Imidazole-stabilized gold nanoparticles induce neuronal apoptosis: An in vitro and in vivo study

Journal of Biomedical Materials Research - Part A

Volumn 103, Issue 4, 2015, Pages 1436-1446

  Imperatore, Roberta ^a   Carotenuto, Gianfranco ^a   Di Grazia, Maria Antonietta ^a   Ferrandino, Ida ^b   Palomba, Letizia ^c   Mariotti, Raffaella ^d   Vitale, Emilia ^e   De Nicola, Sergio ^a   Longo, Angela ^a   Cristino, Luigia ^a  

^a CNR   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF URBINO   (Italy)

^d UNIVERSITY OF VERONA   (Italy)

^e INSTITUTE OF PROTEIN BIOCHEMISTRY   (Italy)

Author keywords

Apoptosis; Blood brain barrier; Cytotoxicity; Neuroblastoma; Thiolato ligands

Indexed keywords

ANIMAL CELL CULTURE; BIOLOGICAL MATERIALS; BLOOD; BRAIN; CELL CULTURE; CELL DEATH; CYTOTOXICITY; FIBER OPTIC SENSORS; GOLD; MAMMALS; METAL NANOPARTICLES; MOBILE SECURITY; NANOPARTICLES; SYNTHESIS (CHEMICAL); TOXICITY;

BIOLOGICAL APPLICATIONS; BIOLOGICAL STRUCTURES; BLOOD-BRAIN BARRIER; CELL CULTURE MEDIUMS; CHEMICAL INTERACTIONS; NEUROBLASTOMAS; OPTICAL AND ELECTRON MICROSCOPIES; THIOLATO LIGANDS;

NEURONS;

CASPASE 3; GOLD NANOPARTICLE; THIAMAZOLE; GOLD; IMIDAZOLE; IMIDAZOLE DERIVATIVE; METAL NANOPARTICLE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BRAIN REGION; CONTROLLED STUDY; CULTURE MEDIUM; DRUG ACCUMULATION; DRUG STABILITY; DRUG SYNTHESIS; ENDOSOME; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MALE; MOUSE; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROTOXICITY; NONHUMAN; PUTAMEN; ANIMAL; BRAIN; C57BL MOUSE; CELL SHAPE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENDOCYTOSIS; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; NERVE CELL; TIME; TISSUE DISTRIBUTION; TUNEL ASSAY; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; BRAIN; CELL SHAPE; ENDOCYTOSIS; GOLD; HUMANS; IMIDAZOLES; IN SITU NICK-END LABELING; INJECTIONS, INTRAVENOUS; METAL NANOPARTICLES; MICE, INBRED C57BL; NEURONS; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 84923589438     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.35289     Document Type: Article

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