Upregulation of gingival tissue miR-200b in obese periodontitis subjects

Journal of Dental Research

Volumn 94, Issue , 2015, Pages 59S-69S

  Kalea, A Z ^a   Hoteit, R ^a   Suvan, J ^a   Lovering, R C ^a   Palmen, J ^a   Cooper, J A ^a   Khodiyar, V K ^a   Harrington, Z ^b   Humphries, S E ^a   D'Aiuto, F ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF PLYMOUTH   (United Kingdom)

Author keywords

angiogenesis; epithelial; microRNA 200b; obesity; periodontal disease; wound healing

Indexed keywords

DNA BINDING PROTEIN; GATA2 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; MICRORNA; MIRN200 MICRORNA, HUMAN; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 2; VASCULOTROPIN RECEPTOR 2; ZEB1 PROTEIN, HUMAN; ZEB2 PROTEIN, HUMAN; ZINC FINGER PROTEIN;

ADULT; ANGIOGENESIS; BODY WEIGHT; CELL DIFFERENTIATION; CELL MOTION; COMPARATIVE STUDY; FEMALE; GENE EXPRESSION PROFILING; GENETICS; GINGIVA; HUMAN; MALE; METABOLISM; OBESITY; PERIODONTITIS; PROCEDURES; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ADULT; BODY WEIGHT; CELL DIFFERENTIATION; CELL MOVEMENT; DNA-BINDING PROTEINS; FEMALE; GATA2 TRANSCRIPTION FACTOR; GENE EXPRESSION PROFILING; GINGIVA; HOMEODOMAIN PROTEINS; HUMANS; MALE; MICRORNAS; NEOVASCULARIZATION, PHYSIOLOGIC; OBESITY; PERIODONTITIS; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTORS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; ZINC FINGERS;

EID: 84923377578     PISSN: 00220345     EISSN: 15440591     Source Type: Journal    
DOI: 10.1177/0022034514568197     Document Type: Article

References (40)

1. Ahn SM, Cha JY, Kim J, Kim D, Trang HT, Kim YM, Cho YH, Park D, Hong S. Smad3 regulates E-cadherin via miRNA-200 pathway. Oncogene. 2012 ; 31: 3051-3059
2. Alisi A, Da Sacco L, Bruscalupi G, Piemonte F, Panera N, De Vito R, Leoni S, Bottazzo GF, Masotti A, Nobili V. Mirnome analysis reveals novel molecular determinants in the pathogenesis of diet-induced nonalcoholic fatty liver disease. Lab Invest. 2011 ; 91: 283-293
3. Artese L, Piattelli A, de Gouveia Cardoso LA, Ferrari DS, Onuma T, Piccirilli M, Faveri M, Perrotti V, Simion M, Shibli JA. Immunoexpression of angiogenesis, nitric oxide synthase, and proliferation markers in gingival samples of patients with aggressive and chronic periodontitis. J Periodontol. 2010 ; 81: 718-726
4. Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 2000 ; 25: 25-29
5. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009 ; 136: 215-233
6. Boesing F, Patiño JS, da Silva VR, Moreira EA. The interface between obesity and periodontitis with emphasis on oxidative stress and inflammatory response. Obes Rev. 2009 ; 10: 290-297
7. Brabletz S, Brabletz T. The ZEB/miR-200 feedback loop: a motor of cellular plasticity in development and cancer?. EMBO Rep. 2010 ; 11: 670-677
8. Chan YC, Roy S, Khanna S, Sen CK. Downregulation of endothelial microRNA-200b supports cutaneous wound angiogenesis by desilencing GATA binding protein 2 and vascular endothelial growth factor receptor 2. Arterioscler Thromb Vasc Biol. 2012 ; 32: 1372-1382
9. Cong N, Du P, Zhang A, Shen F, Su J, Pu P, Wang T, Zjang J, Kang C, Zhang Q. Downregulated microRNA-200a promotes EMT and tumor growth through the wnt/β-catenin pathway by targeting the E-cadherin repressors ZEB1/ZEB2 in gastric adenocarcinoma. Oncol Rep. 2013 ; 29: 1579-1587
10. Dalman MR, Deeter A, Nimishakavi G, Duan ZH. Fold change and p-value cuts significantly alter microarray interpretations. BMC Bioinformatics. 13 Suppl. 2012 ; 2: S11
11. Draghici S, Khatri P, Eklund AC, Szallasi Z. Reliability and reproducibility issues in DNA microarray measurements. Trends Genet. 2006 ; 22: 101-109
12. Dweep H, Sticht C, Pandey P, Gretz N. miRWalk-database: prediction of possible miRNA binding sites by "walking" the genes of three genomes. J Biomed Inform. 2011 ; 44: 839-847
13. Fichtlscherer S, De Rosa S, Fox H, Schwietz T, Fischer A, Liebetrau C, Weber M, Hamm CW, Röxe T, Müller-Ardogan M, et al. Circulating microRNAs in patients with coronary artery disease. Circ Res. 2010 ; 107: 677-684
14. Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, Vadas MA, Khew-Goodall Y, Goodall GJ. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol. 2008 ; 10: 593-601
15. Howe EN, Cochrane DR, Richer JK. Targets of miR-200c mediate suppression of cell motility and anoikis resistance. Breast Cancer Res. 2011 ; 13 (2). R45
16. Hsu SD, Lin FM, Wu WY, Liang C, Huang WC, Chan WL, Tsai WT, Chen GZ, Lee CJ, Chiu CM, et al. miRTarBase: a database curates experimentally validated microRNA-target interactions. Nucleic Acids Res. 2011 ; 39 (database issue). D163 - D169
17. Hu Y, Zhang R, Zhang Y, Li J, Grossmann R, Zhao R. In ovo leptin administration affects hepatic lipid metabolism and microRNA expression in newly hatched broiler chickens. J Anim Sci Biotechnol. 2012 ; 3: 16
18. Kornman KS, Van Dyke TE. Bringing light to the heat: "inflammation and periodontal diseases: a reappraisal. J Periodontol. 2008 ; 79: 1313
19. Korpal M, Lee ES, Hu G, Kang Y. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem. 2008 ; 283: 14910-14914
20. Lim WH, Liu B, Cheng D, Williams BO, Mah SJ, Helms JA. Wnt signaling regulates homeostasis of the periodontal ligament. J Periodontal Res. 2014a ; 49: 751-759
21. Lim WH, Liu B, Hunter DJ, Cheng D, Mah SJ, Helms JA. Downregulation of Wnt causes root resorption. Am J Orthod Dentofacial Orthop. 2014b ; 146: 337-345
22. Miyazaki S, Yamamoto H, Miyoshi N, Takahashi H, Suzuki Y, Haraguchi N, Ishii H, Doki Y, Mori M. Emerging methods for preparing iPS cells. Jpn J Clin Oncol. 2012 ; 42: 773-779
23. Nahid MA, Rivera M, Lucas A, Chan EK, Kesavalu L. Polymicrobial infection with periodontal pathogens specifically enhances microRNA miR-146a in ApoE-/- mice during experimental periodontal disease. Infect Immun. 2011 ; 79: 1597-1605
24. Nokhbehsaim M, Keser S, Nogueira AV, Jäger A, Jepsen S, Cirelli JA, Bourauel C, Eick S, Deschner J. Leptin effects on the regenerative capacity of human periodontal cells. Int J Endocrinol. 2014 ; 2014: 180304
25. Oger F, Gheeraert C, Mogilenko D, Benomar Y, Molendi-Coste O, Bouchaert E, Caron S, Dombrowicz D, Pattou F, Duez H, et al. Cell-specific dysregulation of microRNA expression in obese white adipose tissue. J Clin. Endocrinol Metab. 2014 ; 99: 2821-2833
26. Paraskevi A, Theodoropoulos G, Papaconstantinou I, Mantzaris G, Nikiteas N, Gazouli M. Circulating microRNA in inflammatory bowel disease. J Crohns Colitis. 2012 ; 6: 900-904
27. Perri R, Nares S, Zhang S, Barros SP, Offenbacher S. MicroRNA modulation in obesity and periodontitis. J Dent Res. 2012 ; 91: 33-38
28. Pio G, Malerba D, D'Elia D, Ceci M. Integrating microRNA target predictions for the discovery of gene regulatory networks: a semi-supervised ensemble learning approach. BMC Bioinformatics. 2014 ; 15: S4
29. Pritchard CC, Cheng HH, Tewari M. MicroRNA profiling: approaches and considerations. Nat Rev Genet. 2012 ; 13: 358-369
30. Reimand J, Arak T, Vilo J. g:Profiler: a web server for functional interpretation of gene lists (2011 update). Nucleic Acids Res. 2011 ; 39 (web server issue). W307 - W315
31. Russo F, Di Bella S, Nigita G, Macca V, Laganà A, Giugno R, Pulvirenti A, Ferro A. miRandola: extracellular circulating microRNAs database. PloS One. 2012 ; 7 (10). e47786
32. Shin JO, Kim EJ, Cho KW, Nakagawa E, Kwon HJ, Cho SW, Jung HS. BMP4 signaling mediates Zeb family in developing mouse tooth. Histochem Cell Biol. 2012 ; 137: 791-800
33. Stoecklin-Wasmer C, Guarnieri P, Celenti R, Demmer RT, Kebschull M, Papapanou PN. MicroRNAs and their target genes in gingival tissues. J Dent Res. 2012 ; 91: 934-940
34. Suvan J, D'Aiuto F, Moles DR, Petrie A, Donos N. Association between overweight/obesity and periodontitis in adults: a systematic review. Obes Rev. 2011 ; 12: e381 - e404
35. Suvan J, Petrie A, Moles DR, Nibali L, Patel K, Darbar U, Donos N, Tonetti M, D'Aiuto F. Body mass index as a predictive factor of periodontal therapy outcomes. J Dent Res. 2014 ; 93: 49-54
36. Tomikawa K, Yamamoto T, Shiomi N, Shimoe M, Hongo S, Yamashiro K, Yamaguchi T, Maeda H, Takashiba S. Smad2 decelerates re-epithelialization during gingival wound healing. J Dent Res. 2012 ; 91: 764-770
37. Tryndyak VP, Latendresse JR, Montgomery B, Ross SA, Beland FA, Rusyn I, Pogribny IP. Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet. Toxicol Appl Pharmacol. 2012 ; 262: 52-59
38. Wendlandt EB, Graff JW, Gioannini TL, McCaffrey AP, Wilson ME. The role of microRNAs miR-200b and miR-200c in TLR4 signaling and NF-κB activation. Innate Immun. 2012 ; 18: 846-855
39. World Health Organization. 2012. The international classification of adult underweight, overweight and obesity according to BMI. [accessed 2014 Dec 22]. http://apps.who.int/bmi/index.jsp?introPage=intro-3.html.
40. Xie Y, Shu R, Jiang S, Liu D, Zhang X. Comparison of microRNA profiles of human periodontal diseased and healthy gingival tissues. Int J Oral Sci. 2011 ; 3: 125-134