Lack of autoimmune serological reactions in rodent models of insulin dependent diabetes mellitus

Journal of Autoimmunity

Volumn 9, Issue 6, 1996, Pages 705-711

  Mackay, I R ^a   Bone, A ^b   Tuomi, T ^a   Elliott, R ^d   Mandel, T ^c   Karopoulos, C ^a   Rowley, M J ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF BRIGHTON   (United Kingdom)

^c WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d NONE

Author keywords

anti GAD; anti insulin; autoantibodies; autoimmunity; insulin dependent diabetes; rodent models

Indexed keywords

AUTOANTIBODY; GLUTAMATE DECARBOXYLASE; INSULIN ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; ETIOLOGY; FEMALE; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT;

EID: 0030449310     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1996.0092     Document Type: Article

References (50)

1. 1. Castano L., Eisenbarth G.S. 1990. Type 1 diabetes: a chronic autoimmune disease of human, mouse and rat. Annu. Rev. Immunol. 8: 437-441
2. 2. Logothetopoulos J., Valiquette N., Madura E., Cvet D. 1984. The onset and progression of pancreatic insulitis in the overt, spontaneously diabetic young adult BB rat studies by pancreatic biopsy. Diabetes 33: 33-36
3. 3. Bernard C.C.A., Mandel T.E., Mackay I.R. 1992. Experimental models of human autoimmune disease: overview and prototypes. In The Autoimmune Diseases, II, Rose NR, Mackay IR eds. Academic Press, San Diego, pp 47-106
4. 4. Jackson R.A., Buse J.B., Rifai R., Pelletier D., Milford E.L., Carpenter C.B., Eisenbarth G.S., Williams R.M. 1984. Two genes required for diabetes in BB rats. Evidence from cyclical intercrosses and backcrosses. J. Exp. Med. 159: 1629-1630
5. 5. Wicker L.S., Todd J.A., Peterson L.B. 1995. Genetic control of autoimmune diabetes in the NOD mouse. Annu. Rev. Immunol. 13: 179-200
6. 6. Harrison L.C., Honeyman M.C., DeAizpurua H.J., Schmidli R.S., Colman P.G., Tait B.D., Cram D.S. 1993. Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes. Lancet 341: 1365-1369
7. 7. Elias D., Markovits D., Reschef T., Van der Zee R., Cohen I.R. 1990. Induction and therapy of autoimmune diabetes in the non-obese diabetic mouse by a 65 kDa heat shock protein. Proc. Natl. Acad. Sci. USA 87: 1576-1580
8. 8. Renold A.E., Porte D., Shafrir E. 1988. Definitions for diabetes types: use and abuse of the concept of 'animal models of diabetes mellitus'. In Frontiers of Diabetes Research. Lessons from Animal Diabetes, Shafrir E, Renold AE eds. J Libbery & Co, pp 3-7
9. 9. Bone A., Unpublished data
10. 10. Baxter A.G., Koulmanda M., Mandel T.E. 1991. High and low diabetes incidence in non-obese diabetic (NOD) mice: origins and characterization. Autoimmunity 9: 61-67
11. 11. Gottlieb D.I., Chang Y.C., Schwob J.E. 1986. Monoclonal antibodies to glutamic acid decarboxylase. Proc. Natl. Acad. Sci. USA 83: 8008-8012
12. 12. Rowley M.J., Mackay I.R., Chen Q.-Y., Knowles W.J., Zimmet P.Z. 1992. Antibodies to glutamic acid decarboxylase discriminate major types of diabetes mellitus. Diabetes 41: 548-551
13. 13. Chen Q.-Y., Rowley M.J., Byrne G.C., Jones T., Tuomi T., Knowles W.J., Zimmet P.Z., Mackay I.R. 1993. Antibodies to glutamic acid decarboxylase in Australian children with insulin dependent diabetes mellitus and their first degree relatives. Pediatric Res. 34: 785-790
14. 14. Myers M.A., Mackay I.R., Zimmet P.Z., Rowley M.J. 1996. Autoantibodies to glutamate decarboxylase in insulin dependent diabetes mellitus. Diabetes Annual 10 (in press)
15. 15. Schmidli R.S., Colman P.G., Bonifacio E., and participating laboratories. 1995. Disease sensitivity and specificity of 52 assays for glutamic acid decarboxylase antibodies. The second international GADAb workshop. Diabetes 44: 636-640
16. 16. Vardi P., Dib S.A., Tuttleman M., Connelly J.E., Grinbergs M., Radizabeh A. et al. 1987. Competitive insulin autoantibody assay. Prospective evaluation of subjects at high risk for development of Type 1 diabetes mellitus. Diabetes 36: 1286-1291
17. 17. Zimmet P.Z., Elliot R.B., Mackay I.R., Tuomi T., Rowley M.J., Pilcher C.C., Knowles W.J. 1993. Autoantibodies to glutamic acid decarboxylase and insulin in islet cell antibody positive presymptomatic Type 1 diabetes mellitus: frequency and segregation by age and gender. Diabetic Medicine 11: 866-871
18. 18. Karopoulos C., Rowley M.J., Handley C.J., Strugnell R.A. 1995. Antibody reactivity to mycobacterial 65 kDa heat shock protein: relevance to autoimmunity. J. Autoimmunity 8: 235-248
19. 19. Crisá L., Mordes J.P., Rossini A.A. 1992. Autoimmune diabetes mellitus in the BB rat. Diabetes Metab. Rev. 8: 9-37
20. 20. Like A.A., Appel M.C., Rossini A.A. 1982. Autoantibodies in the BB/W rat. Diabetes 31: 816-820
21. 21. Elder M., Maclaren N., Riley W., McConnell T. 1982. Gastric parietal cell and other autoantibodies in the BB rat. Diabetes 31: 313-316
22. 22. Pollard D.R., Gupta A., Mancino L., Hynie I. 1983. An immunofluorescence study of anti-pancreatic islet cell antibodies in the spontaneously diabetic BB Wistar rat. Diabetologia 25: 56-59
23. 23. Dyrberg T., Poussier P., Nakhooda A.F., Baekkeskov S., Marliss E.B., Lernmark A. 1984. Islet cell surface and lymphocyte antibodies often precede the spontaneous diabetes in the BB rat. Diabetologia 26: 159-165
24. 24. Martin D.R., Logothetopoulos J. 1984. Complement-fixing islet cell antibodies in the spontaneously diabetic BB rat. Diabetes 33: 93-96
25. 25. Laborie C., Sai P., Feutren G., Debray-Sachs M., Quiniou-Debrie M.C., Poussier P., Marliss E.B., Assan R. 1985. Time course of islet cell antibodies in diabetic and nondiabetic BB rats. Diabetes 34: 904-910
26. 26. Pipeleers D., van de Winkel M., Dyrberg T., Lernmark A. 1987. Spontaneously diabetic BB rats have age-dependent islet ß-cell-specific surface antibodies at clinical onset. Diabetes 36: 1111-1115
27. 27. Dean B.M., Bone A.J., Varey A.M., Walker R., Baird J.D., Book A. 1987. Insulin autoantibodies, islet cell surface antibodies and the development of spontaneous diabetes in the BB/Edinburgh rat. Clin. Exp. Immunol. 69: 308-313
28. 28. Ko I.Y., Jun H.S., Kim G.S., Yoon J.W. 1994. Studies on autoimmunity for initiation of beta-cell destruction X. Delayed expression of a membrane-bound islet-cell specific 38 kDa autoantigen that precedes insulitis and diabetes in the diabetes-prone BB rat. Diabetologia 37: 460-465
29. 29. Wilkin T., Kiesel U., Diaz J.-L., Burkart V., Kolb H. 1986. Autoantibodies to insulin as serum markers for autoimmune insulitis. Diabetes Res. 3: 173-174
30. 30. Markholst H., Klaff L.J., Klöppel G., Lernmark A., Mordes J.P., Palmer J. 1990. Lack of systematically found insulin autoantibodies in spontaneously diabetic BB rats. Diabetes 39: 720-727
31. 31. Baekkeskov S., Dyrberg T., Lernmark A. 1984. Autoantibodies to the 64 kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat. Science 224: 1348-1350
32. 32. Ziegler K., Schlosser M., Hamann J., Vieregge P., Lühder F., Klöting I., Ziegler B. 1994. Autoantibodies to glutamate decarboxylase detected in diabetes-prone BB/OK rats do not distinguish onset of diabetes. Exp. Clin. Endocrinol. 102: 98-103
33. 33. Davenport C., Lovell H., James R.F.L., Todd I. 1995. Brain-reactive autoantibodies in BB/d rats do not recognize glutamic acid decarboxylase. Clin. Exp. Immunol. 101: 127-135
34. 34. Elias D., Markovits D., Reshef T., van der Zee R., Cohen I.R. 1990. Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse. Proc. Natl. Acad. Sci. USA 87: 1576-1580
35. 35. Shafir E. 1991. Animals with diabetes: Progress in the understanding of diabetes through study of its pathogenesis in animal models. Diabetes Annual 6: 634-663.
36. 36. Pontesilli O., Carotenuto P., Gazda L.S., Pratt P.F., Prowse S.J. 1987. Circulating lymphocyte populations and autoantibodies in non-obese diabetic (NOD) mice: a longitudinal study. Clin. Exp. Immunol. 70: 84-93
37. 37. Reddy S., Bibby N., Elliott R.B. 1990. Longitudinal study of islet cell antibodies and insulin autoantibodies and development of diabetes in non-obese diabetic (NOD) mice. Clin. Exp. Immunol. 81: 400-405
38. 38. Kanazawa Y., Komeda K., Sato S., Mori S., Akanuma K., Takaku F. 1984. Non-obese-diabetic mice: immune mechanisms of pancreatic β-cell destruction. Diabetologia 27: 113-115
39. 39. Maruyama T., Takei I., Yanagawa T., Takahashi T., Asaba Y., Kataoka K., Ishii T. 1988. Insulin autoantibodies in non-obese diabetic (NOD) mice and streptozotocin-induced diabetic mice. Diabetes Res. 7: 93-96
40. 40. Serreze D.V., Leiter E.H., Kuff E.L., Jardieu P., Ishizaka K. 1988. Molecular mimicry between insulin and retroviral antigen p73: development of cross-reactive autoantibodies in sera of NOD and C57Bl/KsJ db/db mice. Diabetes 37: 351-358
41. 41. Ziegler A.G., Vardi P., Ricker A.T., Hattori M., Soeldner J.S., Eisenbarth G.S. 1989. Radioassay determination of insulin autoantibodies in NOD mice. Diabetes 38: 358-363
42. 42. Michel C., Boitard C., Bach J.-F. 1989. Insulin autoantibodies in non-obese diabetic (NOD) mice. Clin. Exp. Immunol. 75: 457-460
43. 43. Atkinson M.A., Maclaren N.K. 1988. Autoantibodies in non-obese diabetic mice immunoprecipitate a 64,000-Mr antigen. Diabetes 37: 1587-1590
44. 44. De Aizpurua H.J., French M.B., Chosich N., Harrison L.C. 1994. Natural history of humoral immunity to glutamic acid decarboxylase in non-obese diabetic (NOD) mice. J. Autoimmunity 7: 643-653
45. 45. Tisch R., Yang X.D., Singer S.M., Libiau R.S., Fugger L., McDevitt H.O. 1993. Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice. Nature 366: 72-75
46. 46. Velloso L.A., Eizirck D.L., Karlsson F.A., Kämpe O. 1994. Absence of autoantibodies against glutamate decarboxylase (GAD) in the NOD mouse and low expression of the enzyme in mouse islets. Clin. Exp. Immunol. 96: 129-137
47. 47. Kim J., Richter W., Aanstoot H.-J., Shi Y., Fu Q., Rajotte R., Warnock G., Baekkeskov S. 1993. Differential expression of GAD65 and GAD67 in human, rat, and mouse pancreatic islets. Diabetes 42: 1799-1808
48. 48. Bieg S., Seissler J., Herberg G., Northmann W., Scherbaum W.A. 1994. GAD65 is recognized by T-cells, but not by antibodies from NOD-mice. Autoimmmunity 17: 189-194
49. 49. Prud'homme G.J., Colle E., Fuks A., Goldner-Sauvé A., Guttman R.D. 1985. Cellular immune abnormalities and autoreactive T lymphocytes in insulin-dependent diabetes mellitus in rats. Immunol. Today 6: 160-162
50. 50. Kaufman D.L., Clare-Salzer M., Tian J., Forsthuber T., Tiug G.S.P., Robinson P., Atkinson M.A., Sercarz E.E., Tobin A.J., Lehmann P.V. 1993. Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366: 69-72.