Safety evaluation of metal exposure from commonly used moisturizing and skin-lightening creams in Nigeria

Regulatory Toxicology and Pharmacology

Volumn 71, Issue 3, 2015, Pages 484-490

  Iwegbue, Chukwujindu M A ^a,d   Bassey, Francisca I ^b   Tesi, Godswill O ^a   Onyeloni, Sunday O ^a   Obi, Grace ^c   Martincigh, Bice S ^d  

^a DELTA STATE UNIVERSITY   (Nigeria)

^b UNIVERSITY OF CALABAR   (Nigeria)

^c Department of Petroleum and Gas Engineering Federal   (Nigeria)

^d UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Body creams; Contact dermatitis; Exposure; Metals; Nigeria

Indexed keywords

ALUMINUM; CADMIUM; CHROMIUM; COBALT; COPPER; COSMETIC; DEPIGMENTING AGENT; HEAVY METAL; IRON; LEAD; MANGANESE; NICKEL; ZINC; METAL; SKIN CREAM;

ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; CONTROLLED STUDY; CREAM; ENVIRONMENTAL EXPOSURE; LIMIT OF DETECTION; LIMIT OF QUANTITATION; NIGERIA; PRIORITY JOURNAL; PRODUCT RECOVERY; RISK ASSESSMENT; DERMATITIS, CONTACT; HUMAN; RISK FACTOR;

DERMATITIS, CONTACT; HUMANS; METALS; NIGERIA; RISK ASSESSMENT; RISK FACTORS; SKIN CREAM; SKIN LIGHTENING PREPARATIONS; SPECTROPHOTOMETRY, ATOMIC;

EID: 84923546170     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2015.01.015     Document Type: Article

References (48)

1. Ababneh F.A., Abu-Sbeih K.A., Al-Momani I.F. Evaluation of allergenic metals and other trace elements in personal care products. Jordan J. Chem. 2013, 8(3):179-190.
2. Alqadami A.A., Abdalla M.A., Al Othman Z.A., Omer K. Application of solid phase extraction on the multi walled carbon nanotubes of some heavy metal ions to analysis of skin whitening cosmetics using ICP-AES. Int. J. Environ. Res. Public Health 2013, 10:361-374.
3. Al-Saleh I., Al-Enazi S. Trace metals in lipsticks. Toxicol. Environ. Chem. 2011, 93(6):1149-1165.
4. Ayenimo J.G., Yusuf A.M., Adekunle A.S., Makinde O.W. Heavy metal exposure from personal care products. Bull. Environ. Contam. Toxicol. 2010, 84:8-14.
5. Baruthio F. Toxic effects of chromium and its compounds. Biol. Trace Elem. Res. 1992, 32:145-153.
6. Basketter D.A., Angelini G., Ingber A., Kern P.S., Menné T. Nickel, chromium and cobalt in consumer products: revisiting safe levels in the new millennium. Contact Dermatitis 2003, 49:1-7.
7. Bellinger D.C. Teratogen update: lead and pregnancy. Birth Defects Res. A Clin. Mol. Teratol. 2005, 73:409-420.
8. Bocca B., Forte G., Petrucci F., Cristaudo A. Levels of nickel and other potentially allergenic metals in Ni-tested commercial body creams. J. Pharm. Biomed. Anal. 2007, 44:1197-1202.
9. Contado C., Pagnoni A. A new strategy for pressed powder eye shadow analysis: allergenic metal ion content and particle size distribution. Sci. Total Environ. 2012, 432:173-179.
10. Dalmazio, I., Menezes, M.A.deB.C., 2011. Multi-element profile of some Brazilian make-up products by instrumental neutron activation analysis. Proceedings of the 2011 International Nuclear Atlantic Conference - INAC, 2011. Bele Horizonte, MG, Brazil, October 24-28, 2011.
11. Filon F.L., Boeniger M., Maina G., Adami G., Spinelli P., Damian A. Skin absorption of inorganic lead (PbO) and the effect of skin cleansers. J. Occup. Environ. Med. 2006, 48(7):692-699.
12. Filon F.L., D'Agostin F., Crosera M., Adami G., Bovenzi M., Maina G. In vitro absorption of metal powders through intact and damaged skin. Toxicol. In Vitro 2009, 23(4):574-579.
13. Gammelgaard B., Fullerton A., Avnstorp C., Menné T. Permeation of chromium salts through human skin in vitro. Contact Dermatitis 1992, 27(5):302-310.
14. Gondal M.A., Seddigi Z.S., Nasr M.M., Gondal B. Spectroscopic detection of health hazardous contaminants in lipstick using laser induced breakdown spectroscopy. J. Hazard. Mater. 2010, 175(1-3):726-732.
15. HC-SC, Health Canada-Santé Canada, 2012. Guidance on Heavy Metal Impurities in Cosmetics. Available at: < >. [Accessed 03 September 2013]. http://www.hc-sc.gc.ca/cps-spc/pubs/industheavy_metals-metaux_lourds/index-eng.php.
16. Hostynek J.J. Factors determining percutaneous metal absorption. Food Chem. Toxicol. 2003, 41(3):327-345.
17. Hostynek J.J., Dreher F., Nakada T., Schwindt D., Anigbogu A., Maibach H.I. Human stratum corneum adsorption of nickel salts. Investigation of depth profiles by tape stripping in vivo. Acta Derm. Venereol. 2001, S212:11-18.
18. Hostynek J.J., Maibach H.I. Copper hypersensitivity: dermatologic aspects. Dermatol. Ther. 2004, 17:238-333.
19. IARC, International Agency for Research on Cancer Chromium, nickel and welding 1990, vol. 49. IARC, Lyon, France.
20. IARC, International Agency for Research on Cancer Chlorinated Drinking-Water; Chlorination By-Products; Some Other Halogenated Compounds; Cobalt and Cobalt Compounds 1991, vol. 52. IARC, Lyon, France.
21. Iyer V.J., Banerjee G., Govindram C.B., Kamath V., Shinde S., Gaikwad A., Jerajani H.R., Raman G., Cherian K.M. Role of different valence states of chromium in the elicitation of allergic contact dermatitis. Contact Dermatitis 2002, 47:357-360.
22. Lacy S.A., Merritt K., Brown S.A., Puryear A. Distribution of nickel and cobalt following dermal and systemic administration with in vitro and in vivo studies. J. Biomed. Mater. Res. 1996, 32(2):279-283.
23. Larese Filon F., Maina G., Adami G., Venier M., Coceani N., Bussani R., Massiccio M., Barbieri P., Spinelli P. In vitro percutaneous absorption of cobalt. Int. Arch. Occup. Environ. Health 2004, 77(2):85-89.
24. Larese F., Adami G., Venier M., Maina G., Renzi N. In vitro percutaneous absorption of metal compounds. Toxicol. Lett. 2007, 170(1):49-56.
25. Larese Filon F., D'Agostin F., Crosera M., Adami G., Bovenzi M., Maina G. In vitro percutaneous absorption of chromium powder and the effect of skin cleanser. Toxicol. In Vitro 2008, 22(6):1562-1567.
26. Larese Filon F., D'Agostin F., Crosera M., Adami G., Bovenzi M., Maina G. In vitro absorption of metal powders through intact and damaged human skin. Toxicol. In Vitro 2009, 23:574-579.
27. 27Al NMR study of Al-ATP complexes. A possible relation with its biological applications. Nouveau/Chemie 1983, 7:579-585.
28. Linsey M., Milnes I. Heavy metal analysis of cosmetics and personal care products: a critical and unavoidable global challenge. Euro Cosmetics 2011, 10:17-19.
29. Machovcova A., Dastychiva E., Kostalova D., Vojtechovska A., Reslova J., Smejkalova D., Vaneckova J., Vocilkova A. Common contact sensitizers in the Czech Republic. Patch test results in 12,058 patients with suspected contact dermatitis. Contact Dermatitis 2005, 53(3):162-166.
30. Mennè T., Christopherson J., Green A. Epidemiology of Nickel Dermatitis. Nickel and the Skin: Immunology and Toxicology 1989, 109-115. CRC Press, Boca Raton. H.I. Maibach, T. Mennè (Eds.).
31. Miyajima H., Kono S., Takahashi Y., Sugimoto M. Increased lipid peroxidation and mitochondrial dysfunction in aceruloplasminemia brains. Blood Cells Mol. Dis. 2002, 29(3):433-438.
32. Nnorom I.C. Trace metals in cosmetic facial talcum powders marketed in Nigeria. Toxicol. Environ. Chem. 2011, 93(6):1135-1148.
33. Omolaoye J.A., Uzairu A., Gimba C.E. Heavy metal assessment of some eye shadow products imported into Nigeria from China. Arch. Appl. Sci. Res. 2010, 2(5):76-84.
34. Pardo J., Rodriguez-Serna M., De La Quadra J., Fortea J.M. Allergic contact stomatitis due to manganese in dental prosthesis. Contact Dermatitis 2004, 50:41.
35. Piccinini P., Piecha M., Torrent S.F. European survey on the content of lead in lip products. J. Pharm. Biomed. Anal. 2013, 76:225-233.
36. Salvador A., Pascual-Martí M.C., Aragó E., Chisvert A., March J.G. Determination of selenium, zinc and cadmium in antidandruff shampoos by atomic spectrometry after microwave assisted sample digestion. Talanta 2000, 51(6):1171-1177.
37. Scansetti G., Botta G.C., Spinelli P., Reviglione L., Ponzetti C. Absorption and excretion of cobalt in the hard metal industry. Sci. Total Environ. 1994, 150:141-144.
38. Senesse P., Meance S., Cottet V., Faivre J., Boutron-Ruault M.C. High dietary iron and copper and the risk of colorectal cancer: A case-control study in Burgundy. France Nutr. Cancer 2004, 49(1):66-71.
39. Sharma V.K., Chakrabarti A. Common contact sensitizers in Chandigarh, India. A study of 200 patients with the European standard series. Contact Dermatitis 1998, 38(3):127-131.
40. Tanojo H., Hostynek J.J., Mountford H.S., Maibach H.I. In vitro permeation of nickel salts through human stratum corneum. Acta Derm. Venereol. 2001, S212:19-23.
41. Thyssen J.P., Johansen J.D., Menné T. Contact allergy epidemics and their controls. Contact Dermatitis 2007, 56:185-195.
42. Ullah H., Noreen S., Fozia, Rehman A., Waseem A., Zubair S., Adnan M., Ahmad I. Comparative study of heavy metals content in cosmetic products of different countries marketed in Khyber Pakhtunkhwa, Paskistan. Arab. J. Chem. 2013, 1-3. 10.1016/j.arabjc.2013.09.021.
43. US FDA, 2007. Summary of color additives listed for use in the United States in foods, drugs, cosmetics, and medical devices. Color additives approved for use in cosmetics Part 73, subpart C: Color additives exempt from batch certification. Available from: . 2007. http://www.cfsan.fda.gov/dms/opa_col2.html.
44. Uter W., Aberer W., Armario-Hita J.C., Fernandez-Vozmediano J.M., Ayala F., Balato A., Bauer A., et al. Current patch test results with the European baseline series and extensions to it from the 'European Surveillance System on Contact Allergy' network, 2007-2008. Contact Dermatitis 2012, 67:9-19.
45. Van Lierde V., Chéry C.C., Roche N., Monstrey S., Moens L., Vanhaecke F. In vitro permeation of chromium species through porcine and human skin as determined by capillary electrophoresis-inductively coupled plasma-sector field mass spectrometry. Anal. Bioanal. Chem. 2006, 384(2):378-384.
46. Vilaplana J., Grimalt F., Romaguera C., Mascaro J.M. Cobalt content of household cleaning products. Contact Dermatitis 1987, 16:139-141.
47. WHO Guidelines for drinking water quality. Recommendations 2004, vol. 1. World Health Organization, Geneva, Switzerland.
48. Yabe S., Yamashita M., Momose S., Tahira K., Yoshida S., Li R., Yin S., Sato T. Synthesis and UV-shielding properties of metal oxide doped ceria via soft solution chemical processes. Int. J. Inorg. Mater. 2001, 3(7):1003-1008.