Dual role of photosensitizer and carrier material of fullerene in micelles for chemo-photodynamic therapy of cancer

Journal of Pharmaceutical Sciences

Volumn 103, Issue 10, 2014, Pages 3225-3234

  Guo, Xinhong ^a   Ding, Rui ^a   Zhang, Ying ^a   Ye, Ling ^a   Liu, Xin ^a   Chen, Caiping ^a   Zhang, Zhenzhong ^a   Zhang, Yun ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Antitumor effect; Cancer chemotherapy; Cellular mechanisms; Controlled release delivery; Diadduct malonic acid fullerene; Excipients; Micelles; Pharmacokinetics; Photosensitive

Indexed keywords

ANTINEOPLASTIC AGENT; DIADDUCT MALONIC ACID FULLERENE; DOCETAXEL; DRUG CARRIER; DUOPAFEI; FULLERENE DERIVATIVE; MALONIC ACID DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; MICELLE; PHOTOSENSITIZING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; AREA UNDER THE CURVE; ARTICLE; CANCER CHEMOTHERAPY; CELL CYCLE PARAMETERS; CELL ENCAPSULATION; COMPARATIVE EFFECTIVENESS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG STABILITY; EXPERIMENTAL NEOPLASM; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IRRADIATION; MEAN RESIDENCE TIME; MICELLE; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; SUSTAINED DRUG RELEASE; TISSUE DISTRIBUTION; WEIGHT REDUCTION; ANIMAL; CELL CYCLE; CHEMISTRY; NEOPLASMS; PATHOLOGY; PHOTOCHEMOTHERAPY; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; FULLERENES; MICE; MICELLES; MICROSCOPY, ELECTRON, TRANSMISSION; NEOPLASMS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS;

EID: 84923322425     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.24124     Document Type: Article

References (27)

1. Montellano A, Da Ros T, Bianco A, Prato M. 2011. Fullerene C (60) as a multifunctional system for drug and gene delivery. Nanoscale 3:4035-4041.
2. Shi J,Wang Z,Wang L,WangH, Li L, Yu X, Zhang J,MaR. 2013. Photodynamic therapy of a 2-methoxyestradiol tumor-targeting drug delivery system mediated by Asn-Gly-Arg in breast cancer. Int J Nanomed 8:1551-1562.
3. Shi J, Zhang H,Wang L, Li L,Wang H,Wang Z, Li Z, Chen C, Hou L, Zhang C, Zhang Z. 2013. PEI-derivatized fullerene drug delivery using folate as a homing device targeting to tumor. Biomaterials 34:251-261.
4. Liu J, Ohta SI, Sonod A, Yamada M, Yamamoto M, Nitta N, Murata K, Tabata Y. 2007. Preparation of PEG-conjugated fullerene containing Gd3+ ions for photodynamic therapy. J Control Release 117:104-110.
5. Pinteala M, Dascalu A, Ungurenasu C. 2009. Binding fullerenol C (60) (OH) (24) to dsDNA. Int J Nanomed 4:193-199.
6. Sitharaman B, Zakharian TY, Saraf A, Misra P, Ashcroft J, Pan S, Pham QP, Mikos AG, Wilson LJ, Engler DA. 2008. Water-soluble fullerene (C60) derivatives as nonviral gene-delivery vectors. Mol Pharm 5:567-578.
7. Hu Z, Zhang C, Huang Y, Sun S, Guan W, Yao Y. 2012. Photodynamic anticancercurr N activities of water-soluble C60 derivatives and their biological consequences in a HeLa cell line. Chem-Biol Interact 195:86-94.
8. Yamago S, Tokuyama H, Nakamura E, Kikuchi K, Kananishi S, Sueki K, Nakahara H, Enomoto S, Ambe F. 1995. In vivo biologicalbehavior of a water-misciblefullerene: 14 C labeling, absorption, distribution, excretion and acute toxicity. Chem Biol l2:385-389.
9. Kang B, Yu D, Dai Y, Chang S, Chen D, Ding Y. 2009. Cancer-cell targeting and photoacoustic therapy using carbon nanotubes as "bomb" agents. Small 5:1292-1301.
10. Yih TC, Al-Fandi M. 2006. Engineered nanoparticles as precise drug delivery systems. J Cell Biochem 97:1184-1190.
11. Subramani K, Haosseinkhani H, Khraisat A, Hosseinkhani M, Pathak Y. 2009. Targeting nanoparticles as drug delivery systems for cancer treatment. Curr Nanosci 5:135-140.
12. Ramakanth I, Patnaik A. 2008. Characteristics of solubilization and encapsulation of fullerence C60 in non-ionic Triton X-100 micelles. Carbon 46:692-698.
13. Yang X, Chen L, Qiao X, Fan C. 2007. Photo-induced damages of cytoplasmic and mitochondrialmembranes by a [C60] fullerene malonic acid derivative. Int J Toxicol 26:197-201.
14. Zuluaga MF, Lange N. 2008. Combination of photodynamic therapy with anti-cancer agents. Curr Med Chem 15:1655-1673.
15. Ayman K, Chen D, Patil Y, Ma L, Dou QP, Shekhar MP, Panyan J. 2010. Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance. J Control Release 141:137-144.
16. Pasquier E, Kavallaris M, Andre N. 2010. Metronomic chemotherapy: New rationale for new Directions. AActa Obstetricia et gynecologica Scandinavica 7:455-465.
17. Agostinis P, Berg K, Cengel KA, Foster TH, Girotti AW, Gollnick SO, Hahn SM, Hamblin MR, Juzeniene A, Kessel D, Korbelik M, Moan J, Mroz P, Nowis D, Piette J, Wilson BC, Golab J. 2011. Photodynamic therapy of cancer: An update. CA Cancer J Clin 61:250-281.
18. Clarke SJ, Rivory LP. 1999. Clinical pharmacokinetics of docetaxel. Clin Pharmacokinet 36: 99-114.
19. Chu CY, Yang CH, Yang CY, Hsiao GH, Chiu HC. 2000. Fixed erythrodysaesthesia plaque due to intravenous injection of docetaxel. Br J Dermatol 142:808-811.
20. Brown I, Shalli K, McDonald SL,Moir, SE, Hutcheon AW, Heys SD, Schofield AC. 2004. Reduced expression of p27 is a novel mechanism of docetaxel resistance in breast cancer cells. Breast Cancer Res 6:R601-R607.
21. Blanco E, Bey EA, Dong Y, Weinberg BD, Sutton DM, Boothman DA. 2007. B-lapachone-containing PEG-PLA polymermicelles as novel nanotherapeutics against NQO1-overexpressing tumor cells. J Control Release 122:365-374.
22. Zahra H, Mohsen A, Mahmoud GK, Seyed MR, Kambiz G. 2014.Synthesis and in vitro evaluation of a pH-sensitive PLA-PEG-folate based polymeric micelle for controlled delivery of docetaxel. Colloids Surf B Biointerfaces 116:309-317.
23. Wang Y, Yu L, Han L, Sha X, Fang X. 2007. Difunctional Pluronic copolymer micelles for paclitaxel delivery: Synergistic effect of folatemediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines. Int. J Pharm 337:63-73.
24. Shi J, Zhang H,Wang L, Li L,Wang H,Wang Z, Li Z, Chen C, Hou L, Zhang C, Zhang Z. 2013. PEI-derivatized fullerene drug delivery using folate as a homing device targeting to tumor. Biomaterials 34:251-261.
25. Ouahab A, Cheraga N, Onoja V, Shen Y, Tu JS, 2014. Novel pHsensitive charge-reversal cell penetrating peptide conjugated PEG-PLA micelles for docetaxel delivery: In vitro study. Int J Pharm 466:233-245.
26. Hans M, Shimoni K, Danino D, Siegel SJ, Lowman A. 2005. Synthesis and characterization of mPEG-PLA prodrugmicelles. Biomacromolecules 6:2708-2717.
27. Wang L, Liu Z, Liu D, Liu C, Juan Z, Zhang N. 2011. Docetaxel-loaded-lipid-based-nanosuspensions (DTX-LNS): Preparation, pharmacokinetics, tissue distribution and antitumor activity. Int J Pharm 413:194-201.