Influence of macromolecular precipitants on phase behavior of monoclonal antibodies

Biotechnology Progress

Volumn 31, Issue 1, 2015, Pages 145-153

  Rakel, Natalie ^a,b   Galm, Lara ^a   Bauer, Katharina Christin ^a   Hubbuch, Juergen ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^b ROCHE DIAGNOSTICS GMBH   (Germany)

Author keywords

Crystallization; Monoclonal antibody; Phase behavior; Protein interactions; Static light scattering

Indexed keywords

CRYSTALLIZATION; LIGHT SCATTERING; MACROMOLECULES; MOLECULAR WEIGHT; MONOCLONAL ANTIBODIES; OSMOSIS; PH; PHASE BEHAVIOR; PROTEINS; SURFACE PLASMON RESONANCE;

CROSS INTERACTIONS; DOWNSTREAM-PROCESSING; PROTEIN CRYSTALLIZATION; PROTEIN INTERACTION; SECOND VIRIAL COEFFICIENTS; STATIC LIGHT SCATTERING; THREEDIMENSIONAL (3-D); VIRIAL COEFFICIENT;

ANTIBODIES;

MACROGOL DERIVATIVE; MACROMOLECULE; MONOCLONAL ANTIBODY;

CHEMICAL MODEL; CHEMISTRY; CRYSTALLIZATION; LIGHT; MACROMOLECULE; PH; RADIATION SCATTERING;

ANTIBODIES, MONOCLONAL; CRYSTALLIZATION; HYDROGEN-ION CONCENTRATION; LIGHT; MACROMOLECULAR SUBSTANCES; MODELS, CHEMICAL; POLYETHYLENE GLYCOLS; SCATTERING, RADIATION;

EID: 84923526643     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.2027     Document Type: Article

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