Discovery of native autoantigens via antigen surrogate technology: Application to type 1 diabetes

ACS Chemical Biology

Volumn 10, Issue 2, 2015, Pages 401-412

  Doran, Todd M ^a   Simanski, Scott ^a   Kodadek, Thomas ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 65 ANTIBODY; PEPTOID; AUTOANTIBODY; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 2; IMMUNOGLOBULIN G; MOLECULAR LIBRARY; NITRIC OXIDE DIOXYGENASE; OXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PURIFICATION; ARTICLE; CELL LYSATE; COMBINATORIAL LIBRARY; CONTROLLED STUDY; HUMAN; IMMUNOAFFINITY CHROMATOGRAPHY; INSULIN DEPENDENT DIABETES MELLITUS; INTERMETHOD COMPARISON; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PRIORITY JOURNAL; PROTEIN BINDING; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; GENETICS; IMMUNOLOGY; METABOLISM; MOLECULAR LIBRARY;

MURINAE; MUS;

ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; COMBINATORIAL CHEMISTRY TECHNIQUES; DIABETES MELLITUS, TYPE 1; GLUTAMATE DECARBOXYLASE; HUMANS; IMMUNOGLOBULIN G; MICE; MICE, INBRED NOD; MOLECULAR STRUCTURE; OXYGENASES; SMALL MOLECULE LIBRARIES;

EID: 84923377113     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb5007618     Document Type: Article

References (46)

1. Balboni, I., Chan, S. M., Kattah, M., Tenenbaum, J. D., Butte, A. J., and Utz, P. J. (2006) Multiplexed protein array platforms for analysis of autoimmune diseases Annu. Rev. Immunol. 24, 391-418
2. Kanter, J. L., Narayana, S., Ho, P. P., Catz, I., Warren, K. G., Sobel, R. A., Steinman, L., and Robinson, W. H. (2006) Lipid microarrays identify key mediators of autoimmune brain inflammation Nature Med. 12, 138-143
3. Wang, X., Yu, J.-Q., Sreekumar, A., Varambally, S., Shen, R., Giachero, D., Mehra, R., Montie, J. E., Pienta, K. J., Sanda, M. G., Kantoff, P. W., Rubin, M. A., Wei, J. T., Ghosh, D., and Chinnaiyan, A. M. (2005) Autoantibody signatures in prostate cancer N. Engl. J. Med. 355, 16-27
4. Raveendra, B., Hao, W., Baccala, R., Reddy, M. M., Schilke, J., Bennett, J. L., Theofiliopolous, A. N., and Kodadek, T. (2013) Discovery of peptoid ligands for anti-Aquaporin 4 antibodies Chem. Biol. 20, 350-359
5. Reddy, M. M., Wilson, R., Wilson, J., Connell, S., Gocke, A., Hynan, L., German, D., and Kodadek, T. (2011) Identification of candidate IgG biomarkers for Alzheimers Disease via combinatorial library screening Cell 144, 132-142
6. Knittelfelder, R., Riemer, A. B., and Jensen-Jarolim, E. (2009) Mimotope vaccination - from allergy to cancer Expert Opin. Biol. Ther. 9, 493-506
7. Eisenbarth, G. S. (1986) Type I diabetes mellitus. A chronic autoimmune disease N. Eng. J. Med. 314, 1360-1368
8. Herold, K. C., Vignali, D. A., Cooke, A., and Bluestone, J. A. (2013) Type 1 diabetes: translating mechanistic observations into effective clinical outcomes Nature Rev. 13, 243-256
9. Baekkeskov, S., Aanstoot, H. J., Christgau, S., Reetz, A., Solimena, M., Cascalho, M., Folli, F., Richter-Olesen, H., and De Camilli, P. (1990) Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase Nature 347, 151-156
10. Kawasaki, E., Eisenbarth, G. S., Wasmeier, C., and Hutton, J. C. (1996) Autoantibodies to protein tyrosine phosphatase-like proteins in type I diabetes. Overlapping specificities to phogrin and ICA512/IA-2 Diabetes 45, 1344-1349
11. Lu, J., Li, Q., Xie, H., Chen, Z. J., Borovitskaya, A. E., Maclaren, N. K., Notkins, A. L., and Lan, M. S. (1996) Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment Proc. Natl. Acad. Sci. U. S. A. 93, 2307-2311
12. Passini, N., Larigan, J. D., Genovese, S., Appella, E., Sinigaglia, F., and Rogge, L. (1995) The 37/40-kilodalton autoantigen in insulin-dependent diabetes mellitus is the putative tyrosine phosphatase IA-2 Proc. Natl. Acad. Sci. U. S. A. 92, 9412-9416
13. Bonifacio, E., Lampasona, V., Genovese, S., Ferrari, M., and Bosi, E. (1995) Identification of protein tyrosine phosphatase-like IA2 (islet cell antigen 512) as the insulin-dependent diabetes-related 37/40K autoantigen and a target of islet-cell antibodies J. Immunol. 155, 5419-5426
14. Lan, M. S., Wasserfall, C., Maclaren, N. K., and Notkins, A. L. (1996) IA-2, a transmembrane protein of the protein tyrosine phosphatase family, is a major autoantigen in insulin-depedent diabetes mellitus Proc. Natl. Acad. Sci. U.S.A. 93, 2307-2311
15. Wenzlau, J. M., Juhl, K., Yu, L., Moua, O., Sarkar, S. A., Gottlieb, P., Rewers, M., Eisenbarth, G. S., Jensen, J., Davidson, H. W., and Hutton, J. C. (2007) The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes Proc. Natl. Acad. Sci. U. S. A. 104, 17040-17045
16. Anderson, M. S. and Bluestone, J. A. (2005) The NOD mouse: a model of immune dysregulation Annu. Rev. Immunol. 23, 447-485
17. Simon, R. J., Kania, R. S., Zuckermann, R. N., Huebner, V. D., Jewell, D. A., Banville, S., Ng, S., Wang, L., Rosenberg, S., and Marlowe, C. K. 1992, Peptoids: a modular approach to drug discovery Proc. Natl. Acad. Sci. U. S. A. 89, 9367-9371
18. Velloso, L. A., Eizirik, D. L., Karlsson, F. A., and Kampe, O. (1994) Absence of autoantibodies against glutamate decarboxylase (GAD) in the non-obese diabetic (NOD) mouse and low expression of the enzyme in mouse islets Clin. Exp. Imunol. 96, 129-137
19. Bieg, S., Seissler, J., Herberg, L., Northemann, W., and Scherbaum, W. A. (1994) GAD65 is recognized by T-cells, but not by antibodies from NOD-mice Autoimmunity 17, 189-194
20. Mackay, I. R., Bone, A., Tuomi, T., Elliott, R., Mandel, T., Karopoulos, C., and Rowley, M. J. (1996) Lack of autoimmune serological reactions in rodent models of insulin dependent diabetes mellitus J. Autoimmun. 9, 705-711
21. Bonifacio, E., Atkinson, M., Eisenbarth, G., Serreze, D., Kay, T. W., Lee-Chan, E., and Singh, B. (2001) International Workshop on Lessons From Animal Models for Human Type 1 Diabetes: identification of insulin but not glutamic acid decarboxylase or IA-2 as specific autoantigens of humoral autoimmunity in nonobese diabetic mice Diabetes 50, 2451-2458
22. Yu, L., Robles, D. T., Abiru, N., Kaur, P., Rewers, M., Kelemen, K., and Eisenbarth, G. S. (2000) Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes Proc. Natl. Acad. Sci. U. S. A. 97, 1701-1706
23. Figliozzi, G. M., Goldsmith, R., Ng, S. C., Banville, S. C., and Zuckermann, R. N. (1996) Synthesis of N-substituted glycine peptoid libraries Methods Enzymol. 267, 437-447
24. Alluri, P. G., Reddy, M. M., Bachhawat-Sikder, K., Olivos, H. J., and Kodadek, T. (2003) Isolation of protein ligands from large peptoid libraries J. Am. Chem. Soc. 125, 13995-14004
25. Lam, K. S., Salmon, S. E., Hersh, E. M., Hruby, V. J., Kazmierski, W. M., and Knapp, R. J. (1991) A new type of synthetic peptide library for identifying ligand-binding activity Nature 354, 82-84
26. Olivos, H. J., Baccawat-Sikder, K., and Kodadek, T. (2003) Quantum dots as a visual aid for screening bead-bound combinatorial libraries ChemBiochem 4, 1242-1245
27. Doran, T. M., Gao, Y., Mendes, K., Dean, S., Simanski, S., and Kodadek, T. (2014) The utility of redundant combinatorial libraries in distinguishing high and low quality screening hits ACS Comb. Sci. 16, 259-270
28. Racke, M. K. (2001) Experimental autoimmune encephalomyelitis (EAE), Current Protocols in Neuroscience (Crawley, J. N., Eds.), Chapter 9, Unit 9.7, John Wiley & Sons, New York.
29. Doran, T. M. and Kodadek, T. (2013) A Liquid Array Platform for the Multiplexed Analysis of Synthetic Molecule-Protein Interactions ACS Chem. Biol. 9, 339-346
30. Abiru, N., Yu, L., Miao, D., Maniatis, A. K., Liu, E., Moriyama, H., and Eisenbarth, G. S. (2001) Transient insulin autoantibody expression independent of development of diabetes: comparison of NOD and NOR strains J. Autoimmun. 17, 1-6
31. Zeng, F. Y., Oka, J. A., and Weigel, P. H. (1996) Renaturation and ligand blotting of the major subunit of the rat asialoglycoprotein receptor after denaturing polyacrylamide gel electrophoresis Glycobiology 6, 247-255
32. Kim, J., Richter, W., Aanstoot, H. J., Shi, Y., Fu, Q., Rajotte, R., Warnock, G., and Baekkeskov, S. (1993) Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets Diabetes 42, 1799-1808
33. Pleau, J. M., Esling, A., Bach, J. F., and Dardenne, M. (1996) Gene expression of pancreatic glutamic acid decarboxylase in the nonobese diabetic mouse Biochem. Biophys. Res. Commun. 220, 399-404
34. Petersen, J. S., Hejnaes, K. R., Moody, A., Karlsen, A. E., Marshall, M. O., Hoier-Madsen, M., Boel, E., Michelsen, B. K., and Dyrberg, T. (1994) Detection of GAD65 antibodies in diabetes and other autoimmune diseases using a simple radioligand assay Diabetes 43, 459-467
35. Bonifacio, E., Lampasona, V., Bernasconi, L., and Ziegler, A. G. (2000) Maturation of the humoral autoimmune response to epitopes of GAD in preclinical childhood type 1 diabetes Diabetes 49, 202-208
36. Velloso, L. A., Kampe, O., Hallberg, A., Christmanson, L., Betsholtz, C., and Karlsson, F. A. (1993) Demonstration of GAD-65 as the main immunogenic isoform of glutamate decarboxylase in type 1 diabetes and determination of autoantibodies using a radioligand produced by eukaryotic expression J. Clin. Invest. 91, 2084-2090
37. Graham, J., Hagopian, W. A., Kockum, I., Li, L. S., Sanjeevi, C. B., Lowe, R. M., Schaefer, J. B., Zarghami, M., Day, H. L., Landin-Olsson, M., Palmer, J. P., Janer-Villanueva, M., Hood, L., Sundkvist, G., Lernmark, A., Breslow, N., Dahlquist, G., and Blohme, G. (2002) Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes Diabetes 51, 1346-1355 (Diabetes Incidence in Sweden Study, G., and Swedish Childhood Diabetes Study, G)
38. Kanaani, J., Patterson, G., Schaufele, F., Lippincott-Schwartz, J., and Baekkeskov, S. (2008) A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes J. Cell Sci. 121, 437-449
39. Christgau, S., Aanstoot, H. J., Schierbeck, H., Begley, K., Tullin, S., Hejnaes, K., and Baekkeskov, S. (1992) Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain J. Cell Biol. 118, 309-320
40. r Islet Antigen Diabetes 37, 1587-1590
41. Elias, D., Markovits, D., Reshef, T., Zee, R. v. d., and Cohen, I. R. (1990) Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein Proc. Natl. Acad. Sci. U.S.A. 87, 1576-1580
42. Aizpurua, H. J. D., French, M. B., Chosich, N., and Harrison, L. C. (1994) Natural History of Humoral Immunity to Glutamic Acid Decarboxylase in Non-Obese Diabetic (NOD) Mice J. Autoimmun. 7, 643-653
43. Tisch, R., Yang, X.-D., Singer, S. M., Liblau, R. S., Fugger, L., and McDevitt, H. O. (1993) Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice Nature 366, 72-75
44. Miao, D., Guyer, M. S., Dong, F., Jiang, L., Steck, A. K., Rewers, M., Eisenbarth, G. S., and Yu, L. (2013) GAD65 autoantibodies detected by electrochemiluminescence assay identify high risk for type I diabetes Diabetes 62, 4174-4178
45. Yu, L., Dong, F., Miao, D., Fouts, A. R., Wenzlau, J. M., and Steck, A. K. (2013) Proinsulin/Insulin autoantibodies measured with electrochemiluminescent assay are the earliest indicator of prediabetic islet autoimmunity Diabetes Care 36, 2266-2270
46. Zhang, B., Kumar, R. B., Dai, H., and Feldman, B. J. (2014) A plasmonic chip for biomarker discovery and diagnosis of type 1 diabetes Nature Med. 20, 948-953