TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 7, 2015, Pages 2216-2221

  Ma, Guangyong ^a   Yasunaga, Jun Ichirou ^a   Akari, Hirofumi ^b   Matsuoka, Masao ^a   Green, Patrick L ^c  

^a KYOTO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

HTLV 1; LEF1; Tax; TCF1

Indexed keywords

I KAPPA B; LYMPHOID ENHANCER FACTOR 1; MESSENGER RNA; PROTEIN INHIBITOR; STAT5A PROTEIN; TAX PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR 7; VIRUS PROTEIN; LEF1 PROTEIN, HUMAN; TAX PROTEIN, HUMAN T-LYMPHOTROPHIC VIRUS 1; TCF7 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL FUNCTION; CELL PROLIFERATION; DNA BINDING; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; MACACA FUSCATA; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RETROVIRUS INFECTION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; VIRUS EXPRESSION; VIRUS LOAD; VIRUS REPLICATION; WNT SIGNALING PATHWAY; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; HUMAN T-LYMPHOTROPIC VIRUS 1; ISOLATION AND PURIFICATION; MACACA; PHYSIOLOGY; RETROVIRIDAE; TRANSCRIPTION INITIATION;

HUMAN T-LYMPHOTROPIC VIRUS 1; SIMIAN T-LYMPHOTROPIC VIRUS 1;

ANIMALS; CELL LINE; DOWN-REGULATION; GENE PRODUCTS, TAX; HUMAN T-LYMPHOTROPIC VIRUS 1; HUMANS; LYMPHOID ENHANCER-BINDING FACTOR 1; MACACA; SIMIAN T-LYMPHOTROPIC VIRUS 1; T CELL TRANSCRIPTION FACTOR 1; TRANSCRIPTIONAL ACTIVATION; VIRAL LOAD;

EID: 84923305010     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1419198112     Document Type: Article

References (45)

1. Gallo RC (2005) History of the discoveries of the first human retroviruses: HTLV-1 and HTLV-2. Oncogene 24(39):5926-5930.
2. Matsuoka M, Jeang KT (2007) Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer 7(4):270-280.
3. Grassmann R, Aboud M, Jeang KT (2005) Molecular mechanisms of cellular transformation by HTLV-1 Tax. Oncogene 24(39):5976-5985.
4. Tamiya S, et al. (1996) Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia. Blood 88(8):3065-3073.
5. Takeda S, et al. (2004) Genetic and epigenetic inactivation of tax gene in adult T-cell leukemia cells. Int J Cancer 109(4):559-567.
6. Furukawa Y, Kubota R, Tara M, Izumo S, Osame M (2001) Existence of escape mutant in HTLV-I tax during the development of adult T-cell leukemia. Blood 97(4):987-993.
7. Koiwa T, et al. (2002) 5'-long terminal repeat-selective CpG methylation of latent human T-cell leukemia virus type 1 provirus in vitro and in vivo. J Virol 76(18): 9389-9397.
8. Bangham CR (2009) CTL quality and the control of human retroviral infections. Eur J Immunol 39(7):1700-1712.
9. Satou Y, Yasunaga J, Yoshida M, Matsuoka M (2006) HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Proc Natl Acad Sci USA 103(3):720-725.
10. Staal FJ, Clevers HC (2005) WNT signalling and haematopoiesis: A WNT-WNT situation. Nat Rev Immunol 5(1):21-30.
11. Staal FJ, Luis TC, Tiemessen MM (2008) WNT signalling in the immune system: WNT is spreading its wings. Nat Rev Immunol 8(8):581-593.
12. OosterwegelM, et al. (1993) Differential expression of the HMG box factors TCF-1 and LEF-1 during murine embryogenesis. Development 118(2):439-448.
13. Verbeek S, et al. (1995) An HMG-box-containing T-cell factor required for thymocyte differentiation. Nature 374(6517):70-74.
14. Okamura RM, et al. (1998) Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1. Immunity 8(1):11-20.
15. Willinger T, et al. (2006) Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. J Immunol 176(3):1439-1446.
16. Ma G, Yasunaga J, Fan J, Yanagawa S, Matsuoka M (2013) HTLV-1 bZIP factor dysregulates the Wnt pathways to support proliferation and migration of adult T-cell leukemia cells. Oncogene 32(36):4222-4230.
17. Narasipura SD, et al. (2012) Role of β-catenin and TCF/LEF family members in transcriptional activity of HIV in astrocytes. J Virol 86(4):1911-1921.
18. Mitchell MS, et al. (2007) Phenotypic and genotypic comparisons of human T-cell leukemia virus type 1 reverse transcriptases from infected T-cell lines and patient samples. J Virol 81(9):4422-4428.
19. Yoshida M, Satou Y, Yasunaga J, Fujisawa J, Matsuoka M (2008) Transcriptional control of spliced and unspliced human T-cell leukemia virus type 1 bZIP factor (HBZ) gene. J Virol 82(19):9359-9368.
20. Azimi N, et al. (1998) Human T cell lymphotropic virus type I Tax protein trans-activates interleukin 15 gene transcription through an NF-kappaB site. Proc Natl Acad Sci USA 95(5):2452-2457.
21. Macian F (2005) NFAT proteins: Key regulators of T-cell development and function. Nat Rev Immunol 5(6):472-484.
22. Welte T, et al. (1999) STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation. Science 283(5399):222-225.
23. Migone TS, et al. (1995) Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science 269(5220):79-81.
24. Lin JX, Leonard WJ (2000) The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene 19(21):2566-2576.
25. Nakamura N, et al. (1999) Human T-cell leukemia virus type 1 Tax protein induces the expression of STAT1 and STAT5 genes in T-cells. Oncogene 18(17):2667-2675.
26. Miura M, et al. (2013) Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection. Retrovirology 10:118.
27. Kannian P, et al. (2012) Distinct transformation tropism exhibited by human T lymphotropic virus type 1 (HTLV-1) and HTLV-2 is the result of postinfection T cell clonal expansion. J Virol 86(7):3757-3766.
28. Yasunaga Ji, et al. (2001) Impaired production of naive T lymphocytes in human T-cell leukemia virus type I-infected individuals: Its implications in the immunodeficient state. Blood 97(10):3177-3183.
29. Wolf D, Goff SP (2008) Host restriction factors blocking retroviral replication. Annu Rev Genet 42:143-163.
30. Bieniasz PD (2004) Intrinsic immunity: A front-line defense against viral attack. Nat Immunol 5(11):1109-1115.
31. Blanco-Melo D, Venkatesh S, Bieniasz PD (2012) Intrinsic cellular defenses against human immunodeficiency viruses. Immunity 37(3):399-411.
32. Derse D, Hill SA, Princler G, Lloyd P, Heidecker G (2007) Resistance of human T cell leukemia virus type 1 to APOBEC3G restriction is mediated by elements in nucleocapsid. Proc Natl Acad Sci USA 104(8):2915-2920.
33. Sze A, et al. (2013) Host restriction factor SAMHD1 limits human T cell leukemia virus type 1 infection of monocytes via STING-mediated apoptosis. Cell Host Microbe 14(4): 422-434.
34. Manel N, Battini JL, Taylor N, Sitbon M (2005) HTLV-1 tropism and envelope receptor. Oncogene 24(39):6016-6025.
35. Bertotto A, et al. (1990) Human breast milk T lymphocytes display the phenotype and functional characteristics of memory T cells. Eur J Immunol 20(8):1877-1880.
36. Hasegawa H, et al. (2006) Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I. Nat Med 12(4):466-472.
37. Weber BN, et al. (2011) A critical role for TCF-1 in T-lineage specification and differentiation. Nature 476(7358):63-68.
38. Xue HH, Zhao DM (2012) Regulation of mature T cell responses by the Wnt signaling pathway. Ann N Y Acad Sci 1247:16-33.
39. Merl S, et al. (1984) Efficient transformation of previously activated and dividing T lymphocytes by human T cell leukemia-lymphoma virus. Blood 64(5):967-974.
40. Villaudy J, et al. (2011) HTLV-1 propels thymic human T cell development in "human immune system" Rag2-/-gamma c-/-mice. PLoS Pathog 7(9):e1002231.
41. Belrose G, et al. (2011) Effects of valproate on Tax and HBZ expression in HTLV-1 and HAM/TSP T lymphocytes. Blood 118(9):2483-2491.
42. Zhi H, et al. (2011) NF-κB hyper-activation by HTLV-1 tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ. PLoS Pathog 7(4):e1002025.
43. Zhao T, et al. (2009) Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-kappaB. Blood 113(12):2755-2764.
44. Matsuoka M, Yasunaga J (2013) Human T-cell leukemia virus type 1: Replication, proliferation and propagation by Tax and HTLV-1 bZIP factor. Curr Opin Virol 3(6): 684-691.
45. Peloponese JM, Jr, Yasunaga J, Kinjo T, Watashi K, Jeang KT (2009) Peptidylproline cis-trans-isomerase Pin1 interacts with human T-cell leukemia virus type 1 tax and modulates its activation of NF-kappaB. J Virol 83(7):3238-3248.