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Volumn , Issue 96, 2015, Pages

Generation of CAR T cells for adoptive therapy in the context of glioblastoma standard of care

Author keywords

Adoptive transfer; Chimeric antigen receptor; Glioblastoma; Immunology; Issue 96; Radiotherapy; Temozolomide; Tumor immunotherapy

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR VIII; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 84923553822     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/52397     Document Type: Article
Times cited : (20)

References (37)
  • 1
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp, R., et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 352, (10), 987-996 (2005).
    • (2005) N Engl J Med , vol.352 , Issue.10 , pp. 987-996
    • Stupp, R.1
  • 2
    • 77955066199 scopus 로고    scopus 로고
    • Sipuleucel-T immunotherapy for castration-resistant prostate cancer
    • Kantoff, P., Higano, C., Shore, N., Berger, E., Small, E. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N Engl J Med. (363), 411-422 (2010).
    • (2010) N Engl J Med , Issue.363 , pp. 411-422
    • Kantoff, P.1    Higano, C.2    Shore, N.3    Berger, E.4    Small, E.5
  • 3
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi, F. S., et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 363, (8), 711-723 (2010).
    • (2010) N Engl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1
  • 4
    • 79957831345 scopus 로고    scopus 로고
    • Gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma
    • Schwartzentruber, D. J., et al. gp100 peptide vaccine and interleukin-2 in patients with advanced melanoma. N Engl J Med. 364, (22), 2119-2127 (2011).
    • (2011) N Engl J Med , vol.364 , Issue.22 , pp. 2119-2127
    • Schwartzentruber, D.J.1
  • 5
    • 0024580836 scopus 로고
    • Generation of effector T cells expressing chimeric T cell receptor with antibody type-specificity
    • Gross, G., Gorochov, G., Waks, T., Eshhar, Z. Generation of effector T cells expressing chimeric T cell receptor with antibody type-specificity. Transplant Proc. 21, (1 Pt 1), 127-130 (1989).
    • (1989) Transplant Proc , vol.21 , Issue.1 , pp. 127-130
    • Gross, G.1    Gorochov, G.2    Waks, T.3    Eshhar, Z.4
  • 6
    • 55549145071 scopus 로고    scopus 로고
    • Virus-specific T cells engineered to coexpress tumor-specific receptors: Persistence and antitumor activity in individuals with neuroblastoma
    • Pule, M. A., et al. Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma. Nat Med. 14, (11), 1264-1270 (2008).
    • (2008) Nat Med , vol.14 , Issue.11 , pp. 1264-1270
    • Pule, M.A.1
  • 7
    • 84863337890 scopus 로고    scopus 로고
    • B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells
    • Kochenderfer, J. N., et al. B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells. Blood. 119, (12), 2709-2720 (2012).
    • (2012) Blood , vol.119 , Issue.12 , pp. 2709-2720
    • Kochenderfer, J.N.1
  • 8
    • 80051720194 scopus 로고    scopus 로고
    • Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia
    • Porter, D. L., Levine, B. L., Kalos, M., Bagg, A., June, C. H. Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia. N Engl J Med. 365, (8), 725-733 (2011).
    • (2011) N Engl J Med , vol.365 , Issue.8 , pp. 725-733
    • Porter, D.L.1    Levine, B.L.2    Kalos, M.3    Bagg, A.4    June, C.H.5
  • 9
    • 80455179612 scopus 로고    scopus 로고
    • Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias
    • Brentjens, R. J., et al. Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood. 118, (18), 4817-4828 (2011).
    • (2011) Blood , vol.118 , Issue.18 , pp. 4817-4828
    • Brentjens, R.J.1
  • 10
    • 0029025332 scopus 로고
    • Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas
    • Wikstrand, C. J., et al. Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas. Cancer Res. 55, (14), 3140-3148 (1995).
    • (1995) Cancer Res , vol.55 , Issue.14 , pp. 3140-3148
    • Wikstrand, C.J.1
  • 11
    • 84896734231 scopus 로고    scopus 로고
    • EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss
    • Sampson, J. H., et al. EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss. Clin Cancer Res. 20, (4), 972-984 (2014).
    • (2014) Clin Cancer Res , vol.20 , Issue.4 , pp. 972-984
    • Sampson, J.H.1
  • 12
    • 0024392891 scopus 로고
    • Inhibition of lymphocyte function by glioblastoma-derived transforming growth factor beta 2
    • Kuppner, M. C., Hamou, M. F., Sawamura, Y., Bodmer, S., de Tribolet, N. Inhibition of lymphocyte function by glioblastoma-derived transforming growth factor beta 2. J Neurosurg. 71, (2), 211-217 (1989).
    • (1989) J Neurosurg , vol.71 , Issue.2 , pp. 211-217
    • Kuppner, M.C.1    Hamou, M.F.2    Sawamura, Y.3    Bodmer, S.4    De Tribolet, N.5
  • 13
    • 0242442492 scopus 로고    scopus 로고
    • Expression of the B7-related molecule B7-H1 by glioma cells: A potential mechanism of immune paralysis
    • Wintterle, S., et al. Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis. Cancer Res. 63, (21), 7462-7467 (2003).
    • (2003) Cancer Res , vol.63 , Issue.21 , pp. 7462-7467
    • Wintterle, S.1
  • 14
    • 33645502885 scopus 로고    scopus 로고
    • Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma
    • Fecci, P. E., et al. Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma. Cancer Res. 66, (6), 3294-3302 (2006).
    • (2006) Cancer Res , vol.66 , Issue.6 , pp. 3294-3302
    • Fecci, P.E.1
  • 15
    • 22544486023 scopus 로고    scopus 로고
    • B7-homolog 1 expression by human glioma: A new mechanism of immune evasion
    • Wilmotte, R., et al. B7-homolog 1 expression by human glioma: a new mechanism of immune evasion. Neuroreport. 16, (10), 1081-1085 (2005).
    • (2005) Neuroreport , vol.16 , Issue.10 , pp. 1081-1085
    • Wilmotte, R.1
  • 16
    • 0141923794 scopus 로고    scopus 로고
    • Mediation of enhanced transcription of the IL-10 gene in T cells, upon contact with human glioma cells, by fas signaling through a protein kinase A-independent pathway
    • Yang, B. C., et al. Mediation of enhanced transcription of the IL-10 gene in T cells, upon contact with human glioma cells, by fas signaling through a protein kinase A-independent pathway. Journal of Immunology. 171, (8), 3947-3954 (2003).
    • (2003) Journal of Immunology , vol.171 , Issue.8 , pp. 3947-3954
    • Yang, B.C.1
  • 17
    • 0027172819 scopus 로고
    • Temozolomide: A new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours
    • Reilly, S. M., et al. Temozolomide: a new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours. Eur J Cancer. 29A, (7), 940-942 (1993).
    • (1993) Eur J Cancer , vol.29 , Issue.7 , pp. 940-942
    • Reilly, S.M.1
  • 18
    • 33748085015 scopus 로고    scopus 로고
    • The Combination of Ionizing Radiation and Peripheral Vaccination Produces Long-term Survival of Mice Bearing Established Invasive GL261Gliomas
    • Newcomb, E., et al. The Combination of Ionizing Radiation and Peripheral Vaccination Produces Long-term Survival of Mice Bearing Established Invasive GL261Gliomas. Clin Cancer Res. 12, 4730-4737 (2006).
    • (2006) Clin Cancer Res , vol.12 , pp. 4730-4737
    • Newcomb, E.1
  • 19
    • 84892412579 scopus 로고    scopus 로고
    • The effect of radiation on the immune response to cancers
    • Park, B., Yee, C., Lee, K. M. The effect of radiation on the immune response to cancers. Int J Mol Sci. 15, (1), 927-943 (2014).
    • (2014) Int J Mol Sci , vol.15 , Issue.1 , pp. 927-943
    • Park, B.1    Yee, C.2    Lee, K.M.3
  • 20
    • 84883445769 scopus 로고    scopus 로고
    • Intratumoral temozolomide synergizes with immunotherapy in a T cell-dependent fashion
    • Fritzell, S., et al. Intratumoral temozolomide synergizes with immunotherapy in a T cell-dependent fashion. Cancer Immunol Immunother. 62, (9), 1463-1474 (2013).
    • (2013) Cancer Immunol Immunother , vol.62 , Issue.9 , pp. 1463-1474
    • Fritzell, S.1
  • 21
    • 34047181668 scopus 로고    scopus 로고
    • Cross-priming by temozolomide enhances antitumor immunity of dendritic cell vaccination in murine brain tumor model
    • Park, S. D., et al. Cross-priming by temozolomide enhances antitumor immunity of dendritic cell vaccination in murine brain tumor model. Vaccine. 25, (17), 3485-3491 (2007).
    • (2007) Vaccine , vol.25 , Issue.17 , pp. 3485-3491
    • Park, S.D.1
  • 22
    • 24944478531 scopus 로고    scopus 로고
    • Leveraging the activity of tumor vaccines with cytotoxic chemotherapy
    • Emens, L. A., Jaffee, E. M. Leveraging the activity of tumor vaccines with cytotoxic chemotherapy. Cancer Res. 65, (18), 8059-8064 (2005).
    • (2005) Cancer Res , vol.65 , Issue.18 , pp. 8059-8064
    • Emens, L.A.1    Jaffee, E.M.2
  • 23
    • 84865730752 scopus 로고    scopus 로고
    • An in vivo immunotherapy screen of costimulatory molecules identifies Fc-OX40L as a potent reagent for the treatment of established murine gliomas
    • Murphy, K. A., et al. An in vivo immunotherapy screen of costimulatory molecules identifies Fc-OX40L as a potent reagent for the treatment of established murine gliomas. Clin Cancer Res. 18, (17), 4657-4668 (2012).
    • (2012) Clin Cancer Res , vol.18 , Issue.17 , pp. 4657-4668
    • Murphy, K.A.1
  • 24
    • 77950221339 scopus 로고    scopus 로고
    • Radiotherapy enhances antitumor effect of anti-CD137 therapy in a mouse Glioma model
    • Newcomb, E. W., et al. Radiotherapy enhances antitumor effect of anti-CD137 therapy in a mouse Glioma model. Radiat Res. 173, (4), 426-432 (2010).
    • (2010) Radiat Res , vol.173 , Issue.4 , pp. 426-432
    • Newcomb, E.W.1
  • 25
    • 23044508156 scopus 로고    scopus 로고
    • How lymphotoxic is dose-intensified temozolomide? The glioblastoma experience
    • Su, Y. B., Krown, S. E., Livingston, P. O., Wolchok, J. D., Chapman, P. B. How lymphotoxic is dose-intensified temozolomide? The glioblastoma experience. J Clin Oncol. 23, (18), 4235-4236 (2005).
    • (2005) J Clin Oncol , vol.23 , Issue.18 , pp. 4235-4236
    • Su, Y.B.1    Krown, S.E.2    Livingston, P.O.3    Wolchok, J.D.4    Chapman, P.B.5
  • 26
    • 77953983710 scopus 로고    scopus 로고
    • Dose-dense temozolomide regimens: Antitumor activity, toxicity, and immunomodulatory effects
    • Neyns, B., Tosoni, A., Hwu, W. J., Reardon, D. A. Dose-dense temozolomide regimens: antitumor activity, toxicity, and immunomodulatory effects. Cancer. 116, (12), 2868-2877 (2010).
    • (2010) Cancer , vol.116 , Issue.12 , pp. 2868-2877
    • Neyns, B.1    Tosoni, A.2    Hwu, W.J.3    Reardon, D.A.4
  • 27
    • 33751564865 scopus 로고    scopus 로고
    • Increased intensity lymphodepletion and adoptive immunotherapy-how far can we go
    • Muranski, P., et al. Increased intensity lymphodepletion and adoptive immunotherapy-how far can we go. Nat Clin Pract Oncol. 3, (12), 668-681 (2007).
    • (2007) Nat Clin Pract Oncol , vol.3 , Issue.12 , pp. 668-681
    • Muranski, P.1
  • 28
    • 14844302392 scopus 로고    scopus 로고
    • Less is more: Lymphodepletion followed by hematopoietic stem cell transplant augments adoptive T-cell-based anti-tumor immunotherapy
    • Wrzesinski, C., Restifo, N. P. Less is more: lymphodepletion followed by hematopoietic stem cell transplant augments adoptive T-cell-based anti-tumor immunotherapy. Current Opinion in Immunology. 17, (2), 195-201 (2005).
    • (2005) Current Opinion in Immunology , vol.17 , Issue.2 , pp. 195-201
    • Wrzesinski, C.1    Restifo, N.P.2
  • 29
    • 55949125601 scopus 로고    scopus 로고
    • Adoptive cell therapy for patients with metastatic melanoma: Evaluation of intensive myeloablative chemoradiation preparative regimens
    • Dudley, M. E., et al. Adoptive cell therapy for patients with metastatic melanoma: evaluation of intensive myeloablative chemoradiation preparative regimens. J Clin Oncol. 26, (32), 5233-5239 (2008).
    • (2008) J Clin Oncol , vol.26 , Issue.32 , pp. 5233-5239
    • Dudley, M.E.1
  • 30
    • 84875068031 scopus 로고    scopus 로고
    • Myeloablative Temozolomide Enhances CD8(+) T-Cell Responses to Vaccine and Is Required for Efficacy against Brain Tumors in Mice
    • Sanchez-Perez, L. A., et al. Myeloablative Temozolomide Enhances CD8(+) T-Cell Responses to Vaccine and Is Required for Efficacy against Brain Tumors in Mice. Plos One. 8, (3), (2013).
    • (2013) Plos One , vol.8 , Issue.3
    • Sanchez-Perez, L.A.1
  • 31
    • 1442283179 scopus 로고    scopus 로고
    • Selective CD4+ lymphopenia in melanoma patients treated with temozolomide: A toxicity with therapeutic implications
    • Su, Y. B., et al. Selective CD4+ lymphopenia in melanoma patients treated with temozolomide: a toxicity with therapeutic implications. J Clin Oncol. 22, (4), 610-616 (1200).
    • J Clin Oncol , vol.22 , Issue.4 , pp. 610-616
    • Su, Y.B.1
  • 32
    • 0036076114 scopus 로고    scopus 로고
    • T cell homeostatic proliferation elicits effective antitumor autoimmunity
    • Dummer, W., et al. T cell homeostatic proliferation elicits effective antitumor autoimmunity. J Clin Invest. 110, (2), 185-192 (2002).
    • (2002) J Clin Invest , vol.110 , Issue.2 , pp. 185-192
    • Dummer, W.1
  • 33
    • 25844484607 scopus 로고    scopus 로고
    • Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells
    • Gattinoni, L., et al. Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells. J Exp Med. 202, (7), 907-912 (2005).
    • (2005) J Exp Med , vol.202 , Issue.7 , pp. 907-912
    • Gattinoni, L.1
  • 34
    • 74349084455 scopus 로고    scopus 로고
    • Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells
    • Wrzesinski, C., et al. Increased intensity lymphodepletion enhances tumor treatment efficacy of adoptively transferred tumor-specific T cells. J Immunother. 33, (1), 1-7 (2010).
    • (2010) J Immunother , vol.33 , Issue.1 , pp. 1-7
    • Wrzesinski, C.1
  • 35
    • 20844448391 scopus 로고    scopus 로고
    • Transfer of a TCR gene derived from a patient with a marked antitumor response conveys highly active T-cell effector functions
    • Hughes, M. S., et al. Transfer of a TCR gene derived from a patient with a marked antitumor response conveys highly active T-cell effector functions. Hum Gene Ther. 16, (4), 457-472 (2005).
    • (2005) Hum Gene Ther , vol.16 , Issue.4 , pp. 457-472
    • Hughes, M.S.1
  • 36
    • 84875198775 scopus 로고    scopus 로고
    • Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma
    • Morgan, R. A., et al. Recognition of glioma stem cells by genetically modified T cells targeting EGFRvIII and development of adoptive cell therapy for glioma. Hum Gene Ther. 23, (10), 1043-1053 (2012).
    • (2012) Hum Gene Ther , vol.23 , Issue.10 , pp. 1043-1053
    • Morgan, R.A.1
  • 37
    • 79955610422 scopus 로고    scopus 로고
    • Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies
    • Kerkar, S. P., et al. Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies. J Immunother. 34, (4), 343-352 (2011).
    • (2011) J Immunother , vol.34 , Issue.4 , pp. 343-352
    • Kerkar, S.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.