Detection of cell aggregation and altered cell viability by automated label-free video microscopy: A promising alternative to endpoint viability assays in high-throughput screening

Journal of Biomolecular Screening

Volumn 20, Issue 3, 2015, Pages 372-381

  Aftab, Obaid ^a   Fryknäs, Mårten ^a   Hammerling, Ulf ^a   Larsson, Rolf ^a   Gustafsson, Mats G ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

cell aggregation; differentially time evolving morphologies; high throughput screening (HTS); PDGFR signaling; phase contrast microscopy; time lapse microscopy; video microscopy

Indexed keywords

ANCITABINE; COLCHICINE; DASATINIB; IMATINIB; PLATELET DERIVED GROWTH FACTOR RECEPTOR; VANDETANIB; MOLECULAR LIBRARY;

ARTICLE; AUTOMATED QUANTIFICATION OF DIFFERENTIALLY TIME EVOLVING MORPHOLOGY; CANCER SCREENING; CANCER SURVIVAL; CELL AGGREGATION; CELL POPULATION; CELL VIABILITY ASSAY; CHEMICAL PARAMETERS; COLORECTAL CARCINOMA; CONTROLLED STUDY; HCT116 CELL LINE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; LIMIT OF QUANTITATION; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; VIDEO MICROSCOPY; ALGORITHM; CELL SURVIVAL; CLUSTER ANALYSIS; DRUG DEVELOPMENT; DRUG EFFECTS; MOLECULAR LIBRARY; MULTICELLULAR SPHEROID; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; TUMOR CELL LINE;

ALGORITHMS; CELL AGGREGATION; CELL LINE, TUMOR; CELL SURVIVAL; CLUSTER ANALYSIS; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICROSCOPY, PHASE-CONTRAST; MICROSCOPY, VIDEO; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SMALL MOLECULE LIBRARIES; SPHEROIDS, CELLULAR;

EID: 84923348007     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057114562158     Document Type: Article

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