Development of a SPE-UHPLC-MS/MS methodology for the determination of non-steroidal anti-inflammatory and analgesic pharmaceuticals in seawater

Journal of Pharmaceutical and Biomedical Analysis

Volumn 106, Issue , 2015, Pages 61-70

  Paíga, Paula ^a   Lolić, Aleksandar ^a,b   Hellebuyck, Floris ^a   Santos, Lúcia H M L M ^a,c   Correia, Manuela ^a   Delerue Matos, Cristina ^a  

^a INSTITUTO SUPERIOR DE ENGENHARIA DO PORTO   (Portugal)

^b UNIVERSITY OF BELGRADE   (Serbia)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

Analgesics; Non steroidal anti inflammatory drugs; Seawater; SPE; UHPLC MS MS

Indexed keywords

2 [4 (2 CARBOXYPROPYL)PHENYL]PROPIONIC ACID; ACETYLSALICYLIC ACID; AMINOPHENOL; ANALGESIC AGENT; DICLOFENAC; DIPYRONE; DRUG METABOLITE; HYDROXYIBUPROFEN; IBUPROFEN; KETOPROFEN; NAPROXEN; NIMESULIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PARACETAMOL; PARACETAMOL GLUCURONIDE; SEA WATER; UNCLASSIFIED DRUG; WATER POLLUTANT;

ARTICLE; ATLANTIC OCEAN; DRUG DETERMINATION; LIMIT OF DETECTION; PH; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROCEDURES; VALIDATION STUDY; WATER POLLUTANT;

ANALGESICS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; SEAWATER; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; WATER POLLUTANTS, CHEMICAL;

EID: 84923327567     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2014.06.017     Document Type: Article

References (37)

1. Kümmerer K. The presence of pharmaceuticals in the environment due to human use - present knowledge and future challenges. J. Environ. Manage. 2009, 90:2354-2366.
2. Hoshina K., Horiyama S., Matsunaga H., Haginaka J. Simultaneous determination of non-steroidal anti-inflammatory drugs in river water samples by liquid chromatography-tandem mass spectrometry using molecularly imprinted polymers as a pretreatment column. J. Pharm. Biomed. Anal. 2011, 55:916-922.
3. Gracia-Lor E., Sancho J.V., Serrano R., Hernández F. Occurrence and removal of pharmaceuticals in wastewater treatment plants at the Spanish Mediterranean area of Valencia. Chemosphere 2012, 87:453-462.
4. Fram M.S., Belitz K. Occurrence and concentrations of pharmaceutical compounds in groundwater used for public drinking-water supply in California. Sci. Total Environ. 2011, 409:3409-3417.
5. Bragança I., Plácido A., Paíga P., Domingues V.F., Delerue-Matos C. QuEChERS: a new sample preparation approach for the determination of ibuprofen and its metabolites in soils. Sci. Total Environ. 2012, 433:281-289.
6. Benotti M.J., Trenholm R.A., Vanderford B.J., Holady J.C., Stanford B.D., Snyder S.A. Pharmaceuticals and endocrine disrupting compounds in US drinking water. Environ. Sci. Technol. 2009, 43:597-603.
7. Christensen F.M. Pharmaceuticals in the environment - a human risk?. Regul. Toxicol. Pharm. 1998, 28:212-221.
8. Cleuvers M. Mixture toxicity of the anti-inflammatory drugs diclofenac, ibuprofen, naproxen, and acetylsalicylic acid. Ecotoxicol. Environ. Saf. 2004, 59:309-315.
9. Schwaiger J., Ferling H., Mallow U., Wintermayr H., Negele R.D. Toxic effects of the non-steroidal anti-inflammatory drug diclofenac: Part I. Histopathological alterations and bioaccumulation in rainbow trout. Aquat. Toxicol. 2004, 68:141-150.
10. Triebskorn R., Casper H., Heyd A., Eikemper R., Kohler H.R., Schwaiger J. Toxic effects of the non-steroidal anti-inflammatory drug diclofenac: Part II. Cytological effects in liver, kidney, gills and intestine of rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 2004, 68:151-166.
11. Flippin J.L., Huggett D., Foran C.M. Changes in the timing of reproduction following chronic exposure to ibuprofen in Japanese medaka, Oryzias latipes. Aquat. Toxicol. 2007, 81:73-78.
12. Directive 2013/39/EU amending directives 2000/60/EC and 2008/105/EC as regards priority substances in the field of water policy Off. J. Eur. Union 2013, L226:1-17.
13. Farré M., Kantiani L., Petrovic M., Pérez S., Barceló D. Achievements and future trends in the analysis of emerging organic contaminants in environmental samples by mass spectrometry and bioanalytical techniques. J. Chromatogr. A 2012, 1259:86-99.
14. Petrovic M., Farré M., de Alda M.L., Perez S., Postigo C., Köck M., Radjenovic J., Gros M., Barceló D. Recent trends in the liquid chromatography-mass spectrometry analysis of organic contaminants in environmental samples. J. Chromatogr. A 2010, 1217:4004-4017.
15. Guillarme D., Ruta J., Rudaz S., Veuthey J.L. New trends in fast and high-resolution liquid chromatography: a critical comparison of existing approaches. Anal. Bioanal. Chem. 2010, 397:1069-1082.
16. Buchberger W.W. Current approaches to trace analysis of pharmaceuticals and personal care products in the environment. J. Chromatogr. A 2011, 1218:603-618.
17. Pavlovic D.M., Babic S., Horvat A.J.M., Kastelan-Macan M. Sample preparation in analysis of pharmaceuticals. TrAC Trends Anal. Chem. 2007, 26:1062-1075.
18. Weigel S., Bester K., Hühnerfuss H. New method for rapid solid-phase extraction of large-volume water samples and its application to non-target screening of North Sea water for organic contaminants by gas chromatography-mass spectrometry. J. Chromatogr. A 2001, 912:151-161.
19. Nödler K., Licha T., Bester K., Sauter M. Development of a multi-residue analytical method, based on liquid chromatography-tandem mass spectrometry, for the simultaneous determination of 46 micro-contaminants in aqueous samples. J. Chromatogr. A 2010, 1217:6511-6521.
20. Gros M., Rodríguez-Mozaz S., Barceló D. Fast and comprehensive multi-residue analysis of a broad range of human and veterinary pharmaceuticals and some of their metabolites in surface and treated waters by ultra-high-performance liquid chromatography coupled to quadrupole-linear ion trap tandem mass spectrometry. J. Chromatogr. A 2012, 1248:104-121.
21. Borecka M., Bialk-Bielinska A., Siedlewicz G., Kornowska K., Kumirska J., Stepnowski P., Pazdro K. A new approach for the estimation of expanded uncertainty of results of an analytical method developed for determining antibiotics in seawater using solid-phase extraction disks and liquid chromatography coupled with tandem mass spectrometry technique. J. Chromatogr. A 2013, 1304:138-146.
22. Wille K., Noppe H., Verheyden K., Vanden Bussche J., De Wulf E., Van Caeter P., Janssen C.R., De Brabander H.F., Vanhaecke L. Validation and application of an LC-MS/MS method for the simultaneous quantification of 13 pharmaceuticals in seawater. Anal. Bioanal. Chem. 2010, 397:1797-1808.
23. Rodriguez-Navas C., Bjoerklund E., Bak S.A., Hansen M., Krogh K.A., Maya F., Forteza R., Cerda V. Pollution pathways of pharmaceutical residues in the aquatic environment on the island of Mallorca, Spain. Arch. Environ. Contam. Toxicol. 2013, 65:56-66.
24. Wu J., Qian X., Yang Z., Zhang L. Study on the matrix effect in the determination of selected pharmaceutical residues in seawater by solid-phase extraction and ultra-high-performance liquid chromatography-electrospray ionization low-energy collision-induced dissociation tandem mass spectrometry. J. Chromatogr. A 2010, 1217:1471-1475.
25. INFARMED Estatística do Medicamento 2012, INFARMED.
26. Santos L.H.M.L., Gros M., Rodriguez-Mozaz S., Delerue-Matos C., Pena A., Barceló D., Montenegro M.C.B.S. Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: identification of ecologically relevant pharmaceuticals. Sci. Total Environ. 2013, 461/462:302-310.
27. Paíga P., Santos L.M.L.M., Amorim C., Araújo A., Montenegro M.C.S.M., Pena A., Delerue-Matos C. Pilot monitoring study of ibuprofen in surface waters of north of Portugal. Environ. Sci. Pollut. Res. 2013, 20:2410-2420.
28. (accessed 15.02.14). http://www.chemicalize.org/.
29. Ferrando-Climent L., Collado N., Buttiglieri G., Gros M., Rodriguez-Roda I., Rodriguez-Mozaz S., Barceló D. Comprehensive study of ibuprofen and its metabolites in activated sludge batch experiments and aquatic environment. Sci. Total Environ. 2012, 438:404-413.
30. British Pharmacopeia on-line, (accessed 27.01.14). http://bp2012.infostar.com.cn/.
31. Directive 2006/07/EC concerning the management of bathing water quality and repealing directive 76/160/EEC. Off. J. Eur. Union 2006, L64:37-51.
32. Gros M., Petrovic M., Barceló D. Development of a multi-residue analytical methodology based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for screening and trace level determination of pharmaceuticals in surface and wastewaters. Talanta 2006, 70:678-690.
33. Petrovic M., Hernando M.D., Díaz-Cruz M.S., Barceló D. Liquid chromatography-tandem mass spectrometry for the analysis of pharmaceutical residues in environmental samples: a review. J. Chromatogr. A 2005, 1067:1-14.
34. Fontanals N., Cormack P.A.G., Marce R.M., Borrull F. Mixed-mode ion-exchange polymeric sorbents: dual-phase materials that improve selectivity and capacity. TrAC Trends Anal. Chem. 2010, 29:765-779.
35. Fontanals N., Marce R.M., Borrull F. New materials in sorptive extraction techniques for polar compounds. J. Chromatogr. A 2007, 1152:14-31.
36. Djukovic D., Appiah-Amponsah E., Shanaiah N., Gowda G.A.N., Henry I., Everly M., Tobias B., Raftery D. Ibuprofen metabolite profiling using a combination of SPE/column-trapping and HPLC-micro-coil NMR. J. Pharm. Biomed. Anal. 2008, 47:328-334.
37. Weigel S., Berger U., Jensen E., Kallenborn R., Thoresen H., Hühnerfuss H. Determination of selected pharmaceuticals and caffeine in sewage and seawater from Tromsø/Norway with emphasis on ibuprofen and its metabolites. Chemosphere 2004, 56:583-592.