Influence of indomethacin on ventilatory and cerebrovascular responsiveness to CO2 and breathing stability: The influence of PCO2 gradients

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 298, Issue 6, 2010, Pages

  Fan, Jui Lin ^a   Burgess, Keith R ^b   Thomas, Kate N ^a   Peebles, Karen C ^a   Lucas, Samuel J E ^a,c   Lucas, Rebekah A I ^a,c   Cotter, James D ^c   Ainslie, Philip N ^d  

^a UNIVERSITY OF OTAGO   (New Zealand)

^b UNIVERSITY OF SYDNEY   (Australia)

^c UNIVERSITY OF OTAGO   (New Zealand)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Cerebral blood flow; Rebreathing

Indexed keywords

CARBON DIOXIDE; INDOMETACIN;

ADULT; ARTERIAL BLOOD; ARTICLE; BLOOD GAS; BRAIN PERFUSION; BREATHING; CARBON DIOXIDE BREATHING; CONTROLLED STUDY; FEMALE; HUMAN; MALE; MIDDLE CEREBRAL ARTERY; NORMAL HUMAN; PRIORITY JOURNAL; REBREATHING; STEADY STATE;

ADULT; CARBON DIOXIDE; CYCLOOXYGENASE INHIBITORS; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; INDOMETHACIN; MALE; MIDDLE CEREBRAL ARTERY; OXYGEN; RESPIRATION; REST; WAKEFULNESS;

EID: 77952721522     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00721.2009     Document Type: Article

References (63)

1. Aaslid R, Markwalder TM, Nornes H. Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 57: 769-774, 1982. (Pubitemid 13208286)
2. Ainslie PN, Cotter JD, Dawson A, Fan JL, Lucas RA, Lucas SJE, Peebles KC, Bilson K, Swart M, Thomas KN, Burgess KR. Influence of cerebral blood flow on central sleep apnea at high altitude. International Hypoxia Symposium, Lake Louise, Alberta, Canada, March 10-13, 2009, p. 86.
3. 2 reactivity and chemoreflex control of breathing: mechanisms of regulation, measurement, and interpretation. Am J Physiol Regul Integr Comp Physiol 296: R1473-R1495, 2009.
4. Berkenbosch A, Bovill JG, Dahan A, DeGoede J, Olievier IC. The ventilatory CO2 sensitivities from Read's rebreathing method and the steady-state method are not equal in man. J Physiol 411: 367-377, 1989. (Pubitemid 19104541)
5. Bishop CC, Powell S, Rutt D, Browse NL. Transcranial Doppler measurement of middle cerebral artery blood flow velocity: a validation study. Stroke 17: 913-915, 1986. (Pubitemid 16000728)
6. Bruhn H, Fransson P, Frahm J. Modulation of cerebral blood oxygenation by indomethacin: MRI at rest and functional brain activation. J Magn Reson Imaging 13: 325-334, 2001. (Pubitemid 32173397)
7. Burgess K, Fan JL, Peebles KC, Thomas K, Lucas S, Lucas RA, Dawson A, Swart M, Shepherd K, Ainslie P. Exacerbation of obstructive sleep apnea by oral indomethacin. Chest. In press.
8. Chapman KR, Bruce EN, Gothe B, Cherniack NS. Possible mechanisms of periodic breathing during sleep. J Appl Physiol 64: 1000-1008, 1988.
9. Chapman RW, Santiago TV, Edelman NH. Effects of graded reduction of brain blood flow on chemical control of breathing. J Appl Physiol 47: 1289-1294, 1979.
10. Cherniack NS, Longobardo GS. Cheyne-Stokes breathing. An instability in physiologic control. N Engl J Med 288: 952-957, 1973.
11. Claassen JA, Zhang R, Fu Q, Witkowski S, Levine BD. Transcranial Doppler estimation of cerebral blood flow and cerebrovascular conductance during modified rebreathing. J Appl Physiol 102: 870-877, 2007. (Pubitemid 46377007)
12. Cummin AR, Jacobi MS, Patil CP, Telford RJ, Morgan CN, Saunders KB. The effect of almitrine on the steady-state ventilatory response to carbon dioxide at rest and during exercise in man. Eur Respir J 3: 693-698, 1990.
13. 2 in man. Ann NY Acad Sci 109: 756-771, 1963.
14. Daskalopoulou E, Patakas D, Tsara V, Zoglopitis F, Maniki E. Comparison of almitrine bismesylate and medroxyprogesterone acetate on oxygenation during wakefulness and sleep in patients with chronic obstructive lung disease. Thorax 45: 666-669, 1990. (Pubitemid 20328040)
15. Dempsey JA. Crossing the apnoeic threshold: causes and consequences. Exp Physiol 90: 13-24, 2005.
16. Duffin J, Mohan RM, Vasiliou P, Stephenson R, Mahamed S. A model of the chemoreflex control of breathing in humans: model parameters measurement. Respir Physiol 120: 13-26, 2000. (Pubitemid 30154040)
17. Eriksson S, Hagenfeldt L, Law D, Patrono C, Pinca E, Wennmalm A. Effect of prostaglandin synthesis inhibitors on basal and carbon dioxide stimulated cerebral blood flow in man. Acta Physiol Scand 117: 203-211, 1983. (Pubitemid 13121034)
18. Feleky A. The influence of the emotions on respiration. J Exp Psychol 1: 218-241, 1916.
19. Fink BR. Influence of cerebral activity in wakefulness on regulation of breathing. J Appl Physiol 16: 15-20, 1961.
20. Gardner WN. The pattern of breathing following step changes of alveolar partial pressures of carbon dioxide and oxygen in man. J Physiol 300: 55-73, 1980.
21. Giannoni A, Emdin M, Poletti R, Bramanti F, Prontera C, Piepoli M, Passino C. Clinical significance of chemosensitivity in chronic heart failure: influence on neurohormonal derangement, Cheyne-Stokes respiration and arrhythmias. Clin Sci (Lond) 114: 489-497, 2008. (Pubitemid 351548757)
22. 3H]catecholamine release. J Physiol 476: 257-267, 1994.
23. Gomez-Nino A, Almaraz L, Gonzalez C. Potentiation by cyclooxygenase inhibitors of the release of catecholamines from the rabbit carotid body and its reversal by prostaglandin E2. Neurosci Lett 140: 1-4, 1992.
24. Grassi B, Ferretti G, Costa M, Ferrigno M, Panzacchi A, Lundgren CE, Marconi C, Cerretelli P. Ventilatory responses to hypercapnia and hypoxia in elite breath-hold divers. Respir Physiol 97: 323-332, 1994. (Pubitemid 24229193)
25. Green RS, Leffler CW, Busija DW, Fletcher AM, Beasley DG. Indomethacin does not alter the circulating catecholamine response to asphyxia in the neonatal piglet. Pediatr Res 21: 534-537, 1987.
26. Hohimer AR, Richardson BS, Bissonnette JM, Machida CM. The effect of indomethacin on breathing movements and cerebral blood flow and metabolism in the fetal sheep. J Dev Physiol 7: 217-228, 1985. (Pubitemid 15225668)
27. Holloway W, McNally RJ. Effects of anxiety sensitivity on the response to hyperventilation. J Abnorm Psychol 96: 330-334, 1987.
28. Honda Y, Tani H. Chemical control of breathing. In: Control of Breathing in Health and Disease, edited by Altose MD and Kawakami Y. New York: Dekker, 1999, p. 41-87.
29. Ivancev V, Bakovic D, Obad A, Breskovic T, Palada I, Joyner MJ, Dujic Z. Effects of indomethacin on cerebrovascular response to hypercapnea and hypocapnea in breath-hold diving and obstructive sleep apnea. Respir Physiol Neurobiol 166: 152-158, 2009.
30. Jacobi MS, Patil CP, Saunders KB. Transient, steady-state and rebreathing responses to carbon dioxide in man, at rest and during light exercise. J Physiol 411: 85-96, 1989. (Pubitemid 19104525)
31. Jansen AH, De Boeck C, Ioffe S, Chernick V. Indomethacin-induced fetal breathing: mechanism and site of action. J Appl Physiol 57: 360-365, 1984. (Pubitemid 14043186)
32. Javaheri S. A mechanism of central sleep apnea in patients with heart failure. N Engl J Med 341: 949-954, 1999. (Pubitemid 29441549)
33. Jensen K, Kjaergaard S, Malte E, Bunemann L, Therkelsen K, Knudsen F. Effect of graduated intravenous and standard rectal doses of indomethacin on cerebral blood flow in healthy volunteers. J Neurosurg Anesthesiol 8: 111-116, 1996. (Pubitemid 26099786)
34. Khoo MC, Kronauer RE, Strohl KP, Slutsky AS. Factors inducing periodic breathing in humans: a general model. J Appl Physiol 53: 644-659, 1982.
35. Kraaier V, Van Huffelen AC, Wieneke GH, Van der Worp HB, Bar PR. Quantitative EEG changes due to cerebral vasoconstriction. Indomethacin versus hyperventilation-induced reduction in cerebral blood flow in normal subjects. Electroencephalogr Clin Neurophysiol 82: 208-212, 1992.
36. Markus HS, Vallance P, Brown MM. Differential effect of three cyclo-oxygenase inhibitors on human cerebral blood flow velocity and carbon dioxide reactivity. Stroke 25: 1760-1764, 1994. (Pubitemid 24274968)
37. McQueen DS, Belmonte C. The effects of prostaglandins E2, A2 and F2α on carotid baroreceptors and chemoreceptors. Q J Exp Physiol Cogn Med Sci 59: 63-71, 1974.
38. Mohan R, Duffin J. The effect of hypoxia on the ventilatory response to carbon dioxide in man. Respir Physiol 108: 101-115, 1997. (Pubitemid 27276199)
39. Mohan RM, Amara CE, Cunningham DA, Duffin J. Measuring central-chemoreflex sensitivity in man: rebreathing and steady-state methods compared. Respir Physiol 115: 23-33, 1999. (Pubitemid 29150330)
40. Nuttall GA, Cook DJ, Fulgham Jr, Oliver WC Jr, Proper JA. The relationship between cerebral blood flow and transcranial Doppler blood flow velocity during hypothermic cardiopulmonary bypass in adults. Anesth Analg 82: 1146-1151, 1996. (Pubitemid 26157993)
41. 2 measured with steady-state and modified rebreathing methods. Respir Physiol Neurobiol 159: 34-44, 2007.
42. 2 with the steady-state method and Read's rebreathing method. Adv Exp Med Biol 499: 279-284, 2001.
43. 2 measured with steady-state and Read's rebreathing methods. Respir Physiol Neurobiol 137: 1-10, 2003.
44. 2. J Physiol 584: 347-357, 2007.
45. Peebles KC, Richards AM, Celi L, McGrattan K, Murrell CJ, Ainslie PN. Human cerebral arteriovenous vasoactive exchange during alterations in arterial blood gases. J Appl Physiol 105: 1060-1068, 2008.
46. Pinna GD, Maestri R, Mortara A, La Rovere MT, Fanfulla F, Sleight P. Periodic breathing in heart failure patients: testing the hypothesis of instability of the chemoreflex loop. J Appl Physiol 89: 2147-2157, 2000.
47. Pourcyrous M, Leffler CW, Bada HS, Korones SB, Busija DW. Cerebral blood flow responses to indomethacin in awake newborn pigs. Pediatr Res 35: 565-570, 1994. (Pubitemid 24130114)
48. Read DJ. A clinical method for assessing the ventilatory response to carbon dioxide. Australas Ann Med 16: 20-32, 1967.
49. Reichmuth KJ, Dopp JM, Barczi SR, Skatrud JB, Wojdyla P, Hayes D Jr, Morgan BJ. Impaired vascular regulation in patients with obstructive sleep apnea: effects of CPAP treatment. Am J Respir Crit Care Med 180: 1143-1150, 2009.
50. Serrador JM, Picot PA, Rutt BK, Shoemaker JK, Bondar RL. MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. Stroke 31: 1672-1678, 2000.
51. 2 in unanesthetized intact dogs: central vs. peripheral chemoreceptors. J Appl Physiol 100: 13-19, 2006.
52. Solin P, Roebuck T, Johns DP, Walters EH, Naughton MT. Peripheral and central ventilatory responses in central sleep apnea with and without congestive heart failure. Am J Respir Crit Care Med 162: 2194-2200, 2000. (Pubitemid 32051686)
53. St Lawrence KS, Ye FQ, Lewis BK, Weinberger DR, Frank JA, McLaughlin AC. Effects of indomethacin on cerebral blood flow at rest and during hypercapnia: an arterial spin tagging study in humans. J Magn Reson Imaging 15: 628-635, 2002.
54. Staessen J, Cattaert A, Fagard R, Lijnen P, Moerman E, De Schaepdryver A, Amery A. Hemodynamic and humoral effects of prostaglandin inhibition in exercising humans. J Appl Physiol 56: 39-45, 1984.
55. 2 and hypoxic stimuli on ventilation at high altitude. Q J Exp Physiol Cogn Med Sci 48: 192-201, 1963.
56. 2 variations in patients with severe closed head injury: comparison between the Fick and transcranial Doppler methods. J Neurosurg 88: 996-1001, 1998.
57. Valdueza JM, Balzer JO, Villringer A, Vogl TJ, Kutter R, Einhaupl KM. Changes in blood flow velocity and diameter of the middle cerebral artery during hyperventilation: assessment with MR and transcranial Doppler sonography. AJNR Am J Neuroradiol 18: 1929-1934, 1997.
58. Wennmalm A, Carlsson I, Edlund A, Eriksson S, Kaijser L, Nowak J. Central and peripheral haemodynamic effects of non-steroidal anti-inflammatory drugs in man. Arch Toxicol Suppl 7: 350-359, 1984.
59. Wennmalm A, Eriksson S, Hagenfeldt L, Law D, Patrono C, Pinca E. Effect of prostaglandin synthesis inhibitors on basal and carbon dioxide-stimulated cerebral blood flow in man. Adv Prostaglandin Thromboxane Leukot Res 12: 351-355, 1983.
60. Xie A, Skatrud JB, Barczi SR, Reichmuth K, Morgan BJ, Mont S, Dempsey JA. Influence of cerebral blood flow on breathing stability. J Appl Physiol 106: 850-856, 2009.
61. Xie A, Skatrud JB, Khayat R, Dempsey JA, Morgan B, Russell D. Cerebrovascular response to carbon dioxide in patients with congestive heart failure. Am J Respir Crit Care Med 172: 371-378, 2005. (Pubitemid 41026149)
62. Xie A, Skatrud JB, Morgan B, Chenuel B, Khayat R, Reichmuth K, Lin J, Dempsey JA. Influence of cerebrovascular function on the hypercapnic ventilatory response in healthy humans. J Physiol 577: 319-329, 2006. (Pubitemid 44698258)
63. 2 on the susceptibility to posthyperventilation apnea during sleep. J Appl Physiol 100: 171-177, 2006.