Low serum tryptophan predicts higher mortality in cardiovascular disease

European Journal of Clinical Investigation

Volumn 45, Issue 3, 2015, Pages 247-254

  Murr, Christian ^a   Grammer, Tanja B ^b   Kleber, Marcus E ^b   Meinitzer, Andreas ^c   März, Winfried ^b,c,d   Fuchs, Dietmar ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c MEDICAL UNIVERSITY OF GRAZ   (Austria)

^d SYNLAB ACADEMY   (Germany)

Author keywords

C reactive protein; Coronary artery disease; Neopterin; Tryptophan

Indexed keywords

C REACTIVE PROTEIN; CREATININE; CYSTATIN C; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NEOPTERIN; TRIACYLGLYCEROL; TRYPTOPHAN; INDOLEAMINE 2,3 DIOXYGENASE; INDOLEAMINE 2,3-DIOXYGENASE 2, HUMAN;

ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; BODY MASS; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY RISK; CORRELATIONAL STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GLOMERULUS FILTRATION RATE; HUMAN; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; RISK ASSESSMENT; SMOKING; SYSTOLIC BLOOD PRESSURE; TRYPTOPHAN BLOOD LEVEL; ADOLESCENT; AGE; BLOOD; CARDIOVASCULAR DISEASE; CASE CONTROL STUDY; DEFICIENCY; IMMUNITY; IMMUNOLOGY; LIFE EXPECTANCY; METABOLISM; MORTALITY; PHYSIOLOGY; SURVIVAL ANALYSIS; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CASE-CONTROL STUDIES; FEMALE; HUMANS; IMMUNITY; INDOLEAMINE-PYRROLE 2,3,-DIOXYGENASE; LIFE EXPECTANCY; MALE; MIDDLE AGED; NEOPTERIN; SURVIVAL ANALYSIS; TRYPTOPHAN; YOUNG ADULT;

EID: 84923444765     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/eci.12402     Document Type: Article

References (36)

1. Chen Y, Guillemin GJ. Kynurenine pathway metabolites in humans: disease and healthy States. Int J Tryptophan Res 2009;2:1-19.
2. Werner ER, Bitterlich G, Fuchs D, Hausen A, Reibnegger G, Szabo G et al. Human macrophages degrade tryptophan upon induction by interferon-gamma. Life Sci 1987;41:273-80.
3. Weiss G, Murr C, Zoller H, Haun M, Widner B, Ludescher C et al. Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells. Clin Exp Immunol 1999;116:435-40.
4. Pfefferkorn ER. Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc Natl Acad Sci USA 1984;81:908-12.
5. de la Maza LM, Peterson EM. Dependence of the in vitro antiproliferative activity of recombinant human gamma-interferon on the concentration of tryptophan in culture media. Cancer Res 1988;48:346-50.
6. Ozaki Y, Edelstein MP, Duch DS. Induction of indoleamine 2, 3-dioxygenase: a mechanism of the antitumor activity of interferon gamma. Proc Natl Acad Sci USA 1988;85:1242-6.
7. Munn DH, Shafizadeh E, Attwood JT, Bondarev I, Pashine A, Mellor AL. Inhibition of T cell proliferation by macrophage tryptophan catabolism. J Exp Med 1999;189:1363-72.
8. Hwu PMX, Lapointe R, Do M, Taylor MW, Young HA. Indoleamine 2, 3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation. J Immunol 2000;164:3596-9.
9. Terness P, Bauer TM, Röse L, Dufter C, Watzlik A, Simon H et al. Inhibition of allogeneic T cell proliferation by indoleamine 2, 3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites. J Exp Med 2002;196:447-57.
10. Weiss G, Schroecksnadel K, Mattle V, Winkler C, Konwalinka G, Fuchs D. Possible role of cytokine-induced tryptophan degradation in anaemia of inflammation. Eur J Haematol 2004;72:130-4.
11. Widner B, Laich A, Sperner-Unterweger B, Ledochowski M, Fuchs D. Neopterin production tryptophan degradation and mental depression: what is the link? Brain Behav Immun 2002;16:590-5.
12. Dantzer R, O'Connor JC, Lawson MA, Kelley KW. Inflammation-associated depression: from serotonin to kynurenine. Psychoneuroendocrinology 2011;36:426-36.
13. Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature 2011;473:317-25.
14. Huber C, Batchelor JR, Fuchs D, Hausen A, Lang A, Niederwieser D et al. Immune response-associated production of neopterin - release from macrophages primarily under control of interferon-gamma. J Exp Med 1984;160:310-6.
15. Wirleitner B, Reider D, Ebner S, Böck G, Widner B, Jaeger M et al. Monocyte-derived dendritic cells release neopterin. J Leukoc Biol 2002;2:1148-53.
16. Fuchs D, Avanzas P, Arroyo-Espliguero R, Jenny M, Consuegra Sanchez L, Kaski JC. The role of neopterin in atherogenesis and cardiovascular risk stratification. Curr Med Chem 2009;16:4644-53.
17. Grammer TB, Fuchs D, Böhm BO, Winkelmann BR, Maerz W. Neopterin as a predictor of total and cardiovascular mortality in individuals undergoing angiography (The Ludwigshafen Risk and Cardiovascular Health Study). Clin Chem 2009;55:115-46.
18. Pedersen ER, Midttun Ø, Ueland PM, Schartum-Hansen H, Seifert R, Igland J et al. Systemic markers of interferon-γ-mediated immune activation and long-term prognosis in patients with stable coronary artery disease. Arterioscler Thromb Vasc Biol 2011;31:698-704.
19. Winkelmann BR, März W, Boehm BO, Zotz R, Hager J, Hellstern P et al. Rationale and design of the LURIC study: a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease. Pharmacogenomics 2001;2:S1-73.
20. Austen WG, Edwards JE, Frye RL, Gensini GG, Gott VL, Griffith LS et al. A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association. Circulation 1975;51(suppl 4):5-40.
21. Sourij H, Meinitzer A, Pilz S, Grammer TB, Winkelmann BR, Boehm BO et al. Arginine bioavailability ratios are associated with cardiovascular mortality in patients referred to coronary angiography. Atherosclerosis 2011;218:220-5.
22. Murr C, Widner B, Wirleitner B, Fuchs D. Neopterin as a marker for immune system activation. Curr Drug Metab 2002;3:175-7.
23. Stevens LA, Coresh J, Schmid CH, Feldman HI, Froissart M, Kusek J et al. Estimating GFR using serum cystatin C alone and in combination with serum creatinine: a pooled analysis of 3, 418 individuals with CKD. Am J Kidney Dis 2008;51:395-406.
24. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958;53:457-81.
25. Cox DR. Regression models and life tables (with discussion). J R Stat Soc 1972;34:187-220.
26. Pilz S, Dobnig H, Winklhofer-Roob BM, Renner W, Seelhorst U, Wellnitz B et al. Low serum zinc concentrations predict mortality in patients referred to coronary angiography. Br J Nutr 2009;101:1534-40.
27. Weinlich G, Murr C, Richardsen L, Winkler C, Fuchs D. Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients. Dermatology 2007;214:8-14.
28. Schroecksnadel K, Zangerle R, Bellmann-Weiler R, Garimorth K, Weiss G, Fuchs D. Indoleamine-2, 3-dioxygenase and other interferon-gamma-mediated pathways in patients with human immunodeficiency virus infection. Curr Drug Metab 2007;8:225-36.
29. Wirleitner B, Rudzite V, Neurauter G, Murr C, Kalnins U, Erglis A et al. Immune activation and degradation of tryptophan in coronary heart disease. Eur J Clin Invest 2003;33:550-4.
30. Niinisalo P, Raitala A, Pertovaara M, Oja SS, Lehtimäki T, Kähönen M et al. Indoleamine 2, 3-dioxygenase activity associates with cardiovascular risk factors: the Health 2000 study. Scand J Clin Lab Invest 2008;68:767-70.
31. Sulo G, Vollset SE, Nygård O, Midttun Ø, Ueland PM, Eussen SJ et al. Neopterin and kynurenine-tryptophan ratio as predictors of coronary events in older adults, the Hordaland Health Study. Int J Cardiol 2013;168:1435-40.
32. Schroecksnadel K, Wirleitner B, Winkler C, Fuchs D. Monitoring tryptophan metabolism in chronic immune activation. Clin Chim Acta 2006;364:82-90.
33. Widner B, Werner ER, Schennach H, Wachter H, Fuchs D. Simultaneous measurement of serum tryptophan and kynurenine by HPLC. Clin Chem 1997;43:2424-6.
34. Mellor AL, Munn DH. Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation? Immunol Today 1999;20:469-73.
35. Shankman SA, Nadelson J, McGowan SK, Sovari AA, Vidovich MI. The predictive power of depression screening procedures for veterans with coronary artery disease. Vasc Health Risk Manag 2012;8:233-8.
36. van Straten AH, Hamad MA, van Zundert AJ, Martens EJ, Schönberger JP, de Wolf AM. Preoperative hemoglobin level as a predictor of survival after coronary artery bypass grafting: a comparison with the matched general population. Circulation 2009;120:118-25.