Visually induced nausea causes characteristic changes in cerebral, autonomic and endocrine function in humans

Journal of Physiology

Volumn 593, Issue 5, 2015, Pages 1183-1196

  Farmer, Adam D ^a,b   Ban, Vin F ^a   Coen, Steven J ^a,c   Sanger, Gareth J ^a   Barker, Gareth J ^c   Gresty, Michael A ^d   Giampietro, Vincent P ^c   Williams, Steven C ^c   Webb, Dominic L ^e   Hellström, Per M ^e   Andrews, Paul L R ^f   Aziz, Qasim ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY HOSPITALS OF NORTH MIDLANDS NHS TRUST   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

^e UPPSALA UNIVERSITY   (Sweden)

^f ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GHRELIN; VASOPRESSIN; VASOPRESSIN DERIVATIVE;

ADULT; ANTERIOR CINGULATE; ANXIETY; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; BRAIN FUNCTION; CONTROLLED STUDY; ELECTROGASTROGRAPHY; ENDOCRINE FUNCTION; FEMALE; FUNCTIONAL NEUROIMAGING; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; INFERIOR FRONTAL GYRUS; MALE; NAUSEA; NORMAL HUMAN; OCCIPITAL GYRUS; PRIORITY JOURNAL; PSYCHOPHYSIOLOGY; STIMULUS RESPONSE; SYMPATHETIC FUNCTION; VAGUS TONE; VASOPRESSIN BLOOD LEVEL; VISUAL ANALOG SCALE; VISUAL STIMULATION; AUTONOMIC NERVOUS SYSTEM; BLOOD; BRAIN CORTEX; CASE CONTROL STUDY; ENDOCRINE SYSTEM; MIDDLE AGED; MOTION SICKNESS; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADULT; AUTONOMIC NERVOUS SYSTEM; CASE-CONTROL STUDIES; CEREBRAL CORTEX; ENDOCRINE SYSTEM; FEMALE; GHRELIN; HUMANS; MALE; MIDDLE AGED; MOTION SICKNESS; NAUSEA; VASOPRESSINS;

EID: 84923387202     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2014.284240     Document Type: Article

References (63)

1. Andrews PL & Sanger GJ (2014). Nausea and the quest for the perfect anti-emetic. Eur J Pharmacol 722, 108-121.
2. Beissner F, Meissner K, Bar KJ & Napadow V (2013). The autonomic brain: an activation likelihood estimation meta-analysis for central processing of autonomic function. J Neurosci 33, 10503-10511.
3. Benarroch EE, Opfer-Gehrking TL & Low PA (1991). Use of the photoplethysmographic technique to analyze the Valsalva maneuver in normal man. Muscle Nerve 14, 1165-1172.
4. Benson PW, Hooker JB, Koch KL & Weinberg RB (2012). Bitter taster status predicts susceptibility to vection-induced motion sickness and nausea. Neurogastroenterol Motil 24, 134-140, e186.
5. Bos JE & Bles W (2004). Motion sickness induced by optokinetic drums. Aviat Space Environ Med 75, 172-174.
6. Bubka A & Bonato F (2003). Optokinetic drum tilt hastens the onset of vection-induced motion sickness. Aviat Space Environ Med 74, 315-319.
7. Bullmore ET, Suckling J, Overmeyer S, Rabe-Hesketh S, Taylor E & Brammer MJ (1999). Global, voxel, and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain. IEEE Trans Med Imaging 18, 32-42.
8. Chelen WE, Kabrisky M & Rogers SK (1993). Spectral analysis of the electroencephalographic response to motion sickness. Aviat Space Environ Med 64, 24-29.
9. Coen SJ, Yaguez L, Aziz Q, Mitterschiffthaler MT, Brammer M, Williams SC & Gregory LJ (2009). Negative mood affects brain processing of visceral sensation. Gastroenterology 137, 253-261.
10. Critchley HD & Harrison NA (2013). Visceral influences on brain and behavior. Neuron 77, 624-638.
11. Della-Justina HM, Gamba HR, Lukasova K, Nucci-da-Silva MP, Winkler AM & Amaro E, Jr (2015). Interaction of brain areas of visual and vestibular simultaneous activity with fMRI. Exp Brain Res 233, 237-252.
12. Eckert S & Horstkotte D (2002). Comparison of Portapres non-invasive blood pressure measurement in the finger with intra-aortic pressure measurement during incremental bicycle exercise. Blood Press Monit 7, 179-183.
13. European Society of Cardiology (1996). Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation 93, 1043-1065.
14. Ejskjaer N, Wo JM, Esfandyari T, Mazen Jamal M, Dimcevski G, Tarnow L, Malik RA, Hellstrom PM, Mondou E, Quinn J, Rousseau F & McCallum RW (2013). A phase 2a, randomized, double-blind 28-day study of TZP-102 a ghrelin receptor agonist for diabetic gastroparesis. Neurogastroenterol Motil 25, e140-150.
15. Farmer AD, Al Omran Y, Aziz Q & Andrews PL (2014a). The role of the parasympathetic nervous system in visually induced motion sickness: systematic review and meta-analysis. Exp Brain Res 232, 2665-2673.
16. Farmer AD, Coen SJ, Kano M, Paine PA, Shwahdi M, Jafari J, Kishor J, Worthen SF, Rossiter HE, Kumari V, Williams SC, Brammer M, Giampietro VP, Droney J, Riley J, Furlong PL, Knowles CH, Lightman SL & Aziz Q (2013a). Psychophysiological responses to pain identify reproducible human clusters. Pain 154, 2266-2276.
17. Farmer AD, Coen SJ, Kano M, Weltens N, Ly HG, Botha C, Paine PA, Oudenhove LV & Aziz Q (2014b). Normal values and reproducibility of the real-time index of vagal tone in healthy humans: a multi-center study. Ann Gastroenterol 27, 362-368.
18. Farmer AD, Coen SJ, Kano M, Worthen SF, Rossiter HE, Navqi H, Scott SM, Furlong PL & Aziz Q (2013b). Psychological traits influence autonomic nervous system recovery following esophageal intubation in health and functional chest pain. Neurogastroenterol Motil 25, 950-e772.
19. Gianaros PJ, Muth ER, Mordkoff JT, Levine ME & Stern RM (2001a). A questionnaire for the assessment of the multiple dimensions of motion sickness. Aviat Space Environ Med 72, 115-119.
20. Gianaros PJ, Quigley KS, Muth ER, Levine ME, Vasko RC Jr & Stern RM (2003). Relationship between temporal changes in cardiac parasympathetic activity and motion sickness severity. Psychophysiology 40, 39-44.
21. Gianaros PJ, Stern RM, Morrow GR & Hickok JT (2001b). Relationship of gastric myoelectrical and cardiac parasympathetic activity to chemotherapy-induced nausea. J Psychosom Res 50, 263-266.
22. Golding JF (1998). Motion sickness susceptibility questionnaire revised and its relationship to other forms of sickness. Brain Res Bull 47, 507-516.
23. Golding JF, Doolan K, Acharya A, Tribak M & Gresty MA (2012). Cognitive cues and visually induced motion sickness. Aviat Space Environ Med 83, 477-482.
24. Hettinger LJ, Schmidt T, Jones DL & Keshavarz, B ( 2014). Illusory self-motion in virtual environments. In Handbook of Virtual Environments: Design, Implementation, and Applications, ed. Hale KS & Stanney KM, 2nd edn, pp. 435-466. CRC Press, San Diego.
25. Himi N, Koga T, Nakamura E, Kobashi M, Yamane M & Tsujioka K (2004). Differences in autonomic responses between subjects with and without nausea while watching an irregularly oscillating video. Auton Neurosci 116, 46-53.
26. Holmes AM, Rudd JA, Tattersall FD, Aziz Q & Andrews PL (2009). Opportunities for the replacement of animals in the study of nausea and vomiting. Br J Pharmacol 157, 865-880.
27. Hursti TJ, Fredrikson M, Steineck G, Borjeson S, Furst CJ & Peterson C (1993). Endogenous cortisol exerts antiemetic effect similar to that of exogenous corticosteroids. Br J Cancer 68, 112-114.
28. Julu PO ( 1992). A linear scale for measuring vagal tone in man. J Auton Pharmacol 12, 109-115.
29. Kennedy RS, Drexler J & Kennedy RC (2010). Research in visually induced motion sickness. Appl Ergon 41, 494-503.
30. Keshavarz B & Hecht H (2011). Validating an efficient method to quantify motion sickness. Hum Factors 53, 415-426.
31. Kim MS, Chey WD, Owyang C & Hasler WL (1997). Role of plasma vasopressin as a mediator of nausea and gastric slow wave dysrhythmias in motion sickness. Am J Physiol 272, G853-862.
32. Klose J, Otto C, Enck P, Klosterhalfen S, Heldwein W & Otto B (2006). Does ghrelin increase during nausea? Z Gastroenterol 44, P_22.
33. Klosterhalfen S, Pan F, Kellermann S & Enck P (2006). Gender and race as determinants of nausea induced by circular vection. Gend Med 3, 236-242.
34. Koch KL (1999). Illusory self-motion and motion sickness: a model for brain-gut interactions and nausea. Dig Dis Sci 44, 53S-57S.
35. Koch KL, Stern RM, Vasey MW, Seaton JF, Demers LM & Harrison TS (1990). Neuroendocrine and gastric myoelectrical responses to illusory self-motion in humans. Am J Physiol 258, E304-310.
36. Liu YL, Malik NM, Sanger GJ & Andrews PL (2006). Ghrelin alleviates cancer chemotherapy-associated dyspepsia in rodents. Cancer Chemother Pharmacol 58, 326-333.
37. McCrae RR & Costa PT, Jr (1987). Validation of the five-factor model of personality across instruments and observers. J Pers Soc Psychol 52, 81-90.
38. Miller EF 2nd & Graybiel A (1970). A provocative test for grading susceptibility to motion sickness yielding a single numerical score. Acta Otolaryngol Suppl 274, 1-20.
39. Miller AD, Rowley HA, Roberts TP & Kucharczyk J (1996). Human cortical activity during vestibular- and drug-induced nausea detected using MSI. Ann N Y Acad Sci 781, 670-672.
40. Morrow GR, Hickok JT, Andrews PL & Stern RM (2002). Reduction in serum cortisol after platinum based chemotherapy for cancer: a role for the HPA axis in treatment-related nausea? Psychophysiology 39, 491-495.
41. Muth ER (2006). Motion and space sickness: intestinal and autonomic correlates. Auton Neurosci 129, 58-66.
42. Napadow V, Sheehan J, Kim J, Dassatti A, Thurler AH, Surjanhata B, Vangel M, Makris N, Schaechter JD & Kuo B (2013a). Brain white matter microstructure is associated with susceptibility to motion-induced nausea. Neurogastroenterol Motil 25, 448-450, e303.
43. Napadow V, Sheehan JD, Kim J, Lacount LT, Park K, Kaptchuk TJ, Rosen BR & Kuo B (2013b). The brain circuitry underlying the temporal evolution of nausea in humans. Cereb Cortex 23, 806-813.
44. Netter-Munkelt P, Mau G & Konig B (1972). The dimension of neuroticism as a modifying factor in the association between biological conditions and nausea in pregnancy. J Psychosom Res 16, 395-404.
45. Ohyama S, Nishiike S, Watanabe H, Matsuoka K, Akizuki H, Takeda N & Harada T (2007). Autonomic responses during motion sickness induced by virtual reality. Auris Nasus Larynx 34, 303-306.
46. Oldfield RC ( 1971). The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9, 97-113.
47. Paine P, Worthen SF, Gregory LJ, Thompson DG & Aziz Q (2009). Personality differences affect brainstem autonomic responses to visceral pain. Neurogastroenterol Motil 21, 1155-1198.
48. Parkman HP, Harris AD, Miller MA & Fisher RS (1996). Influence of age, gender, and menstrual cycle on the normal electrogastrogram. Am J Gastroenterol 91, 127-133.
49. Percie du Sert N & Andrews PL (2014). The ferret in nausea and vomiting research: lessons in translation of basic science to the clinic. In Biology and Diseases of the Ferret, ed. Marini RP & Fox JG, pp. 735-778. John Wiley and Sons, New York.
50. Percie du Sert N, Chu KM, Wai MK, Rudd JA & Andrews PL (2010). Telemetry in a motion-sickness model implicates the abdominal vagus in motion-induced gastric dysrhythmia. Exp Physiol 95, 768-773.
51. Rudd JA, Ngan MP, Wai MK, King AG, Witherington J, Andrews PL & Sanger GJ (2006). Anti-emetic activity of ghrelin in ferrets exposed to the cytotoxic anti-cancer agent cisplatin. Neurosci Lett 392, 79-83.
52. Seth AK, Suzuki K & Critchley HD (2011). An interoceptive predictive coding model of conscious presence. Front Psychol 2, 395.
53. Shupak A & Gordon CR (2006). Motion sickness: advances in pathogenesis, prediction, prevention, and treatment. Aviat Space Environ Med 77, 1213-1223.
54. Spielberger CD (1983). Manual for the State/Trait Anxiety Inventory (Form Y): (Self Evaluation Questionnaire). Consulting Psychologists Press, Palo Alto.
55. Stern RM, Koch KL & Andrews PLR (2011). Nausea: Mechanisms and Management. Oxford University Press, New York.
56. Stern RM, Koch KL, Stewart WR & Lindblad IM (1987). Spectral analysis of tachygastria recorded during motion sickness. Gastroenterology 92, 92-97.
57. Toichi M, Sugiura T, Murai T & Sengoku A (1997). A new method of assessing cardiac autonomic function and its comparison with spectral analysis and coefficient of variation of R-R interval. J Auton Nerv Syst 62, 79-84.
58. Willert RP, Woolf CJ, Hobson AR, Delaney C, Thompson DG & Aziz Q (2004). The development and maintenance of human visceral pain hypersensitivity is dependent on the N-methyl-d-aspartate receptor. Gastroenterology 126, 683-692.
59. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA & Bloom SR (2001). Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86, 5992.
60. Xu LH, Koch KL, Summy-Long J, Stern RM, Seaton JF, Harrison TS, Demers LM & Bingaman S (1993). Hypothalamic and gastric myoelectrical responses during vection-induced nausea in healthy Chinese subjects. Am J Physiol 265, E578-584.
61. Yen M & Lo LH (2002). Examining test-retest reliability: an intra-class correlation approach. Nurs Res 51, 59-62.
62. Yen Pik Sang FD, Golding JF & Gresty MA (2003). Suppression of sickness by controlled breathing during mildly nauseogenic motion. Aviat Space Environ Med 74, 998-1002.
63. Zigmond AS & Snaith RP (1983). The hospital anxiety and depression scale. Acta Psychiatr Scand 67, 361-370.