Vitamin D insufficiency is associated with reduced parasympathetic nerve fiber function in type 2 diabetes

Endocrine Practice

Volumn 21, Issue 2, 2015, Pages 174-181

  Maser, Raelene E ^a,b   Lenhard, M James ^b   Pohlig, Ryan T ^a  

^a UNIVERSITY OF DELAWARE   (United States)

^b CHRISTIANA CARE HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; ADIPONECTIN; INSULIN; 25-HYDROXYVITAMIN D; VITAMIN D;

ADULT; AGED; ARTICLE; AUTONOMIC DYSFUNCTION; BODY MASS; CALCIUM METABOLISM; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GLYCEMIC CONTROL; HEART INNERVATION; HUMAN; HYPERPNEA; INSULIN RESISTANCE; MALE; METABOLIC PARAMETERS; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; PARASYMPATHETIC FUNCTION; PARASYMPATHETIC NERVE; RR INTERVAL; VITAMIN D DEFICIENCY; ANALOGS AND DERIVATIVES; BLOOD; CHOLINERGIC SYSTEM; COMPLICATION; NERVE FIBER; PATHOPHYSIOLOGY; PHYSIOLOGY;

AGED; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE FIBERS; PARASYMPATHETIC NERVOUS SYSTEM; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84923419205     PISSN: 1530891X     EISSN: 19342403     Source Type: Journal    
DOI: 10.4158/EP14332.OR     Document Type: Article

References (28)

1. Shehab D, Al-Jarallah K, Mojiminiyi OA, Al Mohamedy H, Abdella NA. Does vitamin D deficiency play a role in peripheral neuropathy in type 2 diabetes. Diabet Med. 2012; 29: 43-49.
2. Soderstrom LH, Johnson SP, Diaz VA, Mainous AG III. Association between vitamin D and diabetic neuropathy in a nationally representative sample: results from 2001-2004 NHANES. Diabet Med. 2012; 29: 50-55.
3. Skalli S, Muller M, Pradines S, Halimi S, Wion-Barbot N. Vitamin D deficiency and peripheral diabetic neuropathy. Eur J Intern Med. 2012; 23: e67-e68.
4. Sytze Van Dam P, Cotter MA, Bravenboer B, Cameron NE. Pathogenesis of diabetic neuropathy: focus on neurovascular mechanisms. Eur J Pharmacol. 2013; 719: 180-186.
5. Vinik AI, Strotmeyer ES, Nakave AA, Patel CV. Diabetic neuropathy in older adults. Clin Geriatr Med. 2008; 24: 407-435.
6. Riaz S, Malcangio M, Miller M, Tomlinson DR. A vitamin D(3) derivative (CB1093) induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats. Diabetologia. 1999; 42: 1308-1313.
7. Buell JS, Dawson-Hughes B. Vitamin D and neurocognitive dysfunction: preventing "D"ecline. Mol Aspects Med. 2008; 29: 415-422.
8. Mann MC, Exner DV, Hemmelgarn BR, et al. Vitamin D levels are associated with cardiac autonomic activity in healthy humans. Nutrients. 2013; 5: 2114-2127.
9. Vinik AI, Erbas T, Casellini CM. Diabetic cardiac autonomic neuropathy, inflammation and cardiovascular disease. J Diabetes Investig. 2013; 4: 4-18.
10. Maser RE, Lenhard MJ. Cardiovascular autonomic neuropathy due to diabetes mellitus: clinical manifestations, consequences, and treatment. J Clin Endocrinol Metab. 2005; 90: 5896-5903.
11. Maser RE, Mitchell BD, Vinik AI, Freeman R. The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-Analysis. Diabetes Care. 2003; 26: 1895-1901.
12. Maser RE, Lenhard MJ. Effect of treatment with losartan on cardiovascular autonomic and large sensory nerve fiber function in individuals with diabetes mellitus: a 1-year randomized, controlled trial. J Diabetes Complications. 2003; 17: 286-291.
13. Schumer M, Burton G, Burton C, Crum D, Pfeifer MA. Diabetic autonomic neuropathy-part I. Autonomic nervous system data analysis by a computerized central unit in a multicenter trial. Am J Med. 1988; 85: 137-143.
14. Pfeifer MA, Cook D, Brodsky J, et al. Quantitative evaluation of cardiac parasympathetic activity in normal and diabetic man. Diabetes. 1982; 31: 339-345.
15. Schumer MP, Joyner SA, Pfeifer MA. Cardiovascular autonomic neuropathy testing in patients with diabetes. Diabetes Spectr. 1998; 11: 227-231.
16. Gelber DA, Pfeifer M, Dawson B, Schumer M. Cardiovascular autonomic nervous system tests: determination of normative values and effect of confounding variables. J Auton Nerv Syst. 1997; 62: 40-44.
17. Pfeifer MA, Schumer MP. Cardiovascular autonomic neuropathy. Where have we been and where are we going. Diabetes Care. 1994; 17: 1545-1546.
18. Levy JC, Matthews DR, Hermans MP. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care. 1998; 21: 2191-2192.
19. Makariou S, Liberopoulos EN, Elisaf M, Challa A. Novel roles of vitamin D in disease: what is new in 2011. Eur J Intern Med. 2011; 22: 355-362.
20. Palomer X, González-Clemente JM, Blanco-Vaca F, Mauricio D. Role of vitamin D in the pathogenesis of type 2 diabetes mellitus. Diabetes Obes Metab. 2008; 10: 185-197.
21. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004; 79: 820-825.
22. Bell DS. Reversal of the symptoms of diabetic neuropathy through correction of vitamin D deficiency in a type 1 diabetic patient. Case Rep Endocrinol. 2012; 2012: 165056.
23. Lee P, Chen R. Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain. Arch Intern Med. 2008; 168: 771-772.
24. Spallone V, Ziegler D, Freeman R, et al. Cardiovascular autonomic neuropathy in diabetes: clinical impact, assessment, diagnosis, and management. Diabetes Metab Res Rev. 2011; 27: 639-653.
25. Vinik AI. The conductor of the autonomic orchestra. Front Endocrinol (Lausanne). 2012; 3: 71.
26. Zhou J, Zhou S. Inflammation: therapeutic targets for diabetic neuropathy. Mol Neurobiol. 2014; 49: 536-546.
27. McCarty MF. Secondary hyperparathyroidism promotes the acute phase response-A rationale for supplemental vitamin D in prevention of vascular events in the elderly. Med Hypotheses. 2005; 64: 1022-1026.
28. N ikooyeh B, Neyestani TR, Tayebinejad N, et al. Daily intake of vitamin D-or calcium-vitamin D-fortified Persian yogurt drink (doogh) attenuates diabetes-induced oxidative stress: evidence for antioxidative properties of vitamin D. J Hum Nutr Diet. 2014; 27 Suppl 2: 276-283.