Molecular epidemiological characteristics of Klebsiella pneumoniae associated with bacteremia among patients with pneumonia

Journal of Clinical Microbiology

Volumn 53, Issue 3, 2015, Pages 879-886

  Ito, Ryota ^a   Shindo, Yuichiro ^a,b   Kobayashi, Daisuke ^a   Ando, Masahiko ^c   Jin, Wanchun ^a   Wachino, Jun Ichi ^a   Yamada, Keiko ^a   Kimura, Kouji ^a   Yagi, Tetsuya ^c   Hasegawa, Yoshinori ^a   Arakawa, Yoshichika ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

^c NAGOYA UNIVERSITY HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM IDENTIFICATION; BACTERIUM ISOLATE; COMORBIDITY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; FEMALE; GENE FREQUENCY; HUMAN; KLEBSIELLA PNEUMONIAE INFECTION; MAJOR CLINICAL STUDY; MALE; MOLECULAR EPIDEMIOLOGY; MULTILOCUS SEQUENCE TYPING; OBSERVATIONAL STUDY; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; SYSTOLIC BLOOD PRESSURE; VENTILATOR ASSOCIATED PNEUMONIA; VISCOSITY; BACTEREMIA; CLASSIFICATION; COMPLICATION; GENETICS; GENOTYPE; ISOLATION AND PURIFICATION; JAPAN; KLEBSIELLA PNEUMONIAE; MICROBIOLOGY; MIDDLE AGED; PNEUMONIA, BACTERIAL; VERY ELDERLY;

KLEBSIELLA PNEUMONIAE;

VIRULENCE FACTOR;

AGED; AGED, 80 AND OVER; BACTEREMIA; FEMALE; GENOTYPE; HUMANS; JAPAN; KLEBSIELLA PNEUMONIAE; MALE; MIDDLE AGED; MOLECULAR EPIDEMIOLOGY; MULTILOCUS SEQUENCE TYPING; PHENOTYPE; PNEUMONIA, BACTERIAL; VIRULENCE FACTORS;

EID: 84923326307     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.03067-14     Document Type: Article

References (42)

1. Podschun R, Ullmann U. 1998. Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev 11:589-603.
2. Ko WC, Paterson DL, Sagnimeni AJ, Hansen DS, Von Gottberg A, Mohapatra S, Casellas JM, Goossens H, Mulazimoglu L, Trenholme G, Klugman KP, McCormack JG, Yu VL. 2002. Community-acquired Klebsiella pneumoniae bacteremia: global differences in clinical patterns. Emerg Infect Dis 8:160-166. http://dx.doi.org/10.3201/eid0802.010025.
3. Mizuta K, Ohta M, Mori M, Hasegawa T, Nakashima I, Kato N. 1983. Virulence for mice of Klebsiella strains belonging to the O1 group: relationship to their capsular (K) types. Infect Immun 40:56-61.
4. Fang CT, Chuang YP, Shun CT, Chang SC, Wang JT. 2004. A novel virulence gene in Klebsiella pneumoniae strains causing primary liver abscess and septic metastatic complications. J Exp Med 199:697-705. http://dx.doi.org/10.1084/jem.20030857.
5. Yu WL, Ko WC, Cheng KC, Lee HC, Ke DS, Lee CC, Fung CP, Chuang YC. 2006. Association between rmpA and magA genes and clinical syndromes caused by Klebsiella pneumoniae in Taiwan. Clin Infect Dis 42:1351-1358. http://dx.doi.org/10.1086/503420.
6. Siu LK, Yeh KM, Lin JC, Fung CP, Chang FY. 2012. Klebsiella pneumoniae liver abscess: a new invasive syndrome. Lancet Infect Dis 12:881-887. http://dx.doi.org/10.1016/S1473-3099 (12) 70205-0.
7. Paganin F, Lilienthal F, Bourdin A, Lugagne N, Tixier F, Genin R, Yvin JL. 2004. Severe community-acquired pneumonia: assessment of microbial aetiology as mortality factor. Eur Respir J 24:779-785. http://dx.doi.org/10.1183/09031936.04.00119503.
8. Fang CT, Lai SY, Yi WC, Hsueh PR, Liu KL, Chang SC. 2007. Klebsiella pneumoniae genotype K1: an emerging pathogen that causes septic ocular or central nervous system complications from pyogenic liver abscess. Clin Infect Dis 45:284-293. http://dx.doi.org/10.1086/519262.
9. Lin YT, Jeng YY, Chen TL, Fung CP. 2010. Bacteremic communityacquired pneumonia due to Klebsiella pneumoniae: clinical and microbiological characteristics in Taiwan, 2001-2008. BMC Infect Dis 10:307. http://dx.doi.org/10.1186/1471-2334-10-307.
10. Tsay RW, Siu LK, Fung CP, Chang FY. 2002. Characteristics of bacteremia between community-acquired and nosocomial Klebsiella pneumoniae infection: risk factor for mortality and the impact of capsular serotypes as a herald for community-acquired infection. Arch Intern Med 162:1021-1027. http://dx.doi.org/10.1001/archinte.162.9.1021.
11. Enright MC, Spratt BG. 1999. Multilocus sequence typing. Trends Microbiol 7:482-487. http://dx.doi.org/10.1016/S0966-842X (99) 01609-1.
12. Maiden MCJ, Bygraves JA, Feil E, Morelli G, Russell JE, Urwin R, Zhang Q, Zhou JJ, Zurth K, Caugant DA, Feavers IM, Achtman M, Spratt BG. 1998. Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc Natl Acad Sci U S A 95:3140-3145. http://dx.doi.org/10.1073/pnas.95.6.3140.
13. Chung HC, Lai CH, Lin JN, Huang CK, Liang SH, Chen WF, Shih YC, Lin HH, Wang JL. 2012. Bacteremia caused by extended-spectrum-β-lactamase-producing Escherichia coli sequence type ST131 and non-ST131 clones: comparison of demographic data, clinical features, and mortality. Antimicrob Agents Chemother 56:618-622. http://dx.doi.org/10.1128/AAC.05753-11.
14. Brueggemann AB, Griffiths DT, Meats E, Peto T, Crook DW, Spratt BG. 2003. Clonal relationships between invasive and carriage Streptococcus pneumoniae and serotype- and clone-specific differences in invasive disease potential. J Infect Dis 187:1424-1432. http://dx.doi.org/10.1086/374624.
15. Siu LK, Fung CP, Chang FY, Lee N, Yeh KM, Koh TH, Ip M. 2011. Molecular typing and virulence analysis of serotype K1 Klebsiella pneumoniae strains isolated from liver abscess patients and stool samples from noninfectious subjects in Hong Kong, Singapore, and Taiwan. J Clin Microbiol 49:3761-3765. http://dx.doi.org/10.1128/JCM.00977-11.
16. Ruiz M, Ewig S, Marcos MA, Martinez JA, Arancibia F, Mensa J, Torres A. 1999. Etiology of community-acquired pneumonia: impact of age, comorbidity, and severity. Am J Respir Crit Care Med 160:397-405. http://dx.doi.org/10.1164/ajrccm.160.2.9808045.
17. Fine MJ, Smith MA, Carson CA, Mutha SS, Sankey SS, Weissfeld LA, Kapoor WN. 1996. Prognosis and outcomes of patients with communityacquired pneumonia. A meta-analysis. JAMA 275:134-141. http://dx.doi.org/10.1001/jama.1996.03530260048030.
18. Shindo Y, Ito R, Kobayashi D, Ando M, Ichikawa M, Shiraki A, Goto Y, Fukui Y, Iwaki M, Okumura J, Yamaguchi I, Yagi T, Tanikawa Y, Sugino Y, Shindoh J, Ogasawara T, Nomura F, Saka H, Yamamoto M, Taniguchi H, Suzuki R, Saito H, Kawamura T, Hasegawa Y. 2013. Risk factors for drug-resistant pathogens in community-acquired and healthcareassociated pneumonia. Am J Respir Crit Care Med 188:985-995. http://dx.doi.org/10.1164/rccm.201301-0079OC.
19. American Thoracic Society, Infectious Diseases Society of America. 2005. Guidelines for the management of adults with hospital-acquired, ventilatorassociated, and healthcare-associated pneumonia. Am J Respir Crit Care Med 171:388-416. http://dx.doi.org/10.1164/rccm.200405-644ST.
20. Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM, Jr, Musher DM, Niederman MS, Torres A, Whitney CG, Infectious Diseases Society of America, American Thoracic Society. 2007. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of communityacquired pneumonia in adults. Clin Infect Dis 44(Suppl 2):S27-S72. http://dx.doi.org/10.1086/511159.
21. Diancourt L, Passet V, Verhoef J, Grimont PAD, Brisse S. 2005. Multilocus sequence typing of Klebsiella pneumoniae nosocomial isolates. J Clin Microbiol 43:4178-4182. http://dx.doi.org/10.1128/JCM.43.8.4178-4182.2005.
22. Mori M, Ohta M, Agata N, Kido N, Arakawa Y, Ito H, Komatsu T, Kato N. 1989. Identification of species and capsular types of Klebsiella clinical isolates, with special reference to Klebsiella planticola. Microbiol Immunol 33:887-895. http://dx.doi.org/10.1111/j.1348-0421.1989.tb00976.x.
23. Batshon BA, Baer H, Shaffer MF. 1963. Immunologic paralysis produced in mice by Klebsiella pneumoniae type 2 polysaccharide. J Immunol 90:121-126.
24. Brisse S, Fevre C, Passet V, Issenhuth-Jeanjean S, Tournebize R, Diancourt L, Grimont P. 2009. Virulent clones of Klebsiella pneumoniae: identification and evolutionary scenario based on genomic and phenotypic characterization. PLoS One 4:e4982. http://dx.doi.org/10.1371/journal.pone.0004982.
25. Yu WL, Ko WC, Cheng KC, Lee CC, Lai CC, Chuang YC. 2008. Comparison of prevalence of virulence factors for Klebsiella pneumoniae liver abscesses between isolates with capsular K1/K2 and non-K1/K2 serotypes. Diagn Microbiol Infect Dis 62:1-6. http://dx.doi.org/10.1016/j.diagmicrobio.2008.04.007.
26. Meatherall BL, Gregson D, Ross T, Pitout JDD, Laupland KB. 2009. Incidence, risk factors, and outcomes of Klebsiella pneumoniae bacteremia. Am J Med 122:866-873. http://dx.doi.org/10.1016/j.amjmed.2009.03.034.
27. Falguera M, Trujillano J, Caro S, Menendez R, Carratala J, Ruiz-Gonzalez A, Vila M, Garcia M, Porcel JM, Torres A, NAC-CALIDAD (Proyecto Integrado de Investigación de la Sociedad Española de Patología del Aparato Respiratorio sobre Infecciones Respiratorias de Vías Bajas) Study Group. 2009. A prediction rule for estimating the risk of bacteremia in patients with community-acquired pneumonia. Clin Infect Dis 49:409-416. http://dx.doi.org/10.1086/600291.
28. Rello J, Lujan M, Gallego M, Valles J, Belmonte Y, Fontanals D, Diaz E, Lisboa T, PROCORNEU Study Group M. 2010. Why mortality is increased in health-care-associated pneumonia: lessons from pneumococcal bacteremic pneumonia. Chest 137:1138-1144. http://dx.doi.org/10.1378/chest.09-2175.
29. Cryz SJ, Jr, Mortimer PM, Mansfield V, Germanier R. 1986. Seroepidemiology of Klebsiella bacteremic isolates and implications for vaccine development. J Clin Microbiol 23:687-690.
30. Nassif X, Sansonetti PJ. 1986. Correlation of the virulence of Klebsiella pneumoniae K1 and K2 with the presence of a plasmid encoding aerobactin. Infect Immun 54:603-608.
31. Nassif X, Fournier JM, Arondel J, Sansonetti PJ. 1989. Mucoid phenotype of Klebsiella pneumoniae is a plasmid-encoded virulence factor. Infect Immun 57:546-552.
32. Russo TA, Shon AS, Beanan JM, Olson R, MacDonald U, Pomakov AO, Visitacion MP. 2011. Hypervirulent K. pneumoniae secretes more and more active iron-acquisition molecules than "classical" K pneumoniae thereby enhancing its virulence. PLoS One 6:e26734. http://dx.doi.org/10.1371/journal.pone.0026734.
33. Yu VL, Hansen DS, Ko WC, Sagnimeni A, Klugman KP, Von Gottberg A, Goossens H, Wagener MM, Benedi VJ, International Klebsiella Study Group. 2007. Virulence characteristics of Klebsiella and clinical manifestations of K. pneumoniae bloodstream infections. Emerg Infect Dis 13:986-993. http://dx.doi.org/10.3201/eid1307.070187.
34. Uzun O, Akalin HE, Hayran M, Unal S. 1992. Factors influencing prognosis in bacteremia due to Gram-negative organisms: evaluation of 448 episodes in a Turkish university hospital. Clin Infect Dis 15:866-873. http://dx.doi.org/10.1093/clind/15.5.866.
35. Williams BJ, Dehnbostel J, Blackwell TS. 2010. Pseudomonas aeruginosa: host defence in lung diseases. Respirology 15:1037-1056. http://dx.doi.org/10.1111/j.1440-1843.2010.01819.x.
36. Munoz-Price LS, Poirel L, Bonomo RA, Schwaber MJ, Daikos GL, Cormican M, Cornaglia G, Garau J, Gniadkowski M, Hayden MK, Kumarasamy K, Livermore DM, Maya JJ, Nordmann P, Patel JB, Paterson DL, Pitout J, Villegas MV, Wang H, Woodford N, Quinn JP. 2013. Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases. Lancet Infect Dis 13:785-796. http://dx.doi.org/10.1016/S1473-3099 (13) 70190-7.
37. Qureshi ZA, Paterson DL, Potoski BA, Kilayko MC, Sandovsky G, Sordillo E, Polsky B, Adams-Haduch JM, Doi Y. 2012. Treatment outcome of bacteremia due to KPC-producing Klebsiella pneumoniae: superiority of combination antimicrobial regimens. Antimicrob Agents Chemother 56:2108-2113. http://dx.doi.org/10.1128/AAC.06268-11.
38. Zarkotou O, Pournaras S, Tselioti P, Dragoumanos V, Pitiriga V, Ranellou K, Prekates A, Themeli-Digalaki K, Tsakris A. 2011. Predictors of mortality in patients with bloodstream infections caused by KPCproducing Klebsiella pneumoniae and impact of appropriate antimicrobial treatment. Clin Microbiol Infect 17:1798-1803. http://dx.doi.org/10.1111/j.1469-0691.2011.03514.x.
39. Kauffmann F. 1949. On the serology of the Klebsiella group. Acta Pathol Microbiol Scand 26:381-406.
40. Matsumoto H, Tazaki T. 1970. Genetic recombination in Klebsiella pneumoniae. An approach to genetic linkage mapping. Jpn J Microbiol 14:129-141.
41. Matsumoto H, Tazaki T. 1971. Genetic mapping of aro, pyr, and pur markers in Klebsiella pneumoniae. Jpn J Microbiol 15:11-20. http://dx.doi.org/10.1111/j.1348-0421.1971.tb00546.x.
42. Clinical Laboratory Standards Institute. 2010. Performance standards for antimicrobial susceptibility testing; 20th informational supplement. Document M100-S20. Clinical Laboratory Standards Institute, Wayne, PA.