boner AL, Vallone G, Antolini I, Warner JO (1994) Effective allergen avoidance at high altitude reduces allergen-induced bronchial hyperresponsiveness. Am J Respir Crit Care Med 149: 1442-1446. PMID: 8004296
14. Henderson LL, Larson JB, Gleich GJ (1975) Maximal rise in IgE antibody following ragweed pollination season. J Allergy Clin Immunol 55: 10-15. PMID: 45925
15. Naclerio RM, Adkinson NF Jr, Moylan B, Baroody FM, Proud D, et al. (1997) Nasal provocation with allergen induces a secondary serum IgE antibody response. J Allergy Clin Immunol 100: 505-510. PMID: 9338545
16. Mothes N, Heinzkill M, Drachenberg KJ, Sperr WR, Krauth MT, et al. (2003) Allergen-specific immunotherapy with a monophosphoryl lipid A-adjuvanted vaccine: reduced seasonally boosted immunoglobulin E production and inhibition of basophil histamine release by therapy-induced blocking antibodies. Clin Exp Allergy 33: 1198-1208. PMID: 12956739
17. Niederberger V, Horak F, Vrtala S, Spitzauer S, Krauth MT, et al. (2004) Vaccination with genetically engineered allergens prevents progression of allergic disease. Proc Natl Acad Sci U S A 101 Suppl 2: 14677-14682 PMID: 15310844
18. Creticos PS, Schroeder JT, Hamilton RG, Balcer-Whaley SL, Khattignavong AP, et al. (2006) Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis. N Engl J Med 355:1445-1455 PMID: 17021320
19. Gadermaier E, Staikuniene J, Scheiblhofer S, Thalhamer J, Kundi M (2011) Recombinant allergen-based monitoring of antibody responses during injection grass pollen immunotherapy and after 5 years of discontinuation. Allergy 66:1174-1182 doi: 10.1111/j.1398-9995.2011.02592.x PMID: 21480924
20. Hemady Z, Gellis S, Chambers M, Rocklin RE (1985) Effect of dexamethasone on de novo IgE synthesis by human blood lymphocytes. J Allergy Clin Immunol 75: 304-312. PMID: 3918092
21. Fischer A, König W (1990) Regulation of CD23 expression, soluble CD23 release and immunoglobulin synthesis of peripheral blood lymphocytes by glucocorticoids. Immunology 71: 473-479. PMID: 2149121
22. Bohle B, Willheim M, Baier K, Stadler B, Spitzauer S, et al. (1995) Hydrocortisone enhances total IgE levels - but not the synthesis of allergen- specific IgE - in a monocyte-dependent manner. Clin Exp Immunol 101: 474-479. PMID: 7664494
23. Cho YJ, Hong SJ, Moon HB (2000) Hydrocortisone enhances allergen-specific IgE production by peripheral blood mononuclear cells from atopic patients with high serum allergen-specific IgE levels. Clin Exp Allergy 30: 1576-1581. PMID: 11069566
24. Zieg G, Lack G, Harbeck RJ, Gelfand EW, Leung DY (1994) In vivo effects of glucocorticoids on IgE production. J Allergy Clin Immunol 94: 222-230. PMID: 8064074
25. Durham SR, Gould HJ, Thienes CP, Jacobson MR, Masuyama K, et al. (1997) Expression of epsilon germ-line gene transcripts and mRNA for the epsilon heavy chain of IgE in nasal B cells and the effects of topical corticosteroid. Eur J Immunol 27: 2899-2906. PMID: 9394816
26. Henderson LL, Larson JB, Gleich GJ (1973) Effect of corticosteroids on seasonal increases in IgE antibody. J Allergy Clin Immunol 52: 352. PMID: 4752933
27. Naclerio RM, Adkinson NF Jr, Creticos PS, Baroody FM, Hamilton RG, et al. (1993) Intranasal steroids inhibit seasonal increases in ragweed-specific immunoglobulin E antibodies. J Allergy Clin Immunol 92: 717-721. PMID: 8227863
28. Pullerits T, Praks L, Sjöstrand M, Rak S, Skoogh BE, et al. (1997) An intranasal glucocorticoid inhibits the increase of specific IgE initiated during birch pollen season. J Allergy Clin Immunol 100: 601-605. PMID: 9389288
29. Laffer S, Valenta R, Vrtala S, Susani M, van Ree R, et al. (1994) Complementary DNA cloning of the major allergen Phl p I from timothy grass (Phleum pratense); recombinant Phl p I inhibits IgE binding ot group I allergens from eight different grass species. J Allergy Clin Immunol 94: 689-698. PMID: 7930302
30. Vrtala S, Sperr WR, Reimitzer I, van Ree R, Laffer S, et al. (1993) cDNA cloning of a major allergen from timothy grass (Phleum pratense) pollen; characterization of the recombinant Phl p V allergen. J Immunol 151: 4773-4781. PMID: 7691956
31. Breiteneder H, Pettenburger K, Bito A, Valenta R, Kraft D, et al. (1989) The gene coding for the major birch pollen allergen Bet v 1, is highly homologous to a pea disease resistance response gene. EMBO J 8: 1935-1938. PMID: 2571499
32. Durham SR, Walker SM, Varga EM, Jacobson MR, O'Brien F (1999) Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med 341: 468-75. PMID: 10441602
33. Egger C, Horak F, Vrtala S, Valenta R, Niederberger V (2010) Nasal application of rBet v 1 or no-IgE-reactive T-cell epitope-containing rBet v 1 fragments has different effects on systemic allergen-specific antibody responses. J Allergy Clin Immunol 126:1312-1315. doi: 10.1016/j.jaci.2010.06.008 PMID: 20673979
34. Schäppi GF, Taylor PE, Pain MC, Cameron PA, Dent AW, et al. (1999) Concentrations of major grass group 5 allergens in pollen grains and atmospheric particles: implications for hay fever and allergic asthma sufferers sensitized to grass pollen allergens. Clin Exp Allergy 29: 633-641. PMID: 10231323
35. Andersson K, Lidholm J (2003) Characteristics and immunobiology of grass pollen allergens. Int Arch Allergy Immunol 130: 87-107. PMID: 12673063
36. Mösges R, Lehmacher W, Pasch N, Vent J (2009) Assessment of the antiobstructive effect of fexofenadine on nasal allergy challenge in patients with seasonal allergic rhinitis. Asian Pac J Allergy Immunol 27:181-90. PMID: 20232572
37. Hanf G, Noga O, O'Connor A, Kunkel G (2004) Omalizumab inhibits allergen challenge-induced nasal response. Eur Respir J 23:414-8. PMID: 15065831
38. Kawakami T, Galli SJ (2002) Regulation of mast-cell and basophil function and survival by IgE. Nat Rev Immmunol 2: 773-786. PMID: 12360215
39. Möller C, Dreborg S, Ferdousi HA, Halken S, Høst A, et al. (2002) Pollen immunotherapy reduces the development of asthma in children with seasonal rhinoconjunctivitis (the PAT-study). J Allergy Clin Immunol 109: 251-256 PMID: 11842293
40. Durham SR, Walker SM, Varga EM, Jacobson MR, O'Brien F, et al. (1999) Long-term clinical efficacy of grass-pollen immunotherapy. N Engl J Med 341: 468-475 PMID: 10441602
41. Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, et al. (2008) Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy 63 Suppl 86:8-160. doi: 10.1111/j.1398-9995.2007.01620.x PMID: 18331513
42. Fokkens W, Lund V, Bachert C, Clement P, Hellings P, et al. (2005) EAACI Position Paper on Rhinosinusits and Nasal Polyps Executive Summary. Allergy 60: 583-601. PMID: 15813802
43. Passalacqua G, Albano M, Canonica GW, Bachert C, Van Cauwenberge P, et al. (2000) Inhaled and nasal corticosteroids: safety aspects. Allergy 55:16-33. PMID: 10696853
44. Agertoft L, Pedersen S (1994) Effects of long-term treatment with an inhaled corticosteroid on growth and pulmonary function in asthmatic children. Respir Med 88: 373. PMID: 8036306
45. Haahtela T, Jarvinen M, Kava T, Kiviranta K, Koskinen S, et al. (1994) Effects of reducing or discontinuing inhaled budesonide in patients with mild asthma. N Engl J Med 331: 700. PMID: 8058076
46. Selroos O, Pietinalho A, Lofroos AB, Riska H (1995) Effect of early vs late intervention with inhaled corticosteoids in asthma. Chest 108: 1228. PMID: 7587421
47. Ferreira FD, Mayer P, Sperr WR, Valent P, Seiberler S, et al. (1996) Induction of IgE antibodies with predefined specificity in rhesus monkeys with recombinant birch pollen allergens, Bet v 1 and Bet v 2. J Allergy Clin Immunol 97: 95-103. PMID: 8568143
48. Durham SR, Gould HJ, Hamid QA (1997) Local IgE production in nasal allergy. Int Arch Allergy Immunol 113: 128-130 PMID: 9130501
49. Vrtala S, Ball T, Spitzauer S, Pandjaitan B, Suphioglu C, et al. (1998) Immunization with purified natural and recombinant allergens induces mouse IgG1 antibodies that recognize similar epitopes as human IgE and inhibit the human IgE-allergen interaction and allergen-induced basophil degranulation. J Immunol 15: 6137-6144.
50. Derendof H, Meltzer EO (2008) Molecular and clinical pharmacology of intranasal corticosteroids: clinical and therapeutic implications. Allergy 63: 1292-1300. doi: 10.1111/j.1398-9995.2008.01750.x PMID: 18782107
51. Rak S, Jacobson MR, Sudderick RM, Masuyama K, Juliusson S, et al. (2006) Influence of prolonged treatment with topical corticosteroid (fluticasone propionate) on early and late phase nasal responses and cellular infiltration in the nasal mucosa after allergen challenge. Clin Exp Allergy 24:930-939.